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Protein

Fibronectin type 3 and ankyrin repeat domains 1 protein

Gene

Fank1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type 3 and ankyrin repeat domains 1 protein
Alternative name(s):
Germ cell-specific gene 1 protein
Short name:
GSG1
Gene namesi
Name:Fank1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914180. Fank1.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Weakly detected in the cytoplasm of elongated spermatids.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Fibronectin type 3 and ankyrin repeat domains 1 proteinPRO_0000066991Add
BLAST

Proteomic databases

MaxQBiQ9DAM9.
PaxDbiQ9DAM9.
PRIDEiQ9DAM9.

PTM databases

PhosphoSiteiQ9DAM9.

Expressioni

Tissue specificityi

Mostly restricted to testis (at protein level), including mid to late pachytene spermatocytes (stages VI-X), diplotene spermatocytes (stage XI), meiotically dividing spermatocytes (stage XII) and spermatids in steps 1-14. Highest levels in late pachytene spermatocytes and spermatids in steps 1-9.1 Publication

Developmental stagei

In the developing testis, first detected at postnatal day 14 (P14) and levels increase after P20 (at protein level). At P20, detected in pachytene spermatocytes and round spermatids, but not in preleptotene and leptotene spermatocytes. Not detected in testis at P10. Detected in germinal vesicle (GV) stage oocytes and in embryos up to the 2-cell stage, but not in morula or blastocysts.2 Publications

Gene expression databases

BgeeiQ9DAM9.
CleanExiMM_FANK1.
ExpressionAtlasiQ9DAM9. baseline and differential.
GenevisibleiQ9DAM9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069013.

Structurei

Secondary structure

1
344
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 285Combined sources
Helixi41 – 433Combined sources
Beta strandi46 – 527Combined sources
Turni54 – 563Combined sources
Beta strandi59 – 668Combined sources
Beta strandi68 – 747Combined sources
Beta strandi80 – 889Combined sources
Beta strandi90 – 923Combined sources
Beta strandi94 – 963Combined sources
Beta strandi100 – 1034Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WFUNMR-A1-107[»]
ProteinModelPortaliQ9DAM9.
SMRiQ9DAM9. Positions 1-107, 114-335.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DAM9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 10898Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST
Repeati109 – 13931ANK 1Add
BLAST
Repeati143 – 17230ANK 2Add
BLAST
Repeati176 – 20530ANK 3Add
BLAST
Repeati209 – 23830ANK 4Add
BLAST
Repeati243 – 27331ANK 5Add
BLAST
Repeati277 – 30630ANK 6Add
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129724.
HOGENOMiHOG000293255.
HOVERGENiHBG051552.
InParanoidiQ9DAM9.
OMAiCNVIEWM.
OrthoDBiEOG7X3QR6.
PhylomeDBiQ9DAM9.
TreeFamiTF106234.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
SM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPHKVVPLS KPHPPVVGKV THHSIELYWD LEQKEKRQGP QEQWLRFSIE
60 70 80 90 100
EEDPKMHSYG VIYTGYATRH VVEGLEPRTL YKFRLKVTSP SGEYEYSPVV
110 120 130 140 150
SVATTREPIS SEHFHRAVSV NDEDLLLRIL EGGHVMIDVP NKFGFTALMV
160 170 180 190 200
AAQKGYTRLV KILVSNGTDV NLKNGSGKDS LMLACYAGHL DVVKYLRRHG
210 220 230 240 250
ASWEARDLGG CTALHWAADG GHCSVIDWMI KDGCEVDVVD TGSGWTPLMR
260 270 280 290 300
VSAVTGSQKV ASLLIEAGAD VNIKDKDGKT PLMVAVLNNH EQLVQLLLDK
310 320 330 340
GADATVKNEF GKGVLEMARV FDRQNVLSLL EEKKKKMPRK SSVH
Length:344
Mass (Da):38,260
Last modified:June 1, 2001 - v1
Checksum:i88FB61A183283AB4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621I → T in BAB30580 (PubMed:16141072).Curated
Sequence conflicti207 – 2071D → A in BAB30580 (PubMed:16141072).Curated
Sequence conflicti261 – 2611A → P in BAB30580 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY819025 mRNA. Translation: AAV68048.1.
AK005694 mRNA. Translation: BAB24192.1.
AK017071 mRNA. Translation: BAB30580.1.
BC046278 mRNA. Translation: AAH46278.1.
CCDSiCCDS21937.1.
RefSeqiNP_080126.1. NM_025850.2.
UniGeneiMm.87448.

Genome annotation databases

EnsembliENSMUST00000065359; ENSMUSP00000069013; ENSMUSG00000053111.
GeneIDi66930.
KEGGimmu:66930.
UCSCiuc009kdn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY819025 mRNA. Translation: AAV68048.1.
AK005694 mRNA. Translation: BAB24192.1.
AK017071 mRNA. Translation: BAB30580.1.
BC046278 mRNA. Translation: AAH46278.1.
CCDSiCCDS21937.1.
RefSeqiNP_080126.1. NM_025850.2.
UniGeneiMm.87448.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WFUNMR-A1-107[»]
ProteinModelPortaliQ9DAM9.
SMRiQ9DAM9. Positions 1-107, 114-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069013.

PTM databases

PhosphoSiteiQ9DAM9.

Proteomic databases

MaxQBiQ9DAM9.
PaxDbiQ9DAM9.
PRIDEiQ9DAM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065359; ENSMUSP00000069013; ENSMUSG00000053111.
GeneIDi66930.
KEGGimmu:66930.
UCSCiuc009kdn.1. mouse.

Organism-specific databases

CTDi92565.
MGIiMGI:1914180. Fank1.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129724.
HOGENOMiHOG000293255.
HOVERGENiHBG051552.
InParanoidiQ9DAM9.
OMAiCNVIEWM.
OrthoDBiEOG7X3QR6.
PhylomeDBiQ9DAM9.
TreeFamiTF106234.

Miscellaneous databases

EvolutionaryTraceiQ9DAM9.
NextBioi323049.
PROiQ9DAM9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DAM9.
CleanExiMM_FANK1.
ExpressionAtlasiQ9DAM9. baseline and differential.
GenevisibleiQ9DAM9. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
SM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Specific maternal transcripts in bovine oocytes and cleavaged embryos: identification with novel DDRT-PCR methods."
    Hwang K.-C., Park S.-Y., Park S.-P., Lim J.H., Cui X.-S., Kim N.-H.
    Mol. Reprod. Dev. 71:275-283(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: ICR.
    Tissue: Ovary.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.
  5. "Solution structure of fibronectin type-III domain of mouse hypothetical protein BAB30580."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-107.
  6. "Fank1 is a testis-specific gene encoding a nuclear protein exclusively expressed during the transition from the meiotic to the haploid phase of spermatogenesis."
    Zheng Z., Zheng H., Yan W.
    Gene Expr. Patterns 7:777-783(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiFANK1_MOUSE
AccessioniPrimary (citable) accession number: Q9DAM9
Secondary accession number(s): Q9CUA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.