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Protein

Mitochondrial thiamine pyrophosphate carrier

Gene

Slc25a19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-196819 Vitamin B1 (thiamin) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier
Alternative name(s):
Solute carrier family 25 member 19
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914533 Slc25a19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei122 – 142Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei173 – 193Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906131 – 318Mitochondrial thiamine pyrophosphate carrierAdd BLAST318

Proteomic databases

MaxQBiQ9DAM5
PaxDbiQ9DAM5
PRIDEiQ9DAM5

PTM databases

PhosphoSitePlusiQ9DAM5

Expressioni

Gene expression databases

BgeeiENSMUSG00000020744
ExpressionAtlasiQ9DAM5 baseline and differential
GenevisibleiQ9DAM5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021089

Structurei

3D structure databases

ProteinModelPortaliQ9DAM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 106Solcar 1Add BLAST94
Repeati116 – 202Solcar 2Add BLAST87
Repeati214 – 309Solcar 3Add BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi241 – 246Substrate recognitionBy similarity6

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752 Eukaryota
ENOG410ZRF1 LUCA
GeneTreeiENSGT00550000074902
HOGENOMiHOG000165726
HOVERGENiHBG105731
InParanoidiQ9DAM5
KOiK15108
OMAiWKGNVPA
OrthoDBiEOG091G0FNV
PhylomeDBiQ9DAM5
TreeFamiTF313047

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q9DAM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGYDAKADV RSNSKLEVAV AGSVSGFVTR ALISPLDVIK IRFQLQIERL
60 70 80 90 100
CPSDPNAKYH GIFQAAKQIL QEEGPRAFWK GHVPAQILSI GYGAVQFLAF
110 120 130 140 150
EELTELLYQA NLYQTHQFSA HFVCGGLSAG TATLTVHPVD VLRTRLAAQG
160 170 180 190 200
EPKIYNNLRE AIRTMYKTEG PFVFYKGLTP TVIAIFPYAG LQFSCYRSLK
210 220 230 240 250
RAYDWLIPPD GKQTGNLKNL LCGCGSGVIS KTFTYPLDLI KKRLQVGGFE
260 270 280 290 300
HARSAFGQVR SYRGLLDLTQ QVLQEEGTRG FFKGLSPSLM KAALSTGFMF
310
FWYELFCNLF HCIRREDR
Length:318
Mass (Da):35,618
Last modified:June 1, 2001 - v1
Checksum:i006DC5B11FA12A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005710 mRNA Translation: BAB24199.1
AK172622 mRNA Translation: BAE43100.1
AL645470 Genomic DNA No translation available.
BC018167 mRNA Translation: AAH18167.1
CCDSiCCDS25644.1
RefSeqiNP_001239313.1, NM_001252384.1
NP_001239324.1, NM_001252395.1
NP_080347.1, NM_026071.3
XP_006534042.1, XM_006533979.3
XP_017170203.1, XM_017314714.1
UniGeneiMm.383426
Mm.489774

Genome annotation databases

EnsembliENSMUST00000021089; ENSMUSP00000021089; ENSMUSG00000020744
ENSMUST00000178003; ENSMUSP00000137534; ENSMUSG00000020744
GeneIDi67283
KEGGimmu:67283
UCSCiuc007mig.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTPC_MOUSE
AccessioniPrimary (citable) accession number: Q9DAM5
Secondary accession number(s): A2A9V6, Q3T9C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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