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Q9DAD6

- PROF3_MOUSE

UniProt

Q9DAD6 - PROF3_MOUSE

Protein

Profilin-3

Gene

Pfn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns4P). Slightly reduces actin polymerization. May be involved in spermatogenesis.By similarity

    GO - Molecular functioni

    1. actin binding Source: MGI
    2. ATP:ADP antiporter activity Source: MGI
    3. lipid binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro
    2. ADP transport Source: GOC
    3. ATP transport Source: GOC

    Keywords - Ligandi

    Actin-binding, Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Profilin-3
    Alternative name(s):
    Profilin III
    Gene namesi
    Name:Pfn3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:2178800. Pfn3.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 137137Profilin-3PRO_0000199580Add
    BLAST

    Proteomic databases

    PaxDbiQ9DAD6.
    PRIDEiQ9DAD6.

    PTM databases

    PhosphoSiteiQ9DAD6.

    Expressioni

    Tissue specificityi

    Testis specific.1 Publication

    Gene expression databases

    BgeeiQ9DAD6.
    CleanExiMM_PFN3.
    GenevestigatoriQ9DAD6.

    Interactioni

    Subunit structurei

    Interacts with ACTRT3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Actrt3Q8BXF83EBI-6480328,EBI-6480313

    Protein-protein interaction databases

    IntActiQ9DAD6. 1 interaction.
    MINTiMINT-6741638.
    STRINGi10090.ENSMUSP00000054053.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DAD6.
    SMRiQ9DAD6. Positions 4-133.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the profilin family.Curated

    Phylogenomic databases

    eggNOGiNOG147630.
    GeneTreeiENSGT00390000010143.
    HOGENOMiHOG000171592.
    HOVERGENiHBG053683.
    InParanoidiQ9DAD6.
    KOiK05759.
    OMAiLDGRAVC.
    OrthoDBiEOG7HXCSV.
    PhylomeDBiQ9DAD6.
    TreeFamiTF331744.

    Family and domain databases

    InterProiIPR005454. Profilin_chordates.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view]
    PfamiPF00235. Profilin. 1 hit.
    [Graphical view]
    PRINTSiPR01639. PROFILINMAML.
    SUPFAMiSSF55770. SSF55770. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9DAD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDWKGYISA VLRDQRIDDV AIVGHSDNRC VWASRPGGLL AAISPQEVGV    50
    LTGPDRHTFL QTGLSVAGRR CCVIRDYLLA EGDGVLDART KGLDGRAICV 100
    GHTPRALLVL MGRRGVHGGI LNKTVHDLIG GLREQCS 137
    Length:137
    Mass (Da):14,697
    Last modified:June 1, 2001 - v1
    Checksum:i939E617834F71BC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF422809 Genomic DNA. Translation: AAL65908.1.
    AK005930 mRNA. Translation: BAB24322.1.
    BC048629 mRNA. Translation: AAH48629.1.
    CCDSiCCDS26545.1.
    RefSeqiNP_083579.1. NM_029303.2.
    UniGeneiMm.432537.
    Mm.473625.

    Genome annotation databases

    EnsembliENSMUST00000054146; ENSMUSP00000054053; ENSMUSG00000044444.
    GeneIDi75477.
    KEGGimmu:75477.
    UCSCiuc007qqu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF422809 Genomic DNA. Translation: AAL65908.1 .
    AK005930 mRNA. Translation: BAB24322.1 .
    BC048629 mRNA. Translation: AAH48629.1 .
    CCDSi CCDS26545.1.
    RefSeqi NP_083579.1. NM_029303.2.
    UniGenei Mm.432537.
    Mm.473625.

    3D structure databases

    ProteinModelPortali Q9DAD6.
    SMRi Q9DAD6. Positions 4-133.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9DAD6. 1 interaction.
    MINTi MINT-6741638.
    STRINGi 10090.ENSMUSP00000054053.

    PTM databases

    PhosphoSitei Q9DAD6.

    Proteomic databases

    PaxDbi Q9DAD6.
    PRIDEi Q9DAD6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054146 ; ENSMUSP00000054053 ; ENSMUSG00000044444 .
    GeneIDi 75477.
    KEGGi mmu:75477.
    UCSCi uc007qqu.1. mouse.

    Organism-specific databases

    CTDi 345456.
    MGIi MGI:2178800. Pfn3.

    Phylogenomic databases

    eggNOGi NOG147630.
    GeneTreei ENSGT00390000010143.
    HOGENOMi HOG000171592.
    HOVERGENi HBG053683.
    InParanoidi Q9DAD6.
    KOi K05759.
    OMAi LDGRAVC.
    OrthoDBi EOG7HXCSV.
    PhylomeDBi Q9DAD6.
    TreeFami TF331744.

    Miscellaneous databases

    NextBioi 343120.
    PROi Q9DAD6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DAD6.
    CleanExi MM_PFN3.
    Genevestigatori Q9DAD6.

    Family and domain databases

    InterProi IPR005454. Profilin_chordates.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view ]
    Pfami PF00235. Profilin. 1 hit.
    [Graphical view ]
    PRINTSi PR01639. PROFILINMAML.
    SUPFAMi SSF55770. SSF55770. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis."
      Braun A., Aszodi A., Hellebrand H., Berna A., Fassler R., Brandau O.
      Gene 283:219-225(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129/Sv.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis."
      Hara Y., Yamagata K., Oguchi K., Baba T.
      FEBS Lett. 582:2998-3004(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ACTRT3.

    Entry informationi

    Entry nameiPROF3_MOUSE
    AccessioniPrimary (citable) accession number: Q9DAD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3