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Protein

Leucine-rich repeat-containing protein 51

Gene

Lrrc51

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 51
Alternative name(s):
Protein LRTOMT1
Gene namesi
Name:Lrrc51
Synonyms:Lrtomt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916608. Lrrc51.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002255011 – 192Leucine-rich repeat-containing protein 51Add BLAST192

Proteomic databases

PaxDbiQ9DAK8.
PRIDEiQ9DAK8.

PTM databases

PhosphoSitePlusiQ9DAK8.

Expressioni

Tissue specificityi

Widely expressed in adult and embryonic tissues. Expressed in the developing choroid plexus from E12.5 and in the epithelium of the developing airway tract from E14.5. Also expressed in the postnatal inner ear.1 Publication

Gene expression databases

BgeeiENSMUSG00000064307.
CleanExiMM_LRRC51.
ExpressionAtlasiQ9DAK8. baseline and differential.
GenevisibleiQ9DAK8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077543.

Structurei

3D structure databases

ProteinModelPortaliQ9DAK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 71LRR 1Add BLAST23
Repeati80 – 101LRR 2Add BLAST22
Repeati103 – 124LRR 3Add BLAST22
Domaini137 – 175LRRCTAdd BLAST39

Sequence similaritiesi

Contains 3 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1644. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00510000047925.
HOGENOMiHOG000067975.
HOVERGENiHBG055282.
InParanoidiQ9DAK8.
PhylomeDBiQ9DAK8.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DAK8-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSRDYMNTS VQEPPLDYSF KSVQMVQDLV TEEPRTGLRP VRHSKSGKSL
60 70 80 90 100
TQSLWLNNNV LNDLKDFNQV VSQLLQHPEN LAWIDLSFND LTTIDPVLTT
110 120 130 140 150
FFNLSVLYLH GNGIHRLGEV NKLAVLPRLR SLTLHGNPIE EEKGYRQYVL
160 170 180 190
CNLPRITTFD FSGVTRADRS TAEVWKRMGI KPKKVRAKQD VL
Length:192
Mass (Da):22,008
Last modified:June 1, 2001 - v1
Checksum:i8AA9D7074874AD52
GO
Isoform 2 (identifier: Q9DAK8-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     147-192: Missing.

Show »
Length:146
Mass (Da):16,702
Checksum:iB599B3FD91C6CD28
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036897147 – 192Missing in isoform 2. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU627089 mRNA. Translation: ACF40899.1.
EU627090 mRNA. Translation: ACF40900.1.
AK005758 mRNA. Translation: BAB24223.1.
CH466531 Genomic DNA. Translation: EDL16549.1.
CH466531 Genomic DNA. Translation: EDL16550.1.
CH466531 Genomic DNA. Translation: EDL16551.1.
BC025128 mRNA. Translation: AAH25128.1.
CCDSiCCDS52331.1. [Q9DAK8-2]
CCDS52332.1. [Q9DAK8-1]
RefSeqiNP_001156446.1. NM_001162974.1. [Q9DAK8-2]
NP_081329.1. NM_027053.1.
UniGeneiMm.214841.

Genome annotation databases

EnsembliENSMUST00000098236; ENSMUSP00000095838; ENSMUSG00000064307. [Q9DAK8-2]
ENSMUST00000106963; ENSMUSP00000102576; ENSMUSG00000064307. [Q9DAK8-2]
ENSMUST00000106964; ENSMUSP00000102577; ENSMUSG00000064307. [Q9DAK8-2]
ENSMUST00000163903; ENSMUSP00000129333; ENSMUSG00000064307. [Q9DAK8-2]
GeneIDi69358.
KEGGimmu:69358.
UCSCiuc009ipx.2. mouse. [Q9DAK8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU627089 mRNA. Translation: ACF40899.1.
EU627090 mRNA. Translation: ACF40900.1.
AK005758 mRNA. Translation: BAB24223.1.
CH466531 Genomic DNA. Translation: EDL16549.1.
CH466531 Genomic DNA. Translation: EDL16550.1.
CH466531 Genomic DNA. Translation: EDL16551.1.
BC025128 mRNA. Translation: AAH25128.1.
CCDSiCCDS52331.1. [Q9DAK8-2]
CCDS52332.1. [Q9DAK8-1]
RefSeqiNP_001156446.1. NM_001162974.1. [Q9DAK8-2]
NP_081329.1. NM_027053.1.
UniGeneiMm.214841.

3D structure databases

ProteinModelPortaliQ9DAK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077543.

PTM databases

PhosphoSitePlusiQ9DAK8.

Proteomic databases

PaxDbiQ9DAK8.
PRIDEiQ9DAK8.

Protocols and materials databases

DNASUi69358.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098236; ENSMUSP00000095838; ENSMUSG00000064307. [Q9DAK8-2]
ENSMUST00000106963; ENSMUSP00000102576; ENSMUSG00000064307. [Q9DAK8-2]
ENSMUST00000106964; ENSMUSP00000102577; ENSMUSG00000064307. [Q9DAK8-2]
ENSMUST00000163903; ENSMUSP00000129333; ENSMUSG00000064307. [Q9DAK8-2]
GeneIDi69358.
KEGGimmu:69358.
UCSCiuc009ipx.2. mouse. [Q9DAK8-1]

Organism-specific databases

CTDi69358.
MGIiMGI:1916608. Lrrc51.

Phylogenomic databases

eggNOGiKOG1644. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00510000047925.
HOGENOMiHOG000067975.
HOVERGENiHBG055282.
InParanoidiQ9DAK8.
PhylomeDBiQ9DAK8.

Miscellaneous databases

PROiQ9DAK8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064307.
CleanExiMM_LRRC51.
ExpressionAtlasiQ9DAK8. baseline and differential.
GenevisibleiQ9DAK8. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC51_MOUSE
AccessioniPrimary (citable) accession number: Q9DAK8
Secondary accession number(s): B6CZ58, B6CZ59, Q8R171
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In primates, this protein is produced by a bicistronic gene which also produces the TOMT protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.