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Protein

Protein lifeguard 4

Gene

Tmbim4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 4
Alternative name(s):
Transmembrane BAX inhibitor motif-containing protein 4
Z-protein
Gene namesi
Name:Tmbim4
Synonyms:Lfg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1915462. Tmbim4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence analysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Topological domaini60 – 689LumenalSequence analysis
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 978CytoplasmicSequence analysis
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Topological domaini119 – 1202LumenalSequence analysis
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST
Topological domaini142 – 15110CytoplasmicSequence analysis
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 1753LumenalSequence analysis
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Topological domaini197 – 20812CytoplasmicSequence analysisAdd
BLAST
Intramembranei209 – 22921HelicalSequence analysisAdd
BLAST
Topological domaini230 – 2389CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Protein lifeguard 4PRO_0000179093Add
BLAST

Proteomic databases

PaxDbiQ9DA39.
PRIDEiQ9DA39.

Expressioni

Gene expression databases

BgeeiQ9DA39.
CleanExiMM_TMBIM4.
ExpressionAtlasiQ9DA39. baseline and differential.
GenevisibleiQ9DA39. MM.

Interactioni

Subunit structurei

Interacts with ITPR3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020446.

Structurei

3D structure databases

ProteinModelPortaliQ9DA39.
SMRiQ9DA39. Positions 71-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2322. Eukaryota.
COG0670. LUCA.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ9DA39.
KOiK06890.
OMAiTMIGRAT.
PhylomeDBiQ9DA39.
TreeFamiTF321860.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DA39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTDPGYPR SSIEDDFNYG SCVASASVHI RMAFLRKVYS ILSLQVLLTT
60 70 80 90 100
VTSALFLYFQ ALRTFVHESP ALIVVFALGS LGLIFALTLH RHTHPLNLYL
110 120 130 140 150
LFAFTLSESL AVAAVVTFYD VYLVLQAFIM TTAVFLGLTA YTLQSKRDFT
160 170 180 190 200
KFGAGLFAGL WILCLAGFLK LFFYSETMEL VLASLGALLF CGFIIYDTHS
210 220 230
LMHRLSPEEY VIAAISLYMD IINLFLHLLK FLEAVNKK
Length:238
Mass (Da):26,647
Last modified:June 1, 2001 - v1
Checksum:i67F3B6ECA496C9F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006207 mRNA. Translation: BAB24458.1.
CCDSiCCDS24205.1.
RefSeqiNP_080893.1. NM_026617.3.
UniGeneiMm.157426.

Genome annotation databases

EnsembliENSMUST00000020446; ENSMUSP00000020446; ENSMUSG00000020225.
GeneIDi68212.
KEGGimmu:68212.
UCSCiuc007hey.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006207 mRNA. Translation: BAB24458.1.
CCDSiCCDS24205.1.
RefSeqiNP_080893.1. NM_026617.3.
UniGeneiMm.157426.

3D structure databases

ProteinModelPortaliQ9DA39.
SMRiQ9DA39. Positions 71-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020446.

Proteomic databases

PaxDbiQ9DA39.
PRIDEiQ9DA39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020446; ENSMUSP00000020446; ENSMUSG00000020225.
GeneIDi68212.
KEGGimmu:68212.
UCSCiuc007hey.1. mouse.

Organism-specific databases

CTDi51643.
MGIiMGI:1915462. Tmbim4.

Phylogenomic databases

eggNOGiKOG2322. Eukaryota.
COG0670. LUCA.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ9DA39.
KOiK06890.
OMAiTMIGRAT.
PhylomeDBiQ9DA39.
TreeFamiTF321860.

Miscellaneous databases

ChiTaRSiTmbim4. mouse.
PROiQ9DA39.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DA39.
CleanExiMM_TMBIM4.
ExpressionAtlasiQ9DA39. baseline and differential.
GenevisibleiQ9DA39. MM.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "LFG: a candidate apoptosis regulatory gene family."
    Hu L., Smith T.F., Goldberger G.
    Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiLFG4_MOUSE
AccessioniPrimary (citable) accession number: Q9DA39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.