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Q9DAD6 (PROF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Profilin-3
Alternative name(s):
Profilin III
Gene names
Name:Pfn3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to actin and affects the structure of the cytoskeleton By similarity. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns4P) By similarity. Slightly reduces actin polymerization By similarity. May be involved in spermatogenesis By similarity.

Subunit structure

Interacts with ACTRT3. Ref.4

Subcellular location

Cytoplasmcytoskeleton By similarity. Nucleus Ref.4.

Tissue specificity

Testis specific. Ref.1

Sequence similarities

Belongs to the profilin family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Actrt3Q8BXF83EBI-6480328,EBI-6480313

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 137137Profilin-3
PRO_0000199580

Sequences

Sequence LengthMass (Da)Tools
Q9DAD6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 939E617834F71BC8

FASTA13714,697
        10         20         30         40         50         60 
MSDWKGYISA VLRDQRIDDV AIVGHSDNRC VWASRPGGLL AAISPQEVGV LTGPDRHTFL 

        70         80         90        100        110        120 
QTGLSVAGRR CCVIRDYLLA EGDGVLDART KGLDGRAICV GHTPRALLVL MGRRGVHGGI 

       130 
LNKTVHDLIG GLREQCS 

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis."
Braun A., Aszodi A., Hellebrand H., Berna A., Fassler R., Brandau O.
Gene 283:219-225(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: 129/Sv.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis."
Hara Y., Yamagata K., Oguchi K., Baba T.
FEBS Lett. 582:2998-3004(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ACTRT3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF422809 Genomic DNA. Translation: AAL65908.1.
AK005930 mRNA. Translation: BAB24322.1.
BC048629 mRNA. Translation: AAH48629.1.
RefSeqNP_083579.1. NM_029303.2.
UniGeneMm.432537.
Mm.473625.

3D structure databases

ProteinModelPortalQ9DAD6.
SMRQ9DAD6. Positions 4-133.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9DAD6. 1 interaction.
MINTMINT-6741638.
STRING10090.ENSMUSP00000054053.

PTM databases

PhosphoSiteQ9DAD6.

Proteomic databases

PaxDbQ9DAD6.
PRIDEQ9DAD6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054146; ENSMUSP00000054053; ENSMUSG00000044444.
GeneID75477.
KEGGmmu:75477.
UCSCuc007qqu.1. mouse.

Organism-specific databases

CTD345456.
MGIMGI:2178800. Pfn3.

Phylogenomic databases

eggNOGNOG147630.
GeneTreeENSGT00390000010143.
HOGENOMHOG000171592.
HOVERGENHBG053683.
InParanoidQ9DAD6.
KOK05759.
OMARRCCVIR.
OrthoDBEOG7HXCSV.
PhylomeDBQ9DAD6.
TreeFamTF331744.

Gene expression databases

BgeeQ9DAD6.
CleanExMM_PFN3.
GenevestigatorQ9DAD6.

Family and domain databases

InterProIPR005454. Profilin_chordates.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PfamPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSPR01639. PROFILINMAML.
SUPFAMSSF55770. SSF55770. 1 hit.
ProtoNetSearch...

Other

NextBio343120.
PROQ9DAD6.
SOURCESearch...

Entry information

Entry namePROF3_MOUSE
AccessionPrimary (citable) accession number: Q9DAD6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot