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Q9DA32

- SUN5_MOUSE

UniProt

Q9DA32 - SUN5_MOUSE

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Protein

SUN domain-containing protein 5

Gene

Sun5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. spermatogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing protein 5
Alternative name(s):
Sperm-associated antigen 4-like protein
Gene namesi
Name:Sun5
Synonyms:Spag4l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1923657. Sun5.

Subcellular locationi

Nucleus inner membrane 1 Publication; Single-pass membrane protein 1 Publication
Note: Isoform 1 is restricted to the apical nuclear region of round spermatids that face the acrosomic vesicle.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373SUN domain-containing protein 5PRO_0000218920Add
BLAST

Proteomic databases

PaxDbiQ9DA32.
PRIDEiQ9DA32.

PTM databases

PhosphoSiteiQ9DA32.

Expressioni

Tissue specificityi

Testis-specific, abundantly expressed in spermatocytes and round spermatids.1 Publication

Gene expression databases

BgeeiQ9DA32.
CleanExiMM_SPAG4L.
GenevestigatoriQ9DA32.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028982.

Structurei

3D structure databases

ProteinModelPortaliQ9DA32.
SMRiQ9DA32. Positions 172-359.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 103103NuclearSequence AnalysisAdd
BLAST
Topological domaini121 – 373253Perinuclear spaceSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei104 – 12017HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 362159SUNPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili136 – 18045Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 SUN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277835.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000007503.
HOVERGENiHBG055206.
InParanoidiQ9DA32.
OrthoDBiEOG7J446H.
TreeFamiTF323915.

Family and domain databases

InterProiIPR012919. Sad1_UNC_C.
[Graphical view]
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9DA32-1) [UniParc]FASTAAdd to Basket

Also known as: SPAG4L-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRTRNIGAL CTLPEDTTHS GRPRRGVQRS YISRMAEPAP ANMNDPLLLP
60 70 80 90 100
LRMNTPGLSL VQILLGYMSW LTYLACFLRT QTQQVFLNTC RCKLFCQKVM
110 120 130 140 150
EKMGLLVLCV FGFWMFSMHL PSKVEVWQDD SINGPLQSLR MYQEKVRHHT
160 170 180 190 200
GEIQDLRGSM NQLIAKLQKM EAISDEQKMA QKIMKMIQGD YIEKPDFALK
210 220 230 240 250
SIGASIDFEH TSATYNHDKA RSYWNWIRLW NYAQPPDVIL EPNVTPGNCW
260 270 280 290 300
AFASDRGQVT IRLAQKVYLS NITLQHIPKT ISLSGSPDTA PKDIVIYGLE
310 320 330 340 350
SLPREEVFLG AFQFQPENVI QMFQLQNLPP RSFAAVKVKI SSNWGNPRFT
360 370
CMYRVRVHGS VTPPKDSHLE PLS
Length:373
Mass (Da):42,653
Last modified:May 29, 2013 - v2
Checksum:i5082E36162B5C012
GO
Isoform 2 (identifier: Q9DA32-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-69: Missing.

Show »
Length:347
Mass (Da):39,801
Checksum:iE0F2067946E091AD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti287 – 2871P → L in AAP69223. (PubMed:15552040)Curated
Sequence conflicti287 – 2871P → L in BAB24468. (PubMed:16141072)Curated
Sequence conflicti294 – 2941I → F in AAP69223. (PubMed:15552040)Curated
Sequence conflicti294 – 2941I → F in BAB24468. (PubMed:16141072)Curated
Sequence conflicti319 – 3224VIQM → IIQT in AAP69223. (PubMed:15552040)Curated
Sequence conflicti319 – 3224VIQM → IIQT in BAB24468. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei44 – 6926Missing in isoform 2. 2 PublicationsVSP_046528Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY307077 mRNA. Translation: AAP69223.1.
FJ667498 mRNA. Translation: ACV74249.1.
AK006225 mRNA. Translation: BAB24468.1.
RefSeqiNP_083875.1. NM_029599.1.
UniGeneiMm.33629.

Genome annotation databases

EnsembliENSMUST00000028982; ENSMUSP00000028982; ENSMUSG00000027480.
GeneIDi76407.
KEGGimmu:76407.
UCSCiuc008nim.1. mouse. [Q9DA32-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY307077 mRNA. Translation: AAP69223.1 .
FJ667498 mRNA. Translation: ACV74249.1 .
AK006225 mRNA. Translation: BAB24468.1 .
RefSeqi NP_083875.1. NM_029599.1.
UniGenei Mm.33629.

3D structure databases

ProteinModelPortali Q9DA32.
SMRi Q9DA32. Positions 172-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000028982.

PTM databases

PhosphoSitei Q9DA32.

Proteomic databases

PaxDbi Q9DA32.
PRIDEi Q9DA32.

Protocols and materials databases

DNASUi 76407.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028982 ; ENSMUSP00000028982 ; ENSMUSG00000027480 .
GeneIDi 76407.
KEGGi mmu:76407.
UCSCi uc008nim.1. mouse. [Q9DA32-1 ]

Organism-specific databases

CTDi 140732.
MGIi MGI:1923657. Sun5.

Phylogenomic databases

eggNOGi NOG277835.
GeneTreei ENSGT00390000011587.
HOGENOMi HOG000007503.
HOVERGENi HBG055206.
InParanoidi Q9DA32.
OrthoDBi EOG7J446H.
TreeFami TF323915.

Miscellaneous databases

NextBioi 345089.
PROi Q9DA32.
SOURCEi Search...

Gene expression databases

Bgeei Q9DA32.
CleanExi MM_SPAG4L.
Genevestigatori Q9DA32.

Family and domain databases

InterProi IPR012919. Sad1_UNC_C.
[Graphical view ]
Pfami PF07738. Sad1_UNC. 1 hit.
[Graphical view ]
PROSITEi PS51469. SUN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of cDNA of SRG4, a mouse spermatogenesis related gene and expression in mouse different developing stages."
    Xing X.W., Li L.Y., Liu G., Lu G.X.
    Yi Chuan Xue Bao 31:1066-1071(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "SPAG4L/SPAG4L-2 are testis-specific SUN domain proteins restricted to the apical nuclear envelope of round spermatids facing the acrosome."
    Frohnert C., Schweizer S., Hoyer-Fender S.
    Mol. Hum. Reprod. 17:207-218(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiSUN5_MOUSE
AccessioniPrimary (citable) accession number: Q9DA32
Secondary accession number(s): D2DR64, Q5DT38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: May 29, 2013
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3