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Q9DAK3 (RHBT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho-related BTB domain-containing protein 1
Gene names
Name:Rhobtb1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Highest expression in heart and testis. Ref.1

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Contains 2 BTB (POZ) domains.

Ontologies

Keywords
   DomainRepeat
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processsmall GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 695695Rho-related BTB domain-containing protein 1
PRO_0000198961

Regions

Domain266 – 426161BTB 1
Domain484 – 55168BTB 2
Nucleotide binding21 – 288GTP Potential
Nucleotide binding84 – 885GTP Potential
Nucleotide binding140 – 1434GTP Potential
Region1 – 210210Rho-like

Experimental info

Sequence conflict6361S → Y in BAB24229. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9DAK3 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: AA5F75C033004641

FASTA69578,819
        10         20         30         40         50         60 
MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV PTVWAIDQYR 

        70         80         90        100        110        120 
VCQEVLERSR DVVDEVSISL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLNHVKT 

       130        140        150        160        170        180 
MWYQEIKHFC PRTPVVLVGC QLDLRYADLE AVNRARRPLA RPIKRGDILP PEKGREVAKE 

       190        200        210        220        230        240 
LGIPYYETSV FDQFGIKDVF DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP 

       250        260        270        280        290        300 
PVIKVPECPS AGTSDAACLL DNPLCADVLF VLHDEEHIFA HRIYLATSSS KFYDLFLMEC 

       310        320        330        340        350        360 
EESPCWGGGA GEEVPCRDFQ GRTQSLGSAE EGKEGPQRTP QADPGASSGQ DLPESLALQM 

       370        380        390        400        410        420 
EASGSEGHAL SGWSKGFVSM HREVRVNPIS KRVGPVTVVR LDPSMQSGPF RTLLRFLYSG 

       430        440        450        460        470        480 
QLDEKEKDLL GLAQMAEVLE MFDLRMMVEN IMNKEAFMNQ EITKAFHVRK ANRIKECLSK 

       490        500        510        520        530        540 
GTFSDVTFTL DDGAISAHKP LLICSCEWMA AMFGGSFVES ANREVHLPNI NKMSMQAVLE 

       550        560        570        580        590        600 
YLYTKQLSPN LDLDPLELIA LANRFCLTHL VALVEQHAVQ ELTKAAVSGV SIDGEVLSYL 

       610        620        630        640        650        660 
ELAQFHNANQ LAAWCLHHIC TNYNSVCSKF RKEIKSKSAD NQEYFERHRW PPVWYLKEED 

       670        680        690 
HYQRVKRERE KEDLALNKHH SRRKWCFWHS SPAVA

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse."
Ramos S., Khademi F., Somesh B.P., Rivero F.
Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 401-411, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK005770 mRNA. Translation: BAB24229.1.
CH466553 Genomic DNA. Translation: EDL32000.1.
CH466553 Genomic DNA. Translation: EDL32001.1.
CH466553 Genomic DNA. Translation: EDL32002.1.
CH466553 Genomic DNA. Translation: EDL32003.1.
CH466553 Genomic DNA. Translation: EDL32004.1.
BC137646 mRNA. Translation: AAI37647.1.
BC137647 mRNA. Translation: AAI37648.1.
IPIIPI00118748.
RefSeqNP_001074816.1. NM_001081347.1.
NP_001239565.1. NM_001252636.1.
NP_001239566.1. NM_001252637.1.
UniGeneMm.26659.

3D structure databases

ProteinModelPortalQ9DAK3.
SMRQ9DAK3. Positions 13-208.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000020101.

PTM databases

PhosphoSiteQ9DAK3.

Proteomic databases

PRIDEQ9DAK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020101; ENSMUSP00000020101; ENSMUSG00000019944.
ENSMUST00000067908; ENSMUSP00000065095; ENSMUSG00000019944.
ENSMUST00000164034; ENSMUSP00000132068; ENSMUSG00000019944.
GeneID69288.
KEGGmmu:69288.

Organism-specific databases

CTD9886.
MGIMGI:1916538. Rhobtb1.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00680000099621.
HOGENOMHOG000007723.
HOVERGENHBG054987.
InParanoidB2RPX3.
KOK07868.
OMADLFLMEC.
OrthoDBEOG479F6M.

Gene expression databases

ArrayExpressQ9DAK3.
BgeeQ9DAK3.
CleanExMM_RHOBTB1.
GenevestigatorQ9DAK3.
GermOnlineENSMUSG00000019944. Mus musculus.

Family and domain databases

Gene3D3.30.710.10. 3 hits.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00225. BTB. 2 hits.
SM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 2 hits.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio329043.
SOURCESearch...

Entry information

Entry nameRHBT1_MOUSE
AccessionPrimary (citable) accession number: Q9DAK3
Secondary accession number(s): B2RPX3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents