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Protein

Mitochondrial thiamine pyrophosphate carrier

Gene

Slc25a19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-196819. Vitamin B1 (thiamin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier
Alternative name(s):
Solute carrier family 25 member 19
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914533. Slc25a19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei122 – 142Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei173 – 193Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906131 – 318Mitochondrial thiamine pyrophosphate carrierAdd BLAST318

Proteomic databases

MaxQBiQ9DAM5.
PaxDbiQ9DAM5.
PRIDEiQ9DAM5.

PTM databases

PhosphoSitePlusiQ9DAM5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020744.
ExpressionAtlasiQ9DAM5. baseline and differential.
GenevisibleiQ9DAM5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021089.

Structurei

3D structure databases

ProteinModelPortaliQ9DAM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 106Solcar 1Add BLAST94
Repeati116 – 202Solcar 2Add BLAST87
Repeati214 – 309Solcar 3Add BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi241 – 246Substrate recognitionBy similarity6

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00550000074902.
HOGENOMiHOG000165726.
HOVERGENiHBG105731.
InParanoidiQ9DAM5.
KOiK15108.
OMAiPISHTIC.
OrthoDBiEOG091G0FNV.
PhylomeDBiQ9DAM5.
TreeFamiTF313047.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGYDAKADV RSNSKLEVAV AGSVSGFVTR ALISPLDVIK IRFQLQIERL
60 70 80 90 100
CPSDPNAKYH GIFQAAKQIL QEEGPRAFWK GHVPAQILSI GYGAVQFLAF
110 120 130 140 150
EELTELLYQA NLYQTHQFSA HFVCGGLSAG TATLTVHPVD VLRTRLAAQG
160 170 180 190 200
EPKIYNNLRE AIRTMYKTEG PFVFYKGLTP TVIAIFPYAG LQFSCYRSLK
210 220 230 240 250
RAYDWLIPPD GKQTGNLKNL LCGCGSGVIS KTFTYPLDLI KKRLQVGGFE
260 270 280 290 300
HARSAFGQVR SYRGLLDLTQ QVLQEEGTRG FFKGLSPSLM KAALSTGFMF
310
FWYELFCNLF HCIRREDR
Length:318
Mass (Da):35,618
Last modified:June 1, 2001 - v1
Checksum:i006DC5B11FA12A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005710 mRNA. Translation: BAB24199.1.
AK172622 mRNA. Translation: BAE43100.1.
AL645470 Genomic DNA. Translation: CAM22998.1.
BC018167 mRNA. Translation: AAH18167.1.
CCDSiCCDS25644.1.
RefSeqiNP_001239313.1. NM_001252384.1.
NP_001239324.1. NM_001252395.1.
NP_080347.1. NM_026071.3.
XP_006534042.1. XM_006533979.3.
XP_017170203.1. XM_017314714.1.
UniGeneiMm.383426.
Mm.489774.

Genome annotation databases

EnsembliENSMUST00000021089; ENSMUSP00000021089; ENSMUSG00000020744.
ENSMUST00000178003; ENSMUSP00000137534; ENSMUSG00000020744.
GeneIDi67283.
KEGGimmu:67283.
UCSCiuc007mig.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005710 mRNA. Translation: BAB24199.1.
AK172622 mRNA. Translation: BAE43100.1.
AL645470 Genomic DNA. Translation: CAM22998.1.
BC018167 mRNA. Translation: AAH18167.1.
CCDSiCCDS25644.1.
RefSeqiNP_001239313.1. NM_001252384.1.
NP_001239324.1. NM_001252395.1.
NP_080347.1. NM_026071.3.
XP_006534042.1. XM_006533979.3.
XP_017170203.1. XM_017314714.1.
UniGeneiMm.383426.
Mm.489774.

3D structure databases

ProteinModelPortaliQ9DAM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021089.

PTM databases

PhosphoSitePlusiQ9DAM5.

Proteomic databases

MaxQBiQ9DAM5.
PaxDbiQ9DAM5.
PRIDEiQ9DAM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021089; ENSMUSP00000021089; ENSMUSG00000020744.
ENSMUST00000178003; ENSMUSP00000137534; ENSMUSG00000020744.
GeneIDi67283.
KEGGimmu:67283.
UCSCiuc007mig.2. mouse.

Organism-specific databases

CTDi60386.
MGIiMGI:1914533. Slc25a19.

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00550000074902.
HOGENOMiHOG000165726.
HOVERGENiHBG105731.
InParanoidiQ9DAM5.
KOiK15108.
OMAiPISHTIC.
OrthoDBiEOG091G0FNV.
PhylomeDBiQ9DAM5.
TreeFamiTF313047.

Enzyme and pathway databases

ReactomeiR-MMU-196819. Vitamin B1 (thiamin) metabolism.

Miscellaneous databases

PROiQ9DAM5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020744.
ExpressionAtlasiQ9DAM5. baseline and differential.
GenevisibleiQ9DAM5. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPC_MOUSE
AccessioniPrimary (citable) accession number: Q9DAM5
Secondary accession number(s): A2A9V6, Q3T9C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.