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Protein

Dynein light chain roadblock-type 2

Gene

Dynlrb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain roadblock-type 2
Alternative name(s):
Dynein light chain 2B, cytoplasmic
Gene namesi
Name:Dynlrb2
Synonyms:Dncl2b, Dnlc2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1922715. Dynlrb2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209591 – 96Dynein light chain roadblock-type 2Add BLAST96

Proteomic databases

PaxDbiQ9DAJ5.
PeptideAtlasiQ9DAJ5.
PRIDEiQ9DAJ5.

PTM databases

PhosphoSitePlusiQ9DAJ5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034467.
CleanExiMM_DYNLRB2.
GenevisibleiQ9DAJ5. MM.

Interactioni

Subunit structurei

Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB1 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217500. 1 interactor.
IntActiQ9DAJ5. 2 interactors.
STRINGi10090.ENSMUSP00000077301.

Structurei

3D structure databases

ProteinModelPortaliQ9DAJ5.
SMRiQ9DAJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4115. Eukaryota.
ENOG4111NDV. LUCA.
GeneTreeiENSGT00390000011067.
HOGENOMiHOG000232033.
HOVERGENiHBG058598.
InParanoidiQ9DAJ5.
KOiK10419.
OMAiTIIRHSG.
OrthoDBiEOG091G155M.
PhylomeDBiQ9DAJ5.
TreeFamiTF315165.

Family and domain databases

InterProiView protein in InterPro
IPR016561. DYNLRB1/2.
IPR004942. Roadblock/LAMTOR2_dom.
PfamiView protein in Pfam
PF03259. Robl_LC7. 1 hit.
PIRSFiPIRSF009998. DLC7. 1 hit.
SMARTiView protein in SMART
SM00960. Robl_LC7. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DAJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEVEETLKR IQSHKGVIGT MVVNAEGIPI RTTLDNSTTV QYAGLLHQLT
60 70 80 90
MKAKSTVRDI DPQNDLTFLR IRSKKHEIMV APDKEYLLIV IQNPCE
Length:96
Mass (Da):10,876
Last modified:June 1, 2001 - v1
Checksum:i5C446A9D0E815775
GO
Isoform 2 (identifier: Q9DAJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-96: DKEYLLIVIQNPCE → EPM

Note: No experimental confirmation available.
Show »
Length:85
Mass (Da):9,574
Checksum:i0FBE9771068A49EB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00723883 – 96DKEYL…QNPCE → EPM in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005789 mRNA. Translation: BAB24240.1.
BC048623 mRNA. Translation: AAH48623.1.
CCDSiCCDS40487.1. [Q9DAJ5-1]
RefSeqiNP_083573.1. NM_029297.1. [Q9DAJ5-1]
UniGeneiMm.23114.

Genome annotation databases

EnsembliENSMUST00000078170; ENSMUSP00000077301; ENSMUSG00000034467. [Q9DAJ5-1]
ENSMUST00000213007; ENSMUSP00000148749; ENSMUSG00000034467. [Q9DAJ5-2]
GeneIDi75465.
KEGGimmu:75465.
UCSCiuc009nog.1. mouse. [Q9DAJ5-1]
uc009noh.1. mouse. [Q9DAJ5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDLRB2_MOUSE
AccessioniPrimary (citable) accession number: Q9DAJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families