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Protein

Sperm acrosome membrane-associated protein 1

Gene

Spaca1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in sperm-egg fusion.By similarity

GO - Biological processi

  • acrosome assembly Source: MGI
  • spermatogenesis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome membrane-associated protein 1
Gene namesi
Name:Spaca1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914902. Spaca1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 231ExtracellularSequence analysisAdd BLAST203
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 305CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • acrosomal membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000024815329 – 305Sperm acrosome membrane-associated protein 1Add BLAST277

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Modified residuei266PhosphoserineBy similarity1
Modified residuei301PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9DA48.
PRIDEiQ9DA48.

PTM databases

iPTMnetiQ9DA48.
PhosphoSitePlusiQ9DA48.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028264.
CleanExiMM_SPACA1.
ExpressionAtlasiQ9DA48. baseline and differential.
GenevisibleiQ9DA48. MM.

Structurei

3D structure databases

ProteinModelPortaliQ9DA48.
SMRiQ9DA48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 90Glu-richAdd BLAST45

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFV6. Eukaryota.
ENOG410YPX9. LUCA.
GeneTreeiENSGT00390000004211.
HOGENOMiHOG000049221.
HOVERGENiHBG080320.
InParanoidiQ9DA48.
OMAiWGAKAST.
OrthoDBiEOG091G0M9J.
PhylomeDBiQ9DA48.
TreeFamiTF336918.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DA48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARGAGCPA GLLAVGWLIL VGLQASQASN VTSSGGGVQE PAVAREGESE
60 70 80 90 100
SESESEEEAE NEGEVPESET TAEADAEEEV QNRTIVKEVE FGMCTVTCGV
110 120 130 140 150
GIREVILTNG CPGGESKCVV RVEECRGPVD CGWGKPISEN LDSARLSCVH
160 170 180 190 200
ISPENRFKYV WKLLKPDQQP VILTNDSAVL EITREIRPLA FECDTLDNNE
210 220 230 240 250
MVASVKFTVY TTNELQMRRS SRPDTDAVLV FVLTIGVIIC IFVIFVLIFI
260 270 280 290 300
IINWAAVKSF WGSKTSATEI QSELSSMRYK DSTSLDQSPT DIPVHEDDAL

SEWNE
Length:305
Mass (Da):33,343
Last modified:June 1, 2001 - v1
Checksum:i9D68F7322E2DB398
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006187 mRNA. Translation: BAB24447.1.
CCDSiCCDS18026.1.
RefSeqiNP_080569.1. NM_026293.3.
UniGeneiMm.55848.

Genome annotation databases

EnsembliENSMUST00000029927; ENSMUSP00000029927; ENSMUSG00000028264.
GeneIDi67652.
KEGGimmu:67652.
UCSCiuc008sfz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006187 mRNA. Translation: BAB24447.1.
CCDSiCCDS18026.1.
RefSeqiNP_080569.1. NM_026293.3.
UniGeneiMm.55848.

3D structure databases

ProteinModelPortaliQ9DA48.
SMRiQ9DA48.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9DA48.
PhosphoSitePlusiQ9DA48.

Proteomic databases

PaxDbiQ9DA48.
PRIDEiQ9DA48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029927; ENSMUSP00000029927; ENSMUSG00000028264.
GeneIDi67652.
KEGGimmu:67652.
UCSCiuc008sfz.1. mouse.

Organism-specific databases

CTDi81833.
MGIiMGI:1914902. Spaca1.

Phylogenomic databases

eggNOGiENOG410IFV6. Eukaryota.
ENOG410YPX9. LUCA.
GeneTreeiENSGT00390000004211.
HOGENOMiHOG000049221.
HOVERGENiHBG080320.
InParanoidiQ9DA48.
OMAiWGAKAST.
OrthoDBiEOG091G0M9J.
PhylomeDBiQ9DA48.
TreeFamiTF336918.

Miscellaneous databases

PROiQ9DA48.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028264.
CleanExiMM_SPACA1.
ExpressionAtlasiQ9DA48. baseline and differential.
GenevisibleiQ9DA48. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSACA1_MOUSE
AccessioniPrimary (citable) accession number: Q9DA48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.