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Q9DAD6

- PROF3_MOUSE

UniProt

Q9DAD6 - PROF3_MOUSE

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Protein
Profilin-3
Gene
Pfn3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton By similarity. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns4P) By similarity. Slightly reduces actin polymerization By similarity. May be involved in spermatogenesis By similarity.

GO - Molecular functioni

  1. ATP:ADP antiporter activity Source: MGI
  2. actin binding Source: MGI
  3. lipid binding Source: UniProtKB-KW
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. ADP transport Source: GOC
  2. ATP transport Source: GOC
  3. actin cytoskeleton organization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-3
Alternative name(s):
Profilin III
Gene namesi
Name:Pfn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:2178800. Pfn3.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Profilin-3
PRO_0000199580Add
BLAST

Proteomic databases

PaxDbiQ9DAD6.
PRIDEiQ9DAD6.

PTM databases

PhosphoSiteiQ9DAD6.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiQ9DAD6.
CleanExiMM_PFN3.
GenevestigatoriQ9DAD6.

Interactioni

Subunit structurei

Interacts with ACTRT3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Actrt3Q8BXF83EBI-6480328,EBI-6480313

Protein-protein interaction databases

IntActiQ9DAD6. 1 interaction.
MINTiMINT-6741638.
STRINGi10090.ENSMUSP00000054053.

Structurei

3D structure databases

ProteinModelPortaliQ9DAD6.
SMRiQ9DAD6. Positions 4-133.

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.

Phylogenomic databases

eggNOGiNOG147630.
GeneTreeiENSGT00390000010143.
HOGENOMiHOG000171592.
HOVERGENiHBG053683.
InParanoidiQ9DAD6.
KOiK05759.
OMAiLDGRAVC.
OrthoDBiEOG7HXCSV.
PhylomeDBiQ9DAD6.
TreeFamiTF331744.

Family and domain databases

InterProiIPR005454. Profilin_chordates.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR01639. PROFILINMAML.
SUPFAMiSSF55770. SSF55770. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DAD6-1 [UniParc]FASTAAdd to Basket

« Hide

MSDWKGYISA VLRDQRIDDV AIVGHSDNRC VWASRPGGLL AAISPQEVGV    50
LTGPDRHTFL QTGLSVAGRR CCVIRDYLLA EGDGVLDART KGLDGRAICV 100
GHTPRALLVL MGRRGVHGGI LNKTVHDLIG GLREQCS 137
Length:137
Mass (Da):14,697
Last modified:June 1, 2001 - v1
Checksum:i939E617834F71BC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF422809 Genomic DNA. Translation: AAL65908.1.
AK005930 mRNA. Translation: BAB24322.1.
BC048629 mRNA. Translation: AAH48629.1.
CCDSiCCDS26545.1.
RefSeqiNP_083579.1. NM_029303.2.
UniGeneiMm.432537.
Mm.473625.

Genome annotation databases

EnsembliENSMUST00000054146; ENSMUSP00000054053; ENSMUSG00000044444.
GeneIDi75477.
KEGGimmu:75477.
UCSCiuc007qqu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF422809 Genomic DNA. Translation: AAL65908.1 .
AK005930 mRNA. Translation: BAB24322.1 .
BC048629 mRNA. Translation: AAH48629.1 .
CCDSi CCDS26545.1.
RefSeqi NP_083579.1. NM_029303.2.
UniGenei Mm.432537.
Mm.473625.

3D structure databases

ProteinModelPortali Q9DAD6.
SMRi Q9DAD6. Positions 4-133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9DAD6. 1 interaction.
MINTi MINT-6741638.
STRINGi 10090.ENSMUSP00000054053.

PTM databases

PhosphoSitei Q9DAD6.

Proteomic databases

PaxDbi Q9DAD6.
PRIDEi Q9DAD6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054146 ; ENSMUSP00000054053 ; ENSMUSG00000044444 .
GeneIDi 75477.
KEGGi mmu:75477.
UCSCi uc007qqu.1. mouse.

Organism-specific databases

CTDi 345456.
MGIi MGI:2178800. Pfn3.

Phylogenomic databases

eggNOGi NOG147630.
GeneTreei ENSGT00390000010143.
HOGENOMi HOG000171592.
HOVERGENi HBG053683.
InParanoidi Q9DAD6.
KOi K05759.
OMAi LDGRAVC.
OrthoDBi EOG7HXCSV.
PhylomeDBi Q9DAD6.
TreeFami TF331744.

Miscellaneous databases

NextBioi 343120.
PROi Q9DAD6.
SOURCEi Search...

Gene expression databases

Bgeei Q9DAD6.
CleanExi MM_PFN3.
Genevestigatori Q9DAD6.

Family and domain databases

InterProi IPR005454. Profilin_chordates.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view ]
Pfami PF00235. Profilin. 1 hit.
[Graphical view ]
PRINTSi PR01639. PROFILINMAML.
SUPFAMi SSF55770. SSF55770. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis."
    Braun A., Aszodi A., Hellebrand H., Berna A., Fassler R., Brandau O.
    Gene 283:219-225(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis."
    Hara Y., Yamagata K., Oguchi K., Baba T.
    FEBS Lett. 582:2998-3004(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ACTRT3.

Entry informationi

Entry nameiPROF3_MOUSE
AccessioniPrimary (citable) accession number: Q9DAD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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