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Protein

Rho-related BTB domain-containing protein 1

Gene

Rhobtb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 288GTPSequence Analysis
Nucleotide bindingi84 – 885GTPSequence Analysis
Nucleotide bindingi140 – 1434GTPSequence Analysis

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_297947. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 1
Gene namesi
Name:Rhobtb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1916538. Rhobtb1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Rho-related BTB domain-containing protein 1PRO_0000198961Add
BLAST

Proteomic databases

MaxQBiQ9DAK3.
PRIDEiQ9DAK3.

PTM databases

PhosphoSiteiQ9DAK3.

Expressioni

Tissue specificityi

Highest expression in heart and testis.1 Publication

Gene expression databases

BgeeiQ9DAK3.
CleanExiMM_RHOBTB1.
ExpressionAtlasiQ9DAK3. baseline and differential.
GenevestigatoriQ9DAK3.

Interactioni

Protein-protein interaction databases

BioGridi213337. 5 interactions.
STRINGi10090.ENSMUSP00000020101.

Structurei

3D structure databases

ProteinModelPortaliQ9DAK3.
SMRiQ9DAK3. Positions 13-208, 468-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini266 – 426161BTB 1PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 55168BTB 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 210210Rho-likeAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated
Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000007723.
HOVERGENiHBG054987.
InParanoidiQ9DAK3.
KOiK07868.
OMAiLMECEET.
OrthoDBiEOG7SXW2N.
PhylomeDBiQ9DAK3.
TreeFamiTF323347.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00225. BTB. 2 hits.
SM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV
60 70 80 90 100
PTVWAIDQYR VCQEVLERSR DVVDEVSISL RLWDTFGDHH KDRRFAYGRS
110 120 130 140 150
DVVVLCFSIA NPNSLNHVKT MWYQEIKHFC PRTPVVLVGC QLDLRYADLE
160 170 180 190 200
AVNRARRPLA RPIKRGDILP PEKGREVAKE LGIPYYETSV FDQFGIKDVF
210 220 230 240 250
DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP PVIKVPECPS
260 270 280 290 300
AGTSDAACLL DNPLCADVLF VLHDEEHIFA HRIYLATSSS KFYDLFLMEC
310 320 330 340 350
EESPCWGGGA GEEVPCRDFQ GRTQSLGSAE EGKEGPQRTP QADPGASSGQ
360 370 380 390 400
DLPESLALQM EASGSEGHAL SGWSKGFVSM HREVRVNPIS KRVGPVTVVR
410 420 430 440 450
LDPSMQSGPF RTLLRFLYSG QLDEKEKDLL GLAQMAEVLE MFDLRMMVEN
460 470 480 490 500
IMNKEAFMNQ EITKAFHVRK ANRIKECLSK GTFSDVTFTL DDGAISAHKP
510 520 530 540 550
LLICSCEWMA AMFGGSFVES ANREVHLPNI NKMSMQAVLE YLYTKQLSPN
560 570 580 590 600
LDLDPLELIA LANRFCLTHL VALVEQHAVQ ELTKAAVSGV SIDGEVLSYL
610 620 630 640 650
ELAQFHNANQ LAAWCLHHIC TNYNSVCSKF RKEIKSKSAD NQEYFERHRW
660 670 680 690
PPVWYLKEED HYQRVKRERE KEDLALNKHH SRRKWCFWHS SPAVA
Length:695
Mass (Da):78,819
Last modified:July 27, 2011 - v2
Checksum:iAA5F75C033004641
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti636 – 6361S → Y in BAB24229 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005770 mRNA. Translation: BAB24229.1.
CH466553 Genomic DNA. Translation: EDL32000.1.
CH466553 Genomic DNA. Translation: EDL32001.1.
CH466553 Genomic DNA. Translation: EDL32002.1.
CH466553 Genomic DNA. Translation: EDL32003.1.
CH466553 Genomic DNA. Translation: EDL32004.1.
BC137646 mRNA. Translation: AAI37647.1.
BC137647 mRNA. Translation: AAI37648.1.
CCDSiCCDS35930.1.
RefSeqiNP_001074816.1. NM_001081347.1.
NP_001239565.1. NM_001252636.1.
NP_001239566.1. NM_001252637.1.
XP_006514111.1. XM_006514048.2.
XP_006514112.1. XM_006514049.2.
XP_006514114.1. XM_006514051.2.
UniGeneiMm.26659.

Genome annotation databases

EnsembliENSMUST00000020101; ENSMUSP00000020101; ENSMUSG00000019944.
ENSMUST00000067908; ENSMUSP00000065095; ENSMUSG00000019944.
ENSMUST00000164034; ENSMUSP00000132068; ENSMUSG00000019944.
GeneIDi69288.
KEGGimmu:69288.
UCSCiuc007fmp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005770 mRNA. Translation: BAB24229.1.
CH466553 Genomic DNA. Translation: EDL32000.1.
CH466553 Genomic DNA. Translation: EDL32001.1.
CH466553 Genomic DNA. Translation: EDL32002.1.
CH466553 Genomic DNA. Translation: EDL32003.1.
CH466553 Genomic DNA. Translation: EDL32004.1.
BC137646 mRNA. Translation: AAI37647.1.
BC137647 mRNA. Translation: AAI37648.1.
CCDSiCCDS35930.1.
RefSeqiNP_001074816.1. NM_001081347.1.
NP_001239565.1. NM_001252636.1.
NP_001239566.1. NM_001252637.1.
XP_006514111.1. XM_006514048.2.
XP_006514112.1. XM_006514049.2.
XP_006514114.1. XM_006514051.2.
UniGeneiMm.26659.

3D structure databases

ProteinModelPortaliQ9DAK3.
SMRiQ9DAK3. Positions 13-208, 468-576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213337. 5 interactions.
STRINGi10090.ENSMUSP00000020101.

PTM databases

PhosphoSiteiQ9DAK3.

Proteomic databases

MaxQBiQ9DAK3.
PRIDEiQ9DAK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020101; ENSMUSP00000020101; ENSMUSG00000019944.
ENSMUST00000067908; ENSMUSP00000065095; ENSMUSG00000019944.
ENSMUST00000164034; ENSMUSP00000132068; ENSMUSG00000019944.
GeneIDi69288.
KEGGimmu:69288.
UCSCiuc007fmp.1. mouse.

Organism-specific databases

CTDi9886.
MGIiMGI:1916538. Rhobtb1.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000007723.
HOVERGENiHBG054987.
InParanoidiQ9DAK3.
KOiK07868.
OMAiLMECEET.
OrthoDBiEOG7SXW2N.
PhylomeDBiQ9DAK3.
TreeFamiTF323347.

Enzyme and pathway databases

ReactomeiREACT_297947. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiRhobtb1. mouse.
NextBioi329043.
PROiQ9DAK3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DAK3.
CleanExiMM_RHOBTB1.
ExpressionAtlasiQ9DAK3. baseline and differential.
GenevestigatoriQ9DAK3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00225. BTB. 2 hits.
SM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse."
    Ramos S., Khademi F., Somesh B.P., Rivero F.
    Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 401-411, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiRHBT1_MOUSE
AccessioniPrimary (citable) accession number: Q9DAK3
Secondary accession number(s): B2RPX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.