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Protein

Profilin-3

Gene

Pfn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns4P). Slightly reduces actin polymerization. May be involved in spermatogenesis.By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-3
Alternative name(s):
Profilin III
Gene namesi
Name:Pfn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2178800. Pfn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995801 – 137Profilin-3Add BLAST137

Proteomic databases

PaxDbiQ9DAD6.
PRIDEiQ9DAD6.

PTM databases

PhosphoSitePlusiQ9DAD6.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000044444.
CleanExiMM_PFN3.
GenevisibleiQ9DAD6. MM.

Interactioni

Subunit structurei

Interacts with ACTRT3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Actrt3Q8BXF83EBI-6480328,EBI-6480313

GO - Molecular functioni

  • actin binding Source: MGI

Protein-protein interaction databases

IntActiQ9DAD6. 1 interactor.
MINTiMINT-6741638.
STRINGi10090.ENSMUSP00000054053.

Structurei

3D structure databases

ProteinModelPortaliQ9DAD6.
SMRiQ9DAD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiENOG410IW5Z. Eukaryota.
ENOG410YRK9. LUCA.
GeneTreeiENSGT00390000010143.
HOGENOMiHOG000171592.
HOVERGENiHBG053683.
InParanoidiQ9DAD6.
KOiK05759.
OMAiRRCCVIR.
OrthoDBiEOG091G0TWH.
PhylomeDBiQ9DAD6.
TreeFamiTF331744.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiIPR005455. PFN.
IPR029893. PFN3.
IPR005454. Profilin1/2/3_vertebrate.
[Graphical view]
PANTHERiPTHR13936:SF2. PTHR13936:SF2. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR01639. PROFILINMAML.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DAD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDWKGYISA VLRDQRIDDV AIVGHSDNRC VWASRPGGLL AAISPQEVGV
60 70 80 90 100
LTGPDRHTFL QTGLSVAGRR CCVIRDYLLA EGDGVLDART KGLDGRAICV
110 120 130
GHTPRALLVL MGRRGVHGGI LNKTVHDLIG GLREQCS
Length:137
Mass (Da):14,697
Last modified:June 1, 2001 - v1
Checksum:i939E617834F71BC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF422809 Genomic DNA. Translation: AAL65908.1.
AK005930 mRNA. Translation: BAB24322.1.
BC048629 mRNA. Translation: AAH48629.1.
CCDSiCCDS26545.1.
RefSeqiNP_083579.1. NM_029303.2.
UniGeneiMm.432537.
Mm.473625.

Genome annotation databases

EnsembliENSMUST00000054146; ENSMUSP00000054053; ENSMUSG00000044444.
GeneIDi75477.
KEGGimmu:75477.
UCSCiuc007qqu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF422809 Genomic DNA. Translation: AAL65908.1.
AK005930 mRNA. Translation: BAB24322.1.
BC048629 mRNA. Translation: AAH48629.1.
CCDSiCCDS26545.1.
RefSeqiNP_083579.1. NM_029303.2.
UniGeneiMm.432537.
Mm.473625.

3D structure databases

ProteinModelPortaliQ9DAD6.
SMRiQ9DAD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DAD6. 1 interactor.
MINTiMINT-6741638.
STRINGi10090.ENSMUSP00000054053.

PTM databases

PhosphoSitePlusiQ9DAD6.

Proteomic databases

PaxDbiQ9DAD6.
PRIDEiQ9DAD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054146; ENSMUSP00000054053; ENSMUSG00000044444.
GeneIDi75477.
KEGGimmu:75477.
UCSCiuc007qqu.1. mouse.

Organism-specific databases

CTDi345456.
MGIiMGI:2178800. Pfn3.

Phylogenomic databases

eggNOGiENOG410IW5Z. Eukaryota.
ENOG410YRK9. LUCA.
GeneTreeiENSGT00390000010143.
HOGENOMiHOG000171592.
HOVERGENiHBG053683.
InParanoidiQ9DAD6.
KOiK05759.
OMAiRRCCVIR.
OrthoDBiEOG091G0TWH.
PhylomeDBiQ9DAD6.
TreeFamiTF331744.

Miscellaneous databases

PROiQ9DAD6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044444.
CleanExiMM_PFN3.
GenevisibleiQ9DAD6. MM.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiIPR005455. PFN.
IPR029893. PFN3.
IPR005454. Profilin1/2/3_vertebrate.
[Graphical view]
PANTHERiPTHR13936:SF2. PTHR13936:SF2. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR01639. PROFILINMAML.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPROF3_MOUSE
AccessioniPrimary (citable) accession number: Q9DAD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.