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Q9DAK3

- RHBT1_MOUSE

UniProt

Q9DAK3 - RHBT1_MOUSE

Protein

Rho-related BTB domain-containing protein 1

Gene

Rhobtb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 288GTPSequence Analysis
    Nucleotide bindingi84 – 885GTPSequence Analysis
    Nucleotide bindingi140 – 1434GTPSequence Analysis

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. protein binding Source: MGI

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_210090. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho-related BTB domain-containing protein 1
    Gene namesi
    Name:Rhobtb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1916538. Rhobtb1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695Rho-related BTB domain-containing protein 1PRO_0000198961Add
    BLAST

    Proteomic databases

    PRIDEiQ9DAK3.

    PTM databases

    PhosphoSiteiQ9DAK3.

    Expressioni

    Tissue specificityi

    Highest expression in heart and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9DAK3.
    BgeeiQ9DAK3.
    CleanExiMM_RHOBTB1.
    GenevestigatoriQ9DAK3.

    Interactioni

    Protein-protein interaction databases

    BioGridi213337. 5 interactions.
    STRINGi10090.ENSMUSP00000020101.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DAK3.
    SMRiQ9DAK3. Positions 13-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini266 – 426161BTB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 55168BTB 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 210210Rho-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.Curated
    Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00720000108472.
    HOGENOMiHOG000007723.
    HOVERGENiHBG054987.
    InParanoidiB2RPX3.
    KOiK07868.
    OMAiCADVLFV.
    OrthoDBiEOG7SXW2N.
    PhylomeDBiQ9DAK3.
    TreeFamiTF323347.

    Family and domain databases

    Gene3Di3.30.710.10. 3 hits.
    3.40.50.300. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00225. BTB. 2 hits.
    SM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF54695. SSF54695. 3 hits.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS50097. BTB. 2 hits.
    PS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DAK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV    50
    PTVWAIDQYR VCQEVLERSR DVVDEVSISL RLWDTFGDHH KDRRFAYGRS 100
    DVVVLCFSIA NPNSLNHVKT MWYQEIKHFC PRTPVVLVGC QLDLRYADLE 150
    AVNRARRPLA RPIKRGDILP PEKGREVAKE LGIPYYETSV FDQFGIKDVF 200
    DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP PVIKVPECPS 250
    AGTSDAACLL DNPLCADVLF VLHDEEHIFA HRIYLATSSS KFYDLFLMEC 300
    EESPCWGGGA GEEVPCRDFQ GRTQSLGSAE EGKEGPQRTP QADPGASSGQ 350
    DLPESLALQM EASGSEGHAL SGWSKGFVSM HREVRVNPIS KRVGPVTVVR 400
    LDPSMQSGPF RTLLRFLYSG QLDEKEKDLL GLAQMAEVLE MFDLRMMVEN 450
    IMNKEAFMNQ EITKAFHVRK ANRIKECLSK GTFSDVTFTL DDGAISAHKP 500
    LLICSCEWMA AMFGGSFVES ANREVHLPNI NKMSMQAVLE YLYTKQLSPN 550
    LDLDPLELIA LANRFCLTHL VALVEQHAVQ ELTKAAVSGV SIDGEVLSYL 600
    ELAQFHNANQ LAAWCLHHIC TNYNSVCSKF RKEIKSKSAD NQEYFERHRW 650
    PPVWYLKEED HYQRVKRERE KEDLALNKHH SRRKWCFWHS SPAVA 695
    Length:695
    Mass (Da):78,819
    Last modified:July 27, 2011 - v2
    Checksum:iAA5F75C033004641
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti636 – 6361S → Y in BAB24229. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005770 mRNA. Translation: BAB24229.1.
    CH466553 Genomic DNA. Translation: EDL32000.1.
    CH466553 Genomic DNA. Translation: EDL32001.1.
    CH466553 Genomic DNA. Translation: EDL32002.1.
    CH466553 Genomic DNA. Translation: EDL32003.1.
    CH466553 Genomic DNA. Translation: EDL32004.1.
    BC137646 mRNA. Translation: AAI37647.1.
    BC137647 mRNA. Translation: AAI37648.1.
    CCDSiCCDS35930.1.
    RefSeqiNP_001074816.1. NM_001081347.1.
    NP_001239565.1. NM_001252636.1.
    NP_001239566.1. NM_001252637.1.
    XP_006514111.1. XM_006514048.1.
    XP_006514112.1. XM_006514049.1.
    XP_006514113.1. XM_006514050.1.
    XP_006514114.1. XM_006514051.1.
    UniGeneiMm.26659.

