Q9DAD6 (PROF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Profilin-3

Alternative name(s):
Profilin III

Gene names

Name:

Pfn3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton By similarity. May be involved in spermatogenesis.
Subunit structure	Interacts with ACTRT3. Ref.4
Subcellular location	Cytoplasm › cytoskeleton By similarity. Nucleus Ref.4.
Tissue specificity	Testis specific. Ref.1
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Nucleus
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP:ADP antiporter activity Traceable author statement Ref.1. Source: MGI actin binding Traceable author statement Ref.1. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Actrt3	Q8BXF8	3	EBI-6480328,EBI-6480313

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 137	137	Profilin-3		PRO_0000199580

Sequences

	Sequence		Length	Mass (Da)
	Q9DAD6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 939E617834F71BC8	FASTA	137	14,697
	10 20 30 40 50 60 MSDWKGYISA VLRDQRIDDV AIVGHSDNRC VWASRPGGLL AAISPQEVGV LTGPDRHTFL 70 80 90 100 110 120 QTGLSVAGRR CCVIRDYLLA EGDGVLDART KGLDGRAICV GHTPRALLVL MGRRGVHGGI 130 LNKTVHDLIG GLREQCS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis." Braun A., Aszodi A., Hellebrand H., Berna A., Fassler R., Brandau O. Gene 283:219-225(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY. Strain: 129/Sv.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis." Hara Y., Yamagata K., Oguchi K., Baba T. FEBS Lett. 582:2998-3004(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ACTRT3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF422809 Genomic DNA. Translation: AAL65908.1. AK005930 mRNA. Translation: BAB24322.1. BC048629 mRNA. Translation: AAH48629.1.
IPI	IPI00118497.
RefSeq	NP_083579.1. NM_029303.2.
UniGene	Mm.432537. Mm.473625.
3D structure databases
ProteinModelPortal	Q9DAD6.
SMR	Q9DAD6. Positions 4-133.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9DAD6. 1 interaction.
MINT	MINT-6741638.
STRING	10090.ENSMUSP00000054053.
PTM databases
PhosphoSite	Q9DAD6.
Proteomic databases
PaxDb	Q9DAD6.
PRIDE	Q9DAD6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000054146; ENSMUSP00000054053; ENSMUSG00000044444.
GeneID	75477.
KEGG	mmu:75477.
UCSC	uc007qqu.1. mouse.
Organism-specific databases
CTD	345456.
MGI	MGI:2178800. Pfn3.
Phylogenomic databases
eggNOG	NOG147630.
GeneTree	ENSGT00390000010143.
HOGENOM	HOG000171592.
HOVERGEN	HBG053683.
InParanoid	Q9DAD6.
KO	K05759.
OMA	RRCCVIR.
OrthoDB	EOG4SN1Q1.
Gene expression databases
Bgee	Q9DAD6.
CleanEx	MM_PFN3.
Genevestigator	Q9DAD6.
GermOnline	ENSMUSG00000044444. Mus musculus.
Family and domain databases
InterPro	IPR005454. Profilin_chordates. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR01639. PROFILINMAML.
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	343120.
SOURCE	Search...

Entry information

Entry name

PROF3_MOUSE

Accession

Primary (citable) accession number: Q9DAD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program