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Q9DA79

- DPEP3_MOUSE

UniProt

Q9DA79 - DPEP3_MOUSE

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Protein

Dipeptidase 3

Gene

Dpep3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis.1 Publication

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zinc.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.1 Publication

Kineticsi

  1. KM=2.5 mM for cystinyl-bis-glycine1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi96 – 961Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi193 – 1931Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi193 – 1931Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi266 – 2661Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi287 – 2871Zinc 2; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro
  5. peptidase activity Source: MGI

GO - Biological processi

  1. male meiosis Source: UniProtKB
  2. proteolysis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Meiosis

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 3 (EC:3.4.13.19)
Alternative name(s):
Membrane-bound dipeptidase 3
Short name:
MBD-3
Protein expressed in male leptotene and zygotene spermatocytes 136
Short name:
MLZ-136
Gene namesi
Name:Dpep3
Synonyms:Mbd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1919104. Dpep3.

Subcellular locationi

Membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 462427Dipeptidase 3PRO_0000231613Add
BLAST
Propeptidei463 – 49331Removed in mature formSequence AnalysisPRO_0000231614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi143 ↔ 222PROSITE-ProRule annotation
Disulfide bondi294 ↔ 326PROSITE-ProRule annotation
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi431 – 431InterchainPROSITE-ProRule annotation
Lipidationi462 – 4621GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9DA79.
PRIDEiQ9DA79.

PTM databases

PhosphoSiteiQ9DA79.

Expressioni

Tissue specificityi

Expressed in testis but not ovary.2 Publications

Developmental stagei

expressed in ovary and testis at E15.5.1 Publication

Gene expression databases

BgeeiQ9DA79.
CleanExiMM_DPEP3.
MM_MBD3.
GenevestigatoriQ9DA79.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Protein-protein interaction databases

IntActiQ9DA79. 1 interaction.
MINTiMINT-8174108.

Structurei

3D structure databases

ProteinModelPortaliQ9DA79.
SMRiQ9DA79. Positions 77-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2355.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ9DA79.
OMAiAPVFDGH.
OrthoDBiEOG7SJD4N.
PhylomeDBiQ9DA79.
TreeFamiTF324523.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DA79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPAGLEGPR ALGLRPLGHR LSLLGVLLLV PSLWVTCTLT TPSPSSAPTT
60 70 80 90 100
PEASNATTAP GIPNDTATSG VTSDPRLREQ ALALMRDFPL VDGHNDLPLL
110 120 130 140 150
LRELFQNQLQ DVNLRNFTRG QTNLDRLRDG LVGAQFWSAY IPCQTQDRDA
160 170 180 190 200
VRLALEQIDL IRRMCSAYPE LELVTSADGL NNTQKLACLI GVEGGHSLDT
210 220 230 240 250
SLAVLRSFYE LGVRYLTLTF TCSTPWAESA TKFRHHFYTN ISGLTSFGEK
260 270 280 290 300
VVEEMNRLGM MIDLSHASDT LVKQTLEVSQ APVIFSHSAA RSVCDNLLNI
310 320 330 340 350
PDDILQLLKK NGGIVMVTLS MGVLQCSLFA NVSTVADHFD HIRTVIGSEF
360 370 380 390 400
IGIGGSYDGS GRFPQGLEDV STYPVLIEEL LSRGWDEREL QGVLRGNLLR
410 420 430 440 450
VFRQVEQVRE KSLGQSPVEV KFPERQQSNT CHSHLLPQPQ EDQHQDTHLK
460 470 480 490
VTKLPNILQR ASKAPPHPLP GLMATLTSLA LILWLCCSGH RAV
Length:493
Mass (Da):54,247
Last modified:June 1, 2001 - v1
Checksum:iB9A0D39BB7CEB619
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF488553 mRNA. Translation: AAP84987.1.
AK006085 mRNA. Translation: BAB24402.1.
BC051148 mRNA. Translation: AAH51148.1.
CCDSiCCDS22624.1.
RefSeqiNP_082236.1. NM_027960.2.
UniGeneiMm.173395.

Genome annotation databases

EnsembliENSMUST00000034371; ENSMUSP00000034371; ENSMUSG00000031898.
GeneIDi71854.
KEGGimmu:71854.
UCSCiuc009net.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF488553 mRNA. Translation: AAP84987.1 .
AK006085 mRNA. Translation: BAB24402.1 .
BC051148 mRNA. Translation: AAH51148.1 .
CCDSi CCDS22624.1.
RefSeqi NP_082236.1. NM_027960.2.
UniGenei Mm.173395.

3D structure databases

ProteinModelPortali Q9DA79.
SMRi Q9DA79. Positions 77-434.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9DA79. 1 interaction.
MINTi MINT-8174108.

Protein family/group databases

MEROPSi M19.011.

PTM databases

PhosphoSitei Q9DA79.

Proteomic databases

PaxDbi Q9DA79.
PRIDEi Q9DA79.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034371 ; ENSMUSP00000034371 ; ENSMUSG00000031898 .
GeneIDi 71854.
KEGGi mmu:71854.
UCSCi uc009net.1. mouse.

Organism-specific databases

CTDi 64180.
MGIi MGI:1919104. Dpep3.

Phylogenomic databases

eggNOGi COG2355.
GeneTreei ENSGT00390000017920.
HOGENOMi HOG000072016.
HOVERGENi HBG002339.
InParanoidi Q9DA79.
OMAi APVFDGH.
OrthoDBi EOG7SJD4N.
PhylomeDBi Q9DA79.
TreeFami TF324523.

Miscellaneous databases

NextBioi 334738.
PROi Q9DA79.
SOURCEi Search...

Gene expression databases

Bgeei Q9DA79.
CleanExi MM_DPEP3.
MM_MBD3.
Genevestigatori Q9DA79.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two additional members of the membrane-bound dipeptidase family."
    Habib G.M., Shi Z.-Z., Cuevas A.A., Lieberman M.W.
    FASEB J. 17:1313-1315(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION.
    Strain: L129.
    Tissue: Spleen and Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans."
    Kogo H., Kowa-Sugiyama H., Yamada K., Bolor H., Tsutsumi M., Ohye T., Inagaki H., Taniguchi M., Toda T., Kurahashi H.
    J. Hum. Genet. 55:293-299(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiDPEP3_MOUSE
AccessioniPrimary (citable) accession number: Q9DA79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3