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Protein

Fatty acid-binding protein 12

Gene

Fabp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in lipid transport.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071Fatty acidBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein 12
Gene namesi
Name:Fabp12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1922747. Fabp12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Fatty acid-binding protein 12PRO_0000342882Add
BLAST

Proteomic databases

EPDiQ9DAK4.
PaxDbiQ9DAK4.
PRIDEiQ9DAK4.

PTM databases

PhosphoSiteiQ9DAK4.

Expressioni

Tissue specificityi

Highly expressed in adult retina and testis.1 Publication

Gene expression databases

BgeeiQ9DAK4.
GenevisibleiQ9DAK4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029043.

Structurei

3D structure databases

ProteinModelPortaliQ9DAK4.
SMRiQ9DAK4. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ9DAK4.
OMAiDNDAMIH.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ9DAK4.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031261. FABP12.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF76. PTHR11955:SF76. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DAK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDQLQGTWK SVSCDNFENY MKELGVGRAS RKLGCLAKPT VTISTDGDLI
60 70 80 90 100
TIKTKSIFKN KEISFKLGEE FEETTPSGRK SKSTVILDND SLVQVQDWDG
110 120 130
KEATICRRLV DGKMVVESAV NNVTCTRTYQ RV
Length:132
Mass (Da):14,758
Last modified:June 1, 2001 - v1
Checksum:i7A20C53780845F61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU733649 mRNA. Translation: ACI03639.1.
AK005765 mRNA. Translation: BAB24227.1.
CH466577 Genomic DNA. Translation: EDL05167.1.
CH466577 Genomic DNA. Translation: EDL05168.1.
BC030910 mRNA. Translation: AAH30910.1.
CCDSiCCDS17239.1.
RefSeqiNP_083586.1. NM_029310.1.
XP_006530156.1. XM_006530093.2.
XP_006530157.1. XM_006530094.2.
XP_006530158.1. XM_006530095.2.
XP_006530159.1. XM_006530096.2.
XP_006530160.1. XM_006530097.2.
XP_006530162.1. XM_006530099.2.
XP_011246451.1. XM_011248149.1.
UniGeneiMm.47052.

Genome annotation databases

EnsembliENSMUST00000029043; ENSMUSP00000029043; ENSMUSG00000027530.
ENSMUST00000117917; ENSMUSP00000112464; ENSMUSG00000027530.
ENSMUST00000119761; ENSMUSP00000112958; ENSMUSG00000027530.
ENSMUST00000172126; ENSMUSP00000131101; ENSMUSG00000027530.
GeneIDi75497.
KEGGimmu:75497.
UCSCiuc008opm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU733649 mRNA. Translation: ACI03639.1.
AK005765 mRNA. Translation: BAB24227.1.
CH466577 Genomic DNA. Translation: EDL05167.1.
CH466577 Genomic DNA. Translation: EDL05168.1.
BC030910 mRNA. Translation: AAH30910.1.
CCDSiCCDS17239.1.
RefSeqiNP_083586.1. NM_029310.1.
XP_006530156.1. XM_006530093.2.
XP_006530157.1. XM_006530094.2.
XP_006530158.1. XM_006530095.2.
XP_006530159.1. XM_006530096.2.
XP_006530160.1. XM_006530097.2.
XP_006530162.1. XM_006530099.2.
XP_011246451.1. XM_011248149.1.
UniGeneiMm.47052.

3D structure databases

ProteinModelPortaliQ9DAK4.
SMRiQ9DAK4. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029043.

PTM databases

PhosphoSiteiQ9DAK4.

Proteomic databases

EPDiQ9DAK4.
PaxDbiQ9DAK4.
PRIDEiQ9DAK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029043; ENSMUSP00000029043; ENSMUSG00000027530.
ENSMUST00000117917; ENSMUSP00000112464; ENSMUSG00000027530.
ENSMUST00000119761; ENSMUSP00000112958; ENSMUSG00000027530.
ENSMUST00000172126; ENSMUSP00000131101; ENSMUSG00000027530.
GeneIDi75497.
KEGGimmu:75497.
UCSCiuc008opm.1. mouse.

Organism-specific databases

CTDi646486.
MGIiMGI:1922747. Fabp12.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ9DAK4.
OMAiDNDAMIH.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ9DAK4.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

NextBioi343174.
PROiQ9DAK4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DAK4.
GenevisibleiQ9DAK4. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031261. FABP12.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF76. PTHR11955:SF76. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis."
    Liu R.Z., Li X., Godbout R.
    Genomics 92:436-445(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Retina.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.

Entry informationi

Entry nameiFBP12_MOUSE
AccessioniPrimary (citable) accession number: Q9DAK4
Secondary accession number(s): B7SUM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.