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Q9DAM5

- TPC_MOUSE

UniProt

Q9DAM5 - TPC_MOUSE

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Protein

Mitochondrial thiamine pyrophosphate carrier

Gene

Slc25a19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier
Alternative name(s):
Solute carrier family 25 member 19
Gene namesi
Name:Slc25a19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1914533. Slc25a19.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. mitochondrion Source: MGI
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Mitochondrial thiamine pyrophosphate carrierPRO_0000090613Add
BLAST

Proteomic databases

MaxQBiQ9DAM5.
PaxDbiQ9DAM5.
PRIDEiQ9DAM5.

PTM databases

PhosphoSiteiQ9DAM5.

Expressioni

Gene expression databases

BgeeiQ9DAM5.
ExpressionAtlasiQ9DAM5. baseline and differential.
GenevestigatoriQ9DAM5.

Structurei

3D structure databases

ProteinModelPortaliQ9DAM5.
SMRiQ9DAM5. Positions 20-305.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei87 – 10721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei173 – 19321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei220 – 24021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei293 – 31321Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 10694Solcar 1Add
BLAST
Repeati116 – 20287Solcar 2Add
BLAST
Repeati214 – 30996Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi241 – 2466Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310116.
GeneTreeiENSGT00550000074902.
HOGENOMiHOG000165726.
HOVERGENiHBG105731.
InParanoidiQ9DAM5.
KOiK15108.
OMAiMFFWYEF.
OrthoDBiEOG74BJSC.
PhylomeDBiQ9DAM5.
TreeFamiTF313047.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAM5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGYDAKADV RSNSKLEVAV AGSVSGFVTR ALISPLDVIK IRFQLQIERL
60 70 80 90 100
CPSDPNAKYH GIFQAAKQIL QEEGPRAFWK GHVPAQILSI GYGAVQFLAF
110 120 130 140 150
EELTELLYQA NLYQTHQFSA HFVCGGLSAG TATLTVHPVD VLRTRLAAQG
160 170 180 190 200
EPKIYNNLRE AIRTMYKTEG PFVFYKGLTP TVIAIFPYAG LQFSCYRSLK
210 220 230 240 250
RAYDWLIPPD GKQTGNLKNL LCGCGSGVIS KTFTYPLDLI KKRLQVGGFE
260 270 280 290 300
HARSAFGQVR SYRGLLDLTQ QVLQEEGTRG FFKGLSPSLM KAALSTGFMF
310
FWYELFCNLF HCIRREDR
Length:318
Mass (Da):35,618
Last modified:June 1, 2001 - v1
Checksum:i006DC5B11FA12A5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005710 mRNA. Translation: BAB24199.1.
AK172622 mRNA. Translation: BAE43100.1.
AL645470 Genomic DNA. Translation: CAM22998.1.
BC018167 mRNA. Translation: AAH18167.1.
CCDSiCCDS25644.1.
RefSeqiNP_001239313.1. NM_001252384.1.
NP_001239324.1. NM_001252395.1.
NP_080347.1. NM_026071.3.
XP_006534042.1. XM_006533979.1.
UniGeneiMm.383426.
Mm.489774.

Genome annotation databases

EnsembliENSMUST00000021089; ENSMUSP00000021089; ENSMUSG00000020744.
ENSMUST00000178003; ENSMUSP00000137534; ENSMUSG00000020744.
GeneIDi67283.
KEGGimmu:67283.
UCSCiuc007mig.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005710 mRNA. Translation: BAB24199.1 .
AK172622 mRNA. Translation: BAE43100.1 .
AL645470 Genomic DNA. Translation: CAM22998.1 .
BC018167 mRNA. Translation: AAH18167.1 .
CCDSi CCDS25644.1.
RefSeqi NP_001239313.1. NM_001252384.1.
NP_001239324.1. NM_001252395.1.
NP_080347.1. NM_026071.3.
XP_006534042.1. XM_006533979.1.
UniGenei Mm.383426.
Mm.489774.

3D structure databases

ProteinModelPortali Q9DAM5.
SMRi Q9DAM5. Positions 20-305.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9DAM5.

Proteomic databases

MaxQBi Q9DAM5.
PaxDbi Q9DAM5.
PRIDEi Q9DAM5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021089 ; ENSMUSP00000021089 ; ENSMUSG00000020744 .
ENSMUST00000178003 ; ENSMUSP00000137534 ; ENSMUSG00000020744 .
GeneIDi 67283.
KEGGi mmu:67283.
UCSCi uc007mig.2. mouse.

Organism-specific databases

CTDi 60386.
MGIi MGI:1914533. Slc25a19.

Phylogenomic databases

eggNOGi NOG310116.
GeneTreei ENSGT00550000074902.
HOGENOMi HOG000165726.
HOVERGENi HBG105731.
InParanoidi Q9DAM5.
KOi K15108.
OMAi MFFWYEF.
OrthoDBi EOG74BJSC.
PhylomeDBi Q9DAM5.
TreeFami TF313047.

Miscellaneous databases

NextBioi 324108.
PROi Q9DAM5.
SOURCEi Search...

Gene expression databases

Bgeei Q9DAM5.
ExpressionAtlasi Q9DAM5. baseline and differential.
Genevestigatori Q9DAM5.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Spleen and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTPC_MOUSE
AccessioniPrimary (citable) accession number: Q9DAM5
Secondary accession number(s): A2A9V6, Q3T9C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3