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Protein

Zinc finger and BTB domain-containing protein 43

Gene

Zbtb43

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 43
Alternative name(s):
Zinc finger protein 297B
Gene namesi
Name:Zbtb43
Synonyms:Kiaa0414, Zfp297b, Znf297b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919084. Zbtb43.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475201 – 467Zinc finger and BTB domain-containing protein 43Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki247Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei423PhosphothreonineBy similarity1
Cross-linki458Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9DAI4.
PRIDEiQ9DAI4.

PTM databases

PhosphoSitePlusiQ9DAI4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026788.
CleanExiMM_ZBTB43.
ExpressionAtlasiQ9DAI4. baseline and differential.
GenevisibleiQ9DAI4. MM.

Interactioni

Subunit structurei

Interacts with BDP1.By similarity

Protein-protein interaction databases

BioGridi214963. 2 interactors.
IntActiQ9DAI4. 1 interactor.
STRINGi10090.ENSMUSP00000092645.

Structurei

3D structure databases

ProteinModelPortaliQ9DAI4.
SMRiQ9DAI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231975.
HOVERGENiHBG056510.
InParanoidiQ9DAI4.
KOiK10514.
PhylomeDBiQ9DAI4.
TreeFamiTF333162.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR029833. ZBT22/43.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24414:SF4. PTHR24414:SF4. 2 hits.
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGTNSFQV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFQAHKAV
60 70 80 90 100
LAASSPYFCD QVLLKNSRRI VLPDVMNPRV FENILLFSYT GRLVMPAPEI
110 120 130 140 150
VSYLTAASFL QMWHVVDKCT EVLEGNPTVL CQKLNHGSDH QSPSSSNYNG
160 170 180 190 200
LVESFELGSG GHTDFPKAQE LRDGENEEES TKDELSSQVT EHEYLPSNSS
210 220 230 240 250
TEHDRLSTEM ASQDGEEGTN DSTEFHYTRP LYSKPSIMAH RRWIHVKPER
260 270 280 290 300
LEQAWDGMDV HAAYDEHQVT ESVNTMQTDH SAQPSGAEEE FQIVEKKVEV
310 320 330 340 350
EFDEQAEGSS YDEQVDFYGS SMEEFSGEKL GGNLIGHKQE AALAAGYSEN
360 370 380 390 400
IEMAMGIKEE ASHLGFSATD KLYPCQCGKS FTHKSQRDRH MSMHLGLRPY
410 420 430 440 450
GCSVCGKKFK MKHHLVGHMK IHTGIKPYEC NICAKRFMWR DSFHRHVTSC
460
TKSYEAAKAE QNTTEAN
Length:467
Mass (Da):52,652
Last modified:May 16, 2003 - v2
Checksum:i79F7882A93128110
GO

Sequence cautioni

The sequence BAB24254 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65559 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti258M → T in BAB24254 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005818 mRNA. Translation: BAB24254.2. Different initiation.
AK122277 mRNA. Translation: BAC65559.1. Different initiation.
BC043117 mRNA. Translation: AAH43117.1.
CCDSiCCDS15943.1.
RefSeqiNP_001020765.1. NM_001025594.1.
NP_082223.2. NM_027947.2.
XP_006498411.1. XM_006498348.3.
XP_006498412.1. XM_006498349.2.
UniGeneiMm.44186.

Genome annotation databases

EnsembliENSMUST00000028125; ENSMUSP00000028125; ENSMUSG00000026788.
GeneIDi71834.
KEGGimmu:71834.
UCSCiuc008jhw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005818 mRNA. Translation: BAB24254.2. Different initiation.
AK122277 mRNA. Translation: BAC65559.1. Different initiation.
BC043117 mRNA. Translation: AAH43117.1.
CCDSiCCDS15943.1.
RefSeqiNP_001020765.1. NM_001025594.1.
NP_082223.2. NM_027947.2.
XP_006498411.1. XM_006498348.3.
XP_006498412.1. XM_006498349.2.
UniGeneiMm.44186.

3D structure databases

ProteinModelPortaliQ9DAI4.
SMRiQ9DAI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214963. 2 interactors.
IntActiQ9DAI4. 1 interactor.
STRINGi10090.ENSMUSP00000092645.

PTM databases

PhosphoSitePlusiQ9DAI4.

Proteomic databases

PaxDbiQ9DAI4.
PRIDEiQ9DAI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028125; ENSMUSP00000028125; ENSMUSG00000026788.
GeneIDi71834.
KEGGimmu:71834.
UCSCiuc008jhw.1. mouse.

Organism-specific databases

CTDi23099.
MGIiMGI:1919084. Zbtb43.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231975.
HOVERGENiHBG056510.
InParanoidiQ9DAI4.
KOiK10514.
PhylomeDBiQ9DAI4.
TreeFamiTF333162.

Miscellaneous databases

PROiQ9DAI4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026788.
CleanExiMM_ZBTB43.
ExpressionAtlasiQ9DAI4. baseline and differential.
GenevisibleiQ9DAI4. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR029833. ZBT22/43.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24414:SF4. PTHR24414:SF4. 2 hits.
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT43_MOUSE
AccessioniPrimary (citable) accession number: Q9DAI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 16, 2003
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.