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Protein

14 kDa phosphohistidine phosphatase

Gene

Phpt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits phosphohistidine phosphatase activity.By similarity

Catalytic activityi

A [protein]-N-phospho-L-histidine + H2O = a [protein]-L-histidine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20SubstrateBy similarity1
Active sitei52Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
14 kDa phosphohistidine phosphatase (EC:3.9.1.3By similarity)
Alternative name(s):
Phosphohistidine phosphatase 1
Short name:
PHPT1
Protein histidine phosphatase
Short name:
PHP
Gene namesi
Name:Phpt1
Synonyms:Php14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1922704 Phpt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061531 – 12414 kDa phosphohistidine phosphataseAdd BLAST124

Proteomic databases

EPDiQ9DAK9
MaxQBiQ9DAK9
PaxDbiQ9DAK9
PeptideAtlasiQ9DAK9
PRIDEiQ9DAK9

2D gel databases

REPRODUCTION-2DPAGEiIPI00118757
Q9DAK9

PTM databases

iPTMnetiQ9DAK9
PhosphoSitePlusiQ9DAK9

Expressioni

Gene expression databases

BgeeiENSMUSG00000036504
CleanExiMM_PHPT1
GenevisibleiQ9DAK9 MM

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037417

Structurei

3D structure databases

ProteinModelPortaliQ9DAK9
SMRiQ9DAK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 95Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the janus family.Curated

Phylogenomic databases

eggNOGiENOG410IZ5G Eukaryota
ENOG4111SA6 LUCA
GeneTreeiENSGT00390000002738
HOGENOMiHOG000231559
HOVERGENiHBG053589
InParanoidiQ9DAK9
KOiK01112
OMAiGWAEYHA
OrthoDBiEOG091G10Y7
PhylomeDBiQ9DAK9
TreeFamiTF315158

Family and domain databases

Gene3Di3.50.20.20, 1 hit
InterProiView protein in InterPro
IPR007702 Janus
IPR038596 Janus_sf
IPR028441 PHPT1
PANTHERiPTHR12258 PTHR12258, 1 hit
PTHR12258:SF10 PTHR12258:SF10, 1 hit
PfamiView protein in Pfam
PF05005 Ocnus, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DAK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADLGQIPD VDIDSDGVFK YVLIRVHLAE PSGDPAKECK EIVRGYKWAE
60 70 80 90 100
YHADIYDKVS GELQRNGYDC ECLGGGRISH QSQDRKIHVY GYSMGYGRAQ
110 120
HSVSTEKIKA KYPDYEVTWA DDGY
Length:124
Mass (Da):13,997
Last modified:June 1, 2001 - v1
Checksum:i583F9A3CE95A2F66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005756 mRNA Translation: BAB24222.1
BC028657 mRNA Translation: AAH28657.1
CCDSiCCDS15781.1
RefSeqiNP_083569.1, NM_029293.2
UniGeneiMm.458079

Genome annotation databases

EnsembliENSMUST00000039156; ENSMUSP00000037417; ENSMUSG00000036504
GeneIDi75454
KEGGimmu:75454
UCSCiuc008isp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPHP14_MOUSE
AccessioniPrimary (citable) accession number: Q9DAK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health