    Genome annotation databases

    EnsembliENSMUST00000020101; ENSMUSP00000020101; ENSMUSG00000019944.
    ENSMUST00000067908; ENSMUSP00000065095; ENSMUSG00000019944.
    ENSMUST00000164034; ENSMUSP00000132068; ENSMUSG00000019944.
    GeneIDi69288.
    KEGGimmu:69288.
    UCSCiuc007fmp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005770 mRNA. Translation: BAB24229.1 .
    CH466553 Genomic DNA. Translation: EDL32000.1 .
    CH466553 Genomic DNA. Translation: EDL32001.1 .
    CH466553 Genomic DNA. Translation: EDL32002.1 .
    CH466553 Genomic DNA. Translation: EDL32003.1 .
    CH466553 Genomic DNA. Translation: EDL32004.1 .
    BC137646 mRNA. Translation: AAI37647.1 .
    BC137647 mRNA. Translation: AAI37648.1 .
    CCDSi CCDS35930.1.
    RefSeqi NP_001074816.1. NM_001081347.1.
    NP_001239565.1. NM_001252636.1.
    NP_001239566.1. NM_001252637.1.
    XP_006514111.1. XM_006514048.1.
    XP_006514112.1. XM_006514049.1.
    XP_006514113.1. XM_006514050.1.
    XP_006514114.1. XM_006514051.1.
    UniGenei Mm.26659.

    3D structure databases

    ProteinModelPortali Q9DAK3.
    SMRi Q9DAK3. Positions 13-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 213337. 5 interactions.
    STRINGi 10090.ENSMUSP00000020101.

    PTM databases

    PhosphoSitei Q9DAK3.

    Proteomic databases

    PRIDEi Q9DAK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020101 ; ENSMUSP00000020101 ; ENSMUSG00000019944 .
    ENSMUST00000067908 ; ENSMUSP00000065095 ; ENSMUSG00000019944 .
    ENSMUST00000164034 ; ENSMUSP00000132068 ; ENSMUSG00000019944 .
    GeneIDi 69288.
    KEGGi mmu:69288.
    UCSCi uc007fmp.1. mouse.

    Organism-specific databases

    CTDi 9886.
    MGIi MGI:1916538. Rhobtb1.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00720000108472.
    HOGENOMi HOG000007723.
    HOVERGENi HBG054987.
    InParanoidi B2RPX3.
    KOi K07868.
    OMAi CADVLFV.
    OrthoDBi EOG7SXW2N.
    PhylomeDBi Q9DAK3.
    TreeFami TF323347.

    Enzyme and pathway databases

    Reactomei REACT_210090. Rho GTPase cycle.

    Miscellaneous databases

    NextBioi 329043.
    PROi Q9DAK3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DAK3.
    Bgeei Q9DAK3.
    CleanExi MM_RHOBTB1.
    Genevestigatori Q9DAK3.

    Family and domain databases

    Gene3Di 3.30.710.10. 3 hits.
    3.40.50.300. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00225. BTB. 2 hits.
    SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF54695. SSF54695. 3 hits.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS50097. BTB. 2 hits.
    PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse."
      Ramos S., Khademi F., Somesh B.P., Rivero F.
      Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 401-411, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiRHBT1_MOUSE
    AccessioniPrimary (citable) accession number: Q9DAK3
    Secondary accession number(s): B2RPX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3