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Q9DA32

- SUN5_MOUSE

UniProt

Q9DA32 - SUN5_MOUSE

Protein

SUN domain-containing protein 5

Gene

Sun5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (29 May 2013)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. spermatogenesis Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SUN domain-containing protein 5
    Alternative name(s):
    Sperm-associated antigen 4-like protein
    Gene namesi
    Name:Sun5
    Synonyms:Spag4l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1923657. Sun5.

    Subcellular locationi

    Nucleus inner membrane 1 Publication; Single-pass membrane protein 1 Publication
    Note: Isoform 1 is restricted to the apical nuclear region of round spermatids that face the acrosomic vesicle.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. nuclear inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373SUN domain-containing protein 5PRO_0000218920Add
    BLAST

    Proteomic databases

    PaxDbiQ9DA32.
    PRIDEiQ9DA32.

    PTM databases

    PhosphoSiteiQ9DA32.

    Expressioni

    Tissue specificityi

    Testis-specific, abundantly expressed in spermatocytes and round spermatids.1 Publication

    Gene expression databases

    BgeeiQ9DA32.
    CleanExiMM_SPAG4L.
    GenevestigatoriQ9DA32.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000028982.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DA32.
    SMRiQ9DA32. Positions 172-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 103103NuclearSequence AnalysisAdd
    BLAST
    Topological domaini121 – 373253Perinuclear spaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei104 – 12017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 362159SUNPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili136 – 18045Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SUN domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277835.
    GeneTreeiENSGT00390000011587.
    HOGENOMiHOG000007503.
    HOVERGENiHBG055206.
    InParanoidiQ9DA32.
    OrthoDBiEOG7J446H.
    TreeFamiTF323915.

    Family and domain databases

    InterProiIPR012919. Sad1_UNC_C.
    [Graphical view]
    PfamiPF07738. Sad1_UNC. 1 hit.
    [Graphical view]
    PROSITEiPS51469. SUN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9DA32-1) [UniParc]FASTAAdd to Basket

    Also known as: SPAG4L-2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRTRNIGAL CTLPEDTTHS GRPRRGVQRS YISRMAEPAP ANMNDPLLLP    50
    LRMNTPGLSL VQILLGYMSW LTYLACFLRT QTQQVFLNTC RCKLFCQKVM 100
    EKMGLLVLCV FGFWMFSMHL PSKVEVWQDD SINGPLQSLR MYQEKVRHHT 150
    GEIQDLRGSM NQLIAKLQKM EAISDEQKMA QKIMKMIQGD YIEKPDFALK 200
    SIGASIDFEH TSATYNHDKA RSYWNWIRLW NYAQPPDVIL EPNVTPGNCW