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Q9DAM5

- TPC_MOUSE

UniProt

Q9DAM5 - TPC_MOUSE

Protein

Mitochondrial thiamine pyrophosphate carrier

Gene

Slc25a19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial thiamine pyrophosphate carrier
    Alternative name(s):
    Solute carrier family 25 member 19
    Gene namesi
    Name:Slc25a19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1914533. Slc25a19.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Mitochondrial thiamine pyrophosphate carrierPRO_0000090613Add
    BLAST

    Proteomic databases

    PaxDbiQ9DAM5.
    PRIDEiQ9DAM5.

    PTM databases

    PhosphoSiteiQ9DAM5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9DAM5.
    BgeeiQ9DAM5.
    GenevestigatoriQ9DAM5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DAM5.
    SMRiQ9DAM5. Positions 20-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 24021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati13 – 10694Solcar 1Add
    BLAST
    Repeati116 – 20287Solcar 2Add
    BLAST
    Repeati214 – 30996Solcar 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi241 – 2466Substrate recognitionBy similarity

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG310116.
    GeneTreeiENSGT00550000074902.
    HOGENOMiHOG000165726.
    HOVERGENiHBG105731.
    InParanoidiA2A9V6.
    KOiK15108.
    OMAiMFFWYEF.
    OrthoDBiEOG74BJSC.
    PhylomeDBiQ9DAM5.
    TreeFamiTF313047.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DAM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGYDAKADV RSNSKLEVAV AGSVSGFVTR ALISPLDVIK IRFQLQIERL    50
    CPSDPNAKYH GIFQAAKQIL QEEGPRAFWK GHVPAQILSI GYGAVQFLAF 100
    EELTELLYQA NLYQTHQFSA HFVCGGLSAG TATLTVHPVD VLRTRLAAQG 150
    EPKIYNNLRE AIRTMYKTEG PFVFYKGLTP TVIAIFPYAG LQFSCYRSLK 200
    RAYDWLIPPD GKQTGNLKNL LCGCGSGVIS KTFTYPLDLI KKRLQVGGFE 250
    HARSAFGQVR SYRGLLDLTQ QVLQEEGTRG FFKGLSPSLM KAALSTGFMF 300
    FWYELFCNLF HCIRREDR 318
    Length:318
    Mass (Da):35,618
    Last modified:June 1, 2001 - v1
    Checksum:i006DC5B11FA12A5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005710 mRNA. Translation: BAB24199.1.
    AK172622 mRNA. Translation: BAE43100.1.
    AL645470 Genomic DNA. Translation: CAM22998.1.
    BC018167 mRNA. Translation: AAH18167.1.
    CCDSiCCDS25644.1.
    RefSeqiNP_001239313.1. NM_001252384.1.
    NP_001239324.1. NM_001252395.1.
    NP_080347.1. NM_026071.3.
    XP_006534042.1. XM_006533979.1.
    UniGeneiMm.383426.
    Mm.489774.

    Genome annotation databases

    EnsembliENSMUST00000021089; ENSMUSP00000021089; ENSMUSG00000020744.
    ENSMUST00000178003; ENSMUSP00000137534; ENSMUSG00000020744.
    GeneIDi67283.
    KEGGimmu:67283.
    UCSCiuc007mig.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005710 mRNA. Translation: BAB24199.1 .
    AK172622 mRNA. Translation: BAE43100.1 .
    AL645470 Genomic DNA. Translation: CAM22998.1 .
    BC018167 mRNA. Translation: AAH18167.1 .
    CCDSi CCDS25644.1.
    RefSeqi NP_001239313.1. NM_001252384.1.
    NP_001239324.1. NM_001252395.1.
    NP_080347.1. NM_026071.3.
    XP_006534042.1. XM_006533979.1.
    UniGenei Mm.383426.
    Mm.489774.

    3D structure databases

    ProteinModelPortali Q9DAM5.
    SMRi Q9DAM5. Positions 20-310.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9DAM5.

    Proteomic databases

    PaxDbi Q9DAM5.
    PRIDEi Q9DAM5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021089 ; ENSMUSP00000021089 ; ENSMUSG00000020744 .
    ENSMUST00000178003 ; ENSMUSP00000137534 ; ENSMUSG00000020744 .
    GeneIDi 67283.
    KEGGi mmu:67283.
    UCSCi uc007mig.2. mouse.

    Organism-specific databases

    CTDi 60386.
    MGIi MGI:1914533. Slc25a19.

    Phylogenomic databases

    eggNOGi NOG310116.
    GeneTreei ENSGT00550000074902.
    HOGENOMi HOG000165726.
    HOVERGENi HBG105731.
    InParanoidi A2A9V6.
    KOi K15108.
    OMAi MFFWYEF.
    OrthoDBi EOG74BJSC.
    PhylomeDBi Q9DAM5.
    TreeFami TF313047.

    Miscellaneous databases

    NextBioi 324108.
    PROi Q9DAM5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DAM5.
    Bgeei Q9DAM5.
    Genevestigatori Q9DAM5.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Spleen and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTPC_MOUSE
    AccessioniPrimary (citable) accession number: Q9DAM5
    Secondary accession number(s): A2A9V6, Q3T9C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3