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Q9DAM5 (TPC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial thiamine pyrophosphate carrier
Alternative name(s):
Solute carrier family 25 member 19
Gene names
Name:Slc25a19
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Mitochondrial thiamine pyrophosphate carrier
PRO_0000090613

Regions

Transmembrane19 – 3921Helical; Name=1; Potential
Transmembrane87 – 10721Helical; Name=2; Potential
Transmembrane122 – 14221Helical; Name=3; Potential
Transmembrane173 – 19321Helical; Name=4; Potential
Transmembrane220 – 24021Helical; Name=5; Potential
Transmembrane293 – 31321Helical; Name=6; Potential
Repeat13 – 10694Solcar 1
Repeat116 – 20287Solcar 2
Repeat214 – 30996Solcar 3
Motif241 – 2466Substrate recognition By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9DAM5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 006DC5B11FA12A5B

FASTA31835,618
        10         20         30         40         50         60 
MVGYDAKADV RSNSKLEVAV AGSVSGFVTR ALISPLDVIK IRFQLQIERL CPSDPNAKYH 

        70         80         90        100        110        120 
GIFQAAKQIL QEEGPRAFWK GHVPAQILSI GYGAVQFLAF EELTELLYQA NLYQTHQFSA 

       130        140        150        160        170        180 
HFVCGGLSAG TATLTVHPVD VLRTRLAAQG EPKIYNNLRE AIRTMYKTEG PFVFYKGLTP 

       190        200        210        220        230        240 
TVIAIFPYAG LQFSCYRSLK RAYDWLIPPD GKQTGNLKNL LCGCGSGVIS KTFTYPLDLI 

       250        260        270        280        290        300 
KKRLQVGGFE HARSAFGQVR SYRGLLDLTQ QVLQEEGTRG FFKGLSPSLM KAALSTGFMF 

       310 
FWYELFCNLF HCIRREDR 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Spleen and Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK005710 mRNA. Translation: BAB24199.1.
AK172622 mRNA. Translation: BAE43100.1.
AL645470 Genomic DNA. Translation: CAM22998.1.
BC018167 mRNA. Translation: AAH18167.1.
RefSeqNP_001239313.1. NM_001252384.1.
NP_001239324.1. NM_001252395.1.
NP_080347.1. NM_026071.3.
XP_006534042.1. XM_006533979.1.
UniGeneMm.383426.
Mm.489774.

3D structure databases

ProteinModelPortalQ9DAM5.
SMRQ9DAM5. Positions 20-305.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9DAM5.

Proteomic databases

PaxDbQ9DAM5.
PRIDEQ9DAM5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021089; ENSMUSP00000021089; ENSMUSG00000020744.
ENSMUST00000178003; ENSMUSP00000137534; ENSMUSG00000020744.
GeneID67283.
KEGGmmu:67283.
UCSCuc007mig.2. mouse.

Organism-specific databases

CTD60386.
MGIMGI:1914533. Slc25a19.

Phylogenomic databases

eggNOGNOG310116.
GeneTreeENSGT00550000074902.
HOGENOMHOG000165726.
HOVERGENHBG105731.
InParanoidA2A9V6.
KOK15108.
OMAKGLMDCA.
OrthoDBEOG74BJSC.
PhylomeDBQ9DAM5.
TreeFamTF313047.

Gene expression databases

ArrayExpressQ9DAM5.
BgeeQ9DAM5.
GenevestigatorQ9DAM5.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio324108.
PROQ9DAM5.
SOURCESearch...

Entry information

Entry nameTPC_MOUSE
AccessionPrimary (citable) accession number: Q9DAM5
Secondary accession number(s): A2A9V6, Q3T9C4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot