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Protein

Septin-14

Gene

Sept14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei113 – 1131GTP; via amide nitrogenBy similarity
Binding sitei246 – 2461GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei261 – 2611GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi58 – 658GTPBy similarity
Nucleotide bindingi194 – 2029GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-14
Gene namesi
Name:Sept14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1921472. Sept14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Septin-14PRO_0000294426Add
BLAST

Proteomic databases

EPDiQ9DA97.
MaxQBiQ9DA97.
PaxDbiQ9DA97.
PeptideAtlasiQ9DA97.
PRIDEiQ9DA97.

PTM databases

iPTMnetiQ9DA97.
PhosphoSiteiQ9DA97.

Expressioni

Gene expression databases

BgeeiQ9DA97.
CleanExiMM_SEPT14.
ExpressionAtlasiQ9DA97. baseline and differential.
GenevisibleiQ9DA97. MM.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044272.

Structurei

3D structure databases

ProteinModelPortaliQ9DA97.
SMRiQ9DA97. Positions 50-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 313266Septin-type GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili329 – 41082Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ9DA97.
KOiK16941.
OMAiNIRCLTT.
OrthoDBiEOG7J9VQK.
TreeFamiTF101080.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DA97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPTNTSV PIPGSEDPQK ENIRCLSTLG HFGFECLPTQ LVNKSIQKGF
60 70 80 90 100
SFNILCVGET GIGKTTLINT LFNTNLKETK SSHFYSKVGL TVKTYELLER
110 120 130 140 150
NIPLRLTVVK TVGYGDQINK EASYQPVVDY LDAQFEAYLQ EELKIKRSLA
160 170 180 190 200
DYHDSRIHVC LYFITPTGHS LKSLDLLTMK SIDRRVNIIP LIAKADSLSK
210 220 230 240 250
NDLQRFKNNI MSELNSNGIQ IYQFQVDDEA SAQVNSSGLL PFAVVGSMEE
260 270 280 290 300
VKVGKRMVRG RHYPWGVLQE VENENHCDFV KLRDLLLSTN MEDLKDQTHT
310 320 330 340 350
QHYECYRSNR LQKLGFSDTG PDNRPVSFQE MYEAKRREFH NQCQKEEEEL
360 370 380 390 400
KQTFMQRVKE KELTFKDAEK ELQDKFEHLK RIQQEEILKL EEERRKLEEQ
410 420 430
IIDFYKMKAA SESAQAQVCT NIKKDKDRKK
Length:430
Mass (Da):49,811
Last modified:April 3, 2013 - v3
Checksum:i769580BADF745878
GO

Sequence cautioni

The sequence BAB24381.1 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti270 – 2701Missing in BAB24381 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120413 Genomic DNA. No translation available.
AK006043 mRNA. Translation: BAB24381.1. Sequence problems.
RefSeqiNP_083102.1. NM_028826.1.
XP_006504389.1. XM_006504326.2.
UniGeneiMm.159143.

Genome annotation databases

EnsembliENSMUST00000042266; ENSMUSP00000044272; ENSMUSG00000034219.
GeneIDi74222.
KEGGimmu:74222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120413 Genomic DNA. No translation available.
AK006043 mRNA. Translation: BAB24381.1. Sequence problems.
RefSeqiNP_083102.1. NM_028826.1.
XP_006504389.1. XM_006504326.2.
UniGeneiMm.159143.

3D structure databases

ProteinModelPortaliQ9DA97.
SMRiQ9DA97. Positions 50-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044272.

PTM databases

iPTMnetiQ9DA97.
PhosphoSiteiQ9DA97.

Proteomic databases

EPDiQ9DA97.
MaxQBiQ9DA97.
PaxDbiQ9DA97.
PeptideAtlasiQ9DA97.
PRIDEiQ9DA97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042266; ENSMUSP00000044272; ENSMUSG00000034219.
GeneIDi74222.
KEGGimmu:74222.

Organism-specific databases

CTDi346288.
MGIiMGI:1921472. Sept14.

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ9DA97.
KOiK16941.
OMAiNIRCLTT.
OrthoDBiEOG7J9VQK.
TreeFamiTF101080.

Miscellaneous databases

PROiQ9DA97.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DA97.
CleanExiMM_SEPT14.
ExpressionAtlasiQ9DA97. baseline and differential.
GenevisibleiQ9DA97. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-430.
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiSEP14_MOUSE
AccessioniPrimary (citable) accession number: Q9DA97
Secondary accession number(s): E9QMM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 3, 2013
Last modified: July 6, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.