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Protein

14 kDa phosphohistidine phosphatase

Gene

Phpt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits phosphohistidine phosphatase activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201SubstrateBy similarity
Active sitei52 – 521Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
14 kDa phosphohistidine phosphatase (EC:3.1.3.-)
Alternative name(s):
Phosphohistidine phosphatase 1
Gene namesi
Name:Phpt1
Synonyms:Php14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1922704. Phpt1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • extracellular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12412414 kDa phosphohistidine phosphatasePRO_0000206153Add
BLAST

Proteomic databases

EPDiQ9DAK9.
MaxQBiQ9DAK9.
PaxDbiQ9DAK9.
PRIDEiQ9DAK9.

2D gel databases

REPRODUCTION-2DPAGEIPI00118757.
Q9DAK9.

PTM databases

iPTMnetiQ9DAK9.
PhosphoSiteiQ9DAK9.

Expressioni

Gene expression databases

BgeeiQ9DAK9.
CleanExiMM_PHPT1.
GenevisibleiQ9DAK9. MM.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1855555.
STRINGi10090.ENSMUSP00000037417.

Structurei

3D structure databases

ProteinModelPortaliQ9DAK9.
SMRiQ9DAK9. Positions 3-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 953Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the janus family.Curated

Phylogenomic databases

eggNOGiENOG410IZ5G. Eukaryota.
ENOG4111SA6. LUCA.
GeneTreeiENSGT00390000002738.
HOGENOMiHOG000231559.
HOVERGENiHBG053589.
InParanoidiQ9DAK9.
KOiK01112.
OMAiGWAEYHA.
OrthoDBiEOG7S2215.
PhylomeDBiQ9DAK9.
TreeFamiTF315158.

Family and domain databases

InterProiIPR007702. Janus.
IPR028441. PHPT1.
[Graphical view]
PANTHERiPTHR12258:SF10. PTHR12258:SF10. 1 hit.
PfamiPF05005. Ocnus. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADLGQIPD VDIDSDGVFK YVLIRVHLAE PSGDPAKECK EIVRGYKWAE
60 70 80 90 100
YHADIYDKVS GELQRNGYDC ECLGGGRISH QSQDRKIHVY GYSMGYGRAQ
110 120
HSVSTEKIKA KYPDYEVTWA DDGY
Length:124
Mass (Da):13,997
Last modified:June 1, 2001 - v1
Checksum:i583F9A3CE95A2F66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005756 mRNA. Translation: BAB24222.1.
BC028657 mRNA. Translation: AAH28657.1.
CCDSiCCDS15781.1.
RefSeqiNP_083569.1. NM_029293.2.
UniGeneiMm.458079.

Genome annotation databases

EnsembliENSMUST00000039156; ENSMUSP00000037417; ENSMUSG00000036504.
GeneIDi75454.
KEGGimmu:75454.
UCSCiuc008isp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005756 mRNA. Translation: BAB24222.1.
BC028657 mRNA. Translation: AAH28657.1.
CCDSiCCDS15781.1.
RefSeqiNP_083569.1. NM_029293.2.
UniGeneiMm.458079.

3D structure databases

ProteinModelPortaliQ9DAK9.
SMRiQ9DAK9. Positions 3-124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1855555.
STRINGi10090.ENSMUSP00000037417.

PTM databases

iPTMnetiQ9DAK9.
PhosphoSiteiQ9DAK9.

2D gel databases

REPRODUCTION-2DPAGEIPI00118757.
Q9DAK9.

Proteomic databases

EPDiQ9DAK9.
MaxQBiQ9DAK9.
PaxDbiQ9DAK9.
PRIDEiQ9DAK9.

Protocols and materials databases

DNASUi75454.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039156; ENSMUSP00000037417; ENSMUSG00000036504.
GeneIDi75454.
KEGGimmu:75454.
UCSCiuc008isp.1. mouse.

Organism-specific databases

CTDi29085.
MGIiMGI:1922704. Phpt1.

Phylogenomic databases

eggNOGiENOG410IZ5G. Eukaryota.
ENOG4111SA6. LUCA.
GeneTreeiENSGT00390000002738.
HOGENOMiHOG000231559.
HOVERGENiHBG053589.
InParanoidiQ9DAK9.
KOiK01112.
OMAiGWAEYHA.
OrthoDBiEOG7S2215.
PhylomeDBiQ9DAK9.
TreeFamiTF315158.

Miscellaneous databases

ChiTaRSiPhpt1. mouse.
NextBioi343056.
PROiQ9DAK9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DAK9.
CleanExiMM_PHPT1.
GenevisibleiQ9DAK9. MM.

Family and domain databases

InterProiIPR007702. Janus.
IPR028441. PHPT1.
[Graphical view]
PANTHERiPTHR12258:SF10. PTHR12258:SF10. 1 hit.
PfamiPF05005. Ocnus. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPHP14_MOUSE
AccessioniPrimary (citable) accession number: Q9DAK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.