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Q9DAC9

- PO5F2_MOUSE

UniProt

Q9DAC9 - PO5F2_MOUSE

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Protein

POU domain, class 5, transcription factor 2

Gene

Pou5f2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi199 – 25860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 5, transcription factor 2
Alternative name(s):
Sperm 1 POU domain transcription factor
Short name:
SPRM-1
Gene namesi
Name:Pou5f2
Synonyms:Sprm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1922757. Pou5f2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329POU domain, class 5, transcription factor 2PRO_0000100757Add
BLAST

Proteomic databases

PRIDEiQ9DAC9.

Expressioni

Tissue specificityi

In adult brain, expressed in the olfactory bulb, becoming specifically concentrated in the mitral cell layer. Also found in the pyramidal cell layer of the hippocampus, in the granule cell layer of the cerebellum and in the cortex.1 Publication

Developmental stagei

Low expression levels observed at 12 dpc in neural tube and brain. On days 15.5 and 16.5, expression levels increased and became localized specifically to the forebrain, with highest levels found in the laminar region of the forebrain cortex. Also expressed in the mitral region of the olfactory bulb.1 Publication

Gene expression databases

BgeeiQ9DAC9.
GenevestigatoriQ9DAC9.

Structurei

3D structure databases

ProteinModelPortaliQ9DAC9.
SMRiQ9DAC9. Positions 107-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 18175POU-specificPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00760000118935.
HOVERGENiHBG057998.
InParanoidiQ9DAC9.
OrthoDBiEOG7MKW6H.
PhylomeDBiQ9DAC9.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGRRSSNVF PLSGNSGGGL EVDTPTWLSS QAATSRLMVR PSMGPGICPG
60 70 80 90 100
PEVWGVPLGS SPYEFRGGIA PYRACEARAW SQSSSEDTCP GPYIALRYMP
110 120 130 140 150
NLALPEDVSA IQKEMEQLAK ELRQKRMTLG YSQADVGFAV GAMFGKVLSQ
160 170 180 190 200
TTICRFEAQQ LSLANMWKLR PLLKMWLEEV DEKNLLGICR MEMILEQARK
210 220 230 240 250
RRRASRERRI GSNLEKLFLQ CPEPTPQQIS YIAGRLRLQK DLVQVWFSNR
260 270 280 290 300
SQMGSWPTND TSRREDVGAT GSPFPGPPVC FPMAPGLHFD FTHYEGSCLT
310 320
PLYSSTPFPV RGALLSAPTT TLGLPRLSS
Length:329
Mass (Da):36,411
Last modified:June 1, 2001 - v1
Checksum:iA882639979987F31
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti292 – 2921T → P in BAC36466. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005948 mRNA. Translation: BAB24332.1.
AK076753 mRNA. Translation: BAC36466.1.
CCDSiCCDS56895.1.
RefSeqiNP_083591.1. NM_029315.1.
UniGeneiMm.443255.

Genome annotation databases

EnsembliENSMUST00000175955; ENSMUSP00000135597; ENSMUSG00000093668.
GeneIDi75507.
KEGGimmu:75507.
UCSCiuc011zcd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005948 mRNA. Translation: BAB24332.1 .
AK076753 mRNA. Translation: BAC36466.1 .
CCDSi CCDS56895.1.
RefSeqi NP_083591.1. NM_029315.1.
UniGenei Mm.443255.

3D structure databases

ProteinModelPortali Q9DAC9.
SMRi Q9DAC9. Positions 107-254.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9DAC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000175955 ; ENSMUSP00000135597 ; ENSMUSG00000093668 .
GeneIDi 75507.
KEGGi mmu:75507.
UCSCi uc011zcd.1. mouse.

Organism-specific databases

CTDi 134187.
MGIi MGI:1922757. Pou5f2.

Phylogenomic databases

GeneTreei ENSGT00760000118935.
HOVERGENi HBG057998.
InParanoidi Q9DAC9.
OrthoDBi EOG7MKW6H.
PhylomeDBi Q9DAC9.
TreeFami TF316413.

Miscellaneous databases

NextBioi 343200.
PROi Q9DAC9.
SOURCEi Search...

Gene expression databases

Bgeei Q9DAC9.
Genevestigatori Q9DAC9.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
    Wey E., Lyons G.E., Schaefer B.W.
    Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPO5F2_MOUSE
AccessioniPrimary (citable) accession number: Q9DAC9
Secondary accession number(s): Q8BVS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3