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Protein

Intraflagellar transport protein 43 homolog

Gene

Ift43

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 43 homolog
Gene namesi
Name:Ift43
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1923661. Ift43.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projectioncilium 1 Publication

  • Note: Associated with microtubules.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Intraflagellar transport protein 43 homologPRO_0000254042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9DA69.
PRIDEiQ9DA69.

PTM databases

PhosphoSiteiQ9DA69.

Expressioni

Gene expression databases

BgeeiENSMUSG00000007867.
CleanExiMM_1700019E19RIK.
GenevisibleiQ9DA69. MM.

Interactioni

Subunit structurei

Component of the IFT complex A (IFT-A) complex. Interacts with WDR35/IFT121 (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the IFT43 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012060.
HOVERGENiHBG081288.
InParanoidiQ9DA69.
KOiK19675.
OMAiQSEREDH.
OrthoDBiEOG091G12FE.
PhylomeDBiQ9DA69.
TreeFamiTF323566.

Family and domain databases

InterProiIPR029302. IFT43.
[Graphical view]
PfamiPF15305. IFT43. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DA69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDLLDLGEE RRRSSATSGA KMGRRAHQES TQAENYLNSK NSSLTQTGEA
60 70 80 90 100
PPPKPPRRQG GWADDSMKMA KLGKKVSEEM EDHRLRQQNL MGSDDDDIPV
110 120 130 140 150
IPDLEDVQEE DFVLQVASPP SIQVNRVMTY RDLDNDLMKY SAFQTLDGEI
160 170 180 190 200
DLKLLTKVLA PEHEVREDDV GWDWDHLYTE VSSELLTEWD LLRAEKEDPV

GPSRYI
Length:206
Mass (Da):23,501
Last modified:October 31, 2006 - v2
Checksum:i318C95F1D108B9FE
GO
Isoform 2 (identifier: Q9DA69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-82: KLGKKVSEEMED → N

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):22,241
Checksum:i13F28081FFF6AD5A
GO
Isoform 3 (identifier: Q9DA69-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MDDLLDLGEERRRSSATS → MLGAG

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):21,897
Checksum:i090C8BA23BAF3511
GO

Sequence cautioni

The sequence AAH38915 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818MDDLL…SSATS → MLGAG in isoform 3. 1 PublicationVSP_021170Add
BLAST
Alternative sequencei71 – 8212KLGKK…EEMED → N in isoform 2. 1 PublicationVSP_021171Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006115 mRNA. Translation: BAB24415.1.
BC034668 mRNA. Translation: AAH34668.1.
BC038915 mRNA. Translation: AAH38915.1. Different initiation.
CCDSiCCDS26064.1. [Q9DA69-2]
RefSeqiNP_001186772.1. NM_001199843.1. [Q9DA69-1]
NP_083877.1. NM_029601.3. [Q9DA69-2]
UniGeneiMm.292345.

Genome annotation databases

EnsembliENSMUST00000054565; ENSMUSP00000061891; ENSMUSG00000007867. [Q9DA69-2]
GeneIDi76411.
KEGGimmu:76411.
UCSCiuc007oho.2. mouse. [Q9DA69-2]
uc007ohp.2. mouse. [Q9DA69-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006115 mRNA. Translation: BAB24415.1.
BC034668 mRNA. Translation: AAH34668.1.
BC038915 mRNA. Translation: AAH38915.1. Different initiation.
CCDSiCCDS26064.1. [Q9DA69-2]
RefSeqiNP_001186772.1. NM_001199843.1. [Q9DA69-1]
NP_083877.1. NM_029601.3. [Q9DA69-2]
UniGeneiMm.292345.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9DA69.

Proteomic databases

MaxQBiQ9DA69.
PRIDEiQ9DA69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054565; ENSMUSP00000061891; ENSMUSG00000007867. [Q9DA69-2]
GeneIDi76411.
KEGGimmu:76411.
UCSCiuc007oho.2. mouse. [Q9DA69-2]
uc007ohp.2. mouse. [Q9DA69-1]

Organism-specific databases

CTDi112752.
MGIiMGI:1923661. Ift43.

Phylogenomic databases

GeneTreeiENSGT00390000012060.
HOVERGENiHBG081288.
InParanoidiQ9DA69.
KOiK19675.
OMAiQSEREDH.
OrthoDBiEOG091G12FE.
PhylomeDBiQ9DA69.
TreeFamiTF323566.

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Miscellaneous databases

PROiQ9DA69.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007867.
CleanExiMM_1700019E19RIK.
GenevisibleiQ9DA69. MM.

Family and domain databases

InterProiIPR029302. IFT43.
[Graphical view]
PfamiPF15305. IFT43. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFT43_MOUSE
AccessioniPrimary (citable) accession number: Q9DA69
Secondary accession number(s): Q8CFI3, Q8K213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.