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Protein

PHD finger protein 7

Gene

Phf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in spermatogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 68C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri96 – 145PHD-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri160 – 208RING-type; degenerateAdd BLAST49

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 7
Alternative name(s):
Testis development protein NYD-SP6
Gene namesi
Name:Phf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1919088. Phf7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559971 – 307PHD finger protein 7Add BLAST307

Proteomic databases

PaxDbiQ9DAG9.
PRIDEiQ9DAG9.

PTM databases

PhosphoSitePlusiQ9DAG9.

Expressioni

Tissue specificityi

Highly expressed in Sertoli cells in testis.1 Publication

Developmental stagei

Expression levels increase during the first 4 weeks after birth and remain constant during the following 3 weeks.1 Publication

Gene expression databases

BgeeiENSMUSG00000021902.
CleanExiMM_PHF7.
ExpressionAtlasiQ9DAG9. baseline and differential.
GenevisibleiQ9DAG9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022459.

Structurei

Secondary structure

1307
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi263 – 266Combined sources4
Beta strandi274 – 276Combined sources3
Helixi284 – 286Combined sources3
Turni298 – 300Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEQNMR-A232-303[»]
ProteinModelPortaliQ9DAG9.
SMRiQ9DAG9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DAG9.

Family & Domainsi

Sequence similaritiesi

Contains 1 C2HC pre-PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 68C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri96 – 145PHD-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri160 – 208RING-type; degenerateAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00390000005246.
HOGENOMiHOG000236336.
HOVERGENiHBG053588.
InParanoidiQ9DAG9.
OMAiCLYEQGR.
OrthoDBiEOG091G0Q24.
PhylomeDBiQ9DAG9.
TreeFamiTF325426.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DAG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTLKEKNKH PRLRKTIRTK KVTQRKLSSS PVCLLCLQEP GDPEKLGEFL
60 70 80 90 100
QKDNLCVHYF CLILSSRLPQ KGQPNRGLHG FMPEDIKREA VRASKKICFV
110 120 130 140 150
CKKKGAAIRC QNDQCVQNFH LPCGQERGCL SQFFGEYKSY CRKHRPTQNI
160 170 180 190 200
HQGSLGEESC VLCCENLSRT SVENIQSPCC SQAIYHRKCI QKYAHTSAKH
210 220 230 240 250
FFKCPQCNNR EEFPQEMLRM GIHIPDRDAA WELEPGAFSE LYQRYRHCDA
260 270 280 290 300
PICLYEQGRD SFEDEGRWRL ILCATCGSHG THRDCSSLRP NSKKWECNEC

LPASTTS
Length:307
Mass (Da):35,381
Last modified:June 1, 2001 - v1
Checksum:iB838B4CE2ED20BBA
GO
Isoform 2 (identifier: Q9DAG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-266: Missing.

Note: No experimental confirmation available.
Show »
Length:268
Mass (Da):30,831
Checksum:i393D959DBBED305F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013491228 – 266Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005852 mRNA. Translation: BAB24275.1.
BC057174 mRNA. Translation: AAH57174.1.
CCDSiCCDS26909.1. [Q9DAG9-1]
RefSeqiNP_082225.1. NM_027949.1. [Q9DAG9-1]
XP_006519646.1. XM_006519583.3. [Q9DAG9-2]
UniGeneiMm.5348.

Genome annotation databases

EnsembliENSMUST00000022459; ENSMUSP00000022459; ENSMUSG00000021902. [Q9DAG9-1]
GeneIDi71838.
KEGGimmu:71838.
UCSCiuc007sxf.1. mouse. [Q9DAG9-1]
uc007sxg.1. mouse. [Q9DAG9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005852 mRNA. Translation: BAB24275.1.
BC057174 mRNA. Translation: AAH57174.1.
CCDSiCCDS26909.1. [Q9DAG9-1]
RefSeqiNP_082225.1. NM_027949.1. [Q9DAG9-1]
XP_006519646.1. XM_006519583.3. [Q9DAG9-2]
UniGeneiMm.5348.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEQNMR-A232-303[»]
ProteinModelPortaliQ9DAG9.
SMRiQ9DAG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022459.

PTM databases

PhosphoSitePlusiQ9DAG9.

Proteomic databases

PaxDbiQ9DAG9.
PRIDEiQ9DAG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022459; ENSMUSP00000022459; ENSMUSG00000021902. [Q9DAG9-1]
GeneIDi71838.
KEGGimmu:71838.
UCSCiuc007sxf.1. mouse. [Q9DAG9-1]
uc007sxg.1. mouse. [Q9DAG9-2]

Organism-specific databases

CTDi51533.
MGIiMGI:1919088. Phf7.

Phylogenomic databases

eggNOGiKOG1084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00390000005246.
HOGENOMiHOG000236336.
HOVERGENiHBG053588.
InParanoidiQ9DAG9.
OMAiCLYEQGR.
OrthoDBiEOG091G0Q24.
PhylomeDBiQ9DAG9.
TreeFamiTF325426.

Miscellaneous databases

ChiTaRSiPhf7. mouse.
EvolutionaryTraceiQ9DAG9.
PROiQ9DAG9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021902.
CleanExiMM_PHF7.
ExpressionAtlasiQ9DAG9. baseline and differential.
GenevisibleiQ9DAG9. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHF7_MOUSE
AccessioniPrimary (citable) accession number: Q9DAG9
Secondary accession number(s): Q6PG81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.