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Q9DA32 (SUN5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SUN domain-containing protein 5
Alternative name(s):
Sperm-associated antigen 4-like protein
Gene names
Name:Sun5
Synonyms:Spag4l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus inner membrane; Single-pass membrane protein. Note: Isoform 1 is restricted to the apical nuclear region of round spermatids that face the acrosomic vesicle. Ref.2

Tissue specificity

Testis-specific, abundantly expressed in spermatocytes and round spermatids. Ref.1

Sequence similarities

Contains 1 SUN domain.

Ontologies

Keywords
   Cellular componentMembrane
Nucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processspermatogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nuclear inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9DA32-1)

Also known as: SPAG4L-2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9DA32-2)

The sequence of this isoform differs from the canonical sequence as follows:
     44-69: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373SUN domain-containing protein 5
PRO_0000218920

Regions

Topological domain1 – 103103Nuclear Potential
Transmembrane104 – 12017Helical; Potential
Topological domain121 – 373253Perinuclear space Potential
Domain204 – 362159SUN
Coiled coil136 – 18045 Potential

Natural variations

Alternative sequence44 – 6926Missing in isoform 2.
VSP_046528

Experimental info

Sequence conflict2871P → L in AAP69223. Ref.1
Sequence conflict2871P → L in BAB24468. Ref.3
Sequence conflict2941I → F in AAP69223. Ref.1
Sequence conflict2941I → F in BAB24468. Ref.3
Sequence conflict319 – 3224VIQM → IIQT in AAP69223. Ref.1
Sequence conflict319 – 3224VIQM → IIQT in BAB24468. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (SPAG4L-2) [UniParc].

Last modified May 29, 2013. Version 2.
Checksum: 5082E36162B5C012

FASTA37342,653
        10         20         30         40         50         60 
MPRTRNIGAL CTLPEDTTHS GRPRRGVQRS YISRMAEPAP ANMNDPLLLP LRMNTPGLSL 

        70         80         90        100        110        120 
VQILLGYMSW LTYLACFLRT QTQQVFLNTC RCKLFCQKVM EKMGLLVLCV FGFWMFSMHL 

       130        140        150        160        170        180 
PSKVEVWQDD SINGPLQSLR MYQEKVRHHT GEIQDLRGSM NQLIAKLQKM EAISDEQKMA 

       190        200        210        220        230        240 
QKIMKMIQGD YIEKPDFALK SIGASIDFEH TSATYNHDKA RSYWNWIRLW NYAQPPDVIL 

       250        260        270        280        290        300 
EPNVTPGNCW AFASDRGQVT IRLAQKVYLS NITLQHIPKT ISLSGSPDTA PKDIVIYGLE 

       310        320        330        340        350        360 
SLPREEVFLG AFQFQPENVI QMFQLQNLPP RSFAAVKVKI SSNWGNPRFT CMYRVRVHGS 

       370 
VTPPKDSHLE PLS 

« Hide

Isoform 2 [UniParc].

Checksum: E0F2067946E091AD
Show »

FASTA34739,801

References

« Hide 'large scale' references
[1]"Cloning of cDNA of SRG4, a mouse spermatogenesis related gene and expression in mouse different developing stages."
Xing X.W., Li L.Y., Liu G., Lu G.X.
Yi Chuan Xue Bao 31:1066-1071(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Strain: C57BL/6J.
Tissue: Testis.
[2]"SPAG4L/SPAG4L-2 are testis-specific SUN domain proteins restricted to the apical nuclear envelope of round spermatids facing the acrosome."
Frohnert C., Schweizer S., Hoyer-Fender S.
Mol. Hum. Reprod. 17:207-218(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY307077 mRNA. Translation: AAP69223.1.
FJ667498 mRNA. Translation: ACV74249.1.
AK006225 mRNA. Translation: BAB24468.1.
RefSeqNP_083875.1. NM_029599.1.
UniGeneMm.33629.

3D structure databases

ProteinModelPortalQ9DA32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000028982.

PTM databases

PhosphoSiteQ9DA32.

Proteomic databases

PaxDbQ9DA32.
PRIDEQ9DA32.

Protocols and materials databases

DNASU76407.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028982; ENSMUSP00000028982; ENSMUSG00000027480.
GeneID76407.
KEGGmmu:76407.
UCSCuc008nim.1. mouse. [Q9DA32-1]

Organism-specific databases

CTD140732.
MGIMGI:1923657. Sun5.

Phylogenomic databases

eggNOGNOG277835.
GeneTreeENSGT00390000011587.
HOGENOMHOG000007503.
HOVERGENHBG055206.
InParanoidQ9DA32.
OrthoDBEOG7J446H.
TreeFamTF323915.

Gene expression databases

BgeeQ9DA32.
CleanExMM_SPAG4L.
GenevestigatorQ9DA32.

Family and domain databases

InterProIPR012919. Sad1_UNC_C.
[Graphical view]
PfamPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEPS51469. SUN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio345089.
PROQ9DA32.
SOURCESearch...

Entry information

Entry nameSUN5_MOUSE
AccessionPrimary (citable) accession number: Q9DA32
Secondary accession number(s): D2DR64, Q5DT38
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: May 29, 2013
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot