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Q9DA79

- DPEP3_MOUSE

UniProt

Q9DA79 - DPEP3_MOUSE

Protein

Dipeptidase 3

Gene

Dpep3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis.1 Publication

    Catalytic activityi

    Hydrolysis of dipeptides.PROSITE-ProRule annotation

    Cofactori

    Zinc.PROSITE-ProRule annotation

    Enzyme regulationi

    Inhibited by L-penicillamine.1 Publication

    Kineticsi

    1. KM=2.5 mM for cystinyl-bis-glycine1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi94 – 941Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi96 – 961Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi193 – 1931Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi193 – 1931Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi266 – 2661Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi287 – 2871Zinc 2; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-KW
    2. dipeptidyl-peptidase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. metalloexopeptidase activity Source: InterPro
    5. peptidase activity Source: MGI
    6. protein binding Source: MGI

    GO - Biological processi

    1. male meiosis Source: UniProtKB
    2. proteolysis Source: MGI

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Meiosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM19.011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidase 3 (EC:3.4.13.19)
    Alternative name(s):
    Membrane-bound dipeptidase 3
    Short name:
    MBD-3
    Protein expressed in male leptotene and zygotene spermatocytes 136
    Short name:
    MLZ-136
    Gene namesi
    Name:Dpep3
    Synonyms:Mbd3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1919104. Dpep3.

    Subcellular locationi

    Membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 462427Dipeptidase 3PRO_0000231613Add
    BLAST
    Propeptidei463 – 49331Removed in mature formSequence AnalysisPRO_0000231614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi143 ↔ 222PROSITE-ProRule annotation
    Disulfide bondi294 ↔ 326PROSITE-ProRule annotation
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi431 – 431InterchainPROSITE-ProRule annotation
    Lipidationi462 – 4621GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ9DA79.
    PRIDEiQ9DA79.

    PTM databases

    PhosphoSiteiQ9DA79.

    Expressioni

    Tissue specificityi

    Expressed in testis but not ovary.2 Publications

    Developmental stagei

    expressed in ovary and testis at E15.5.1 Publication

    Gene expression databases

    BgeeiQ9DA79.
    CleanExiMM_DPEP3.
    MM_MBD3.
    GenevestigatoriQ9DA79.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.PROSITE-ProRule annotation

    Protein-protein interaction databases

    IntActiQ9DA79. 1 interaction.
    MINTiMINT-8174108.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DA79.
    SMRiQ9DA79. Positions 77-434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2355.
    GeneTreeiENSGT00390000017920.
    HOGENOMiHOG000072016.
    HOVERGENiHBG002339.
    InParanoidiQ9DA79.
    OMAiAPVFDGH.
    OrthoDBiEOG7SJD4N.
    PhylomeDBiQ9DA79.
    TreeFamiTF324523.

    Family and domain databases

    InterProiIPR000180. Dipep_AS.
    IPR028533. Dpep3.
    IPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF14. PTHR10443:SF14. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DA79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPAGLEGPR ALGLRPLGHR LSLLGVLLLV PSLWVTCTLT TPSPSSAPTT    50
    PEASNATTAP GIPNDTATSG VTSDPRLREQ ALALMRDFPL VDGHNDLPLL 100
    LRELFQNQLQ DVNLRNFTRG QTNLDRLRDG LVGAQFWSAY IPCQTQDRDA 150
    VRLALEQIDL IRRMCSAYPE LELVTSADGL NNTQKLACLI GVEGGHSLDT 200
    SLAVLRSFYE LGVRYLTLTF TCSTPWAESA TKFRHHFYTN ISGLTSFGEK 250
    VVEEMNRLGM MIDLSHASDT LVKQTLEVSQ APVIFSHSAA RSVCDNLLNI 300
    PDDILQLLKK NGGIVMVTLS MGVLQCSLFA NVSTVADHFD HIRTVIGSEF 350
    IGIGGSYDGS GRFPQGLEDV STYPVLIEEL LSRGWDEREL QGVLRGNLLR 400
    VFRQVEQVRE KSLGQSPVEV KFPERQQSNT CHSHLLPQPQ EDQHQDTHLK 450
    VTKLPNILQR ASKAPPHPLP GLMATLTSLA LILWLCCSGH RAV 493
    Length:493
    Mass (Da):54,247
    Last modified:June 1, 2001 - v1
    Checksum:iB9A0D39BB7CEB619
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF488553 mRNA. Translation: AAP84987.1.
    AK006085 mRNA. Translation: BAB24402.1.
    BC051148 mRNA. Translation: AAH51148.1.
    CCDSiCCDS22624.1.
    RefSeqiNP_082236.1. NM_027960.2.
    UniGeneiMm.173395.

    Genome annotation databases

    EnsembliENSMUST00000034371; ENSMUSP00000034371; ENSMUSG00000031898.
    GeneIDi71854.
    KEGGimmu:71854.
    UCSCiuc009net.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF488553 mRNA. Translation: AAP84987.1 .
    AK006085 mRNA. Translation: BAB24402.1 .
    BC051148 mRNA. Translation: AAH51148.1 .
    CCDSi CCDS22624.1.
    RefSeqi NP_082236.1. NM_027960.2.
    UniGenei Mm.173395.

    3D structure databases

    ProteinModelPortali Q9DA79.
    SMRi Q9DA79. Positions 77-434.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9DA79. 1 interaction.
    MINTi MINT-8174108.

    Protein family/group databases

    MEROPSi M19.011.

    PTM databases

    PhosphoSitei Q9DA79.

    Proteomic databases

    PaxDbi Q9DA79.
    PRIDEi Q9DA79.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034371 ; ENSMUSP00000034371 ; ENSMUSG00000031898 .
    GeneIDi 71854.
    KEGGi mmu:71854.
    UCSCi uc009net.1. mouse.

    Organism-specific databases

    CTDi 64180.
    MGIi MGI:1919104. Dpep3.

    Phylogenomic databases

    eggNOGi COG2355.
    GeneTreei ENSGT00390000017920.
    HOGENOMi HOG000072016.
    HOVERGENi HBG002339.
    InParanoidi Q9DA79.
    OMAi APVFDGH.
    OrthoDBi EOG7SJD4N.
    PhylomeDBi Q9DA79.
    TreeFami TF324523.

    Miscellaneous databases

    NextBioi 334738.
    PROi Q9DA79.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DA79.
    CleanExi MM_DPEP3.
    MM_MBD3.
    Genevestigatori Q9DA79.

    Family and domain databases

    InterProi IPR000180. Dipep_AS.
    IPR028533. Dpep3.
    IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF14. PTHR10443:SF14. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two additional members of the membrane-bound dipeptidase family."
      Habib G.M., Shi Z.-Z., Cuevas A.A., Lieberman M.W.
      FASEB J. 17:1313-1315(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION.
      Strain: L129.
      Tissue: Spleen and Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans."
      Kogo H., Kowa-Sugiyama H., Yamada K., Bolor H., Tsutsumi M., Ohye T., Inagaki H., Taniguchi M., Toda T., Kurahashi H.
      J. Hum. Genet. 55:293-299(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiDPEP3_MOUSE
    AccessioniPrimary (citable) accession number: Q9DA79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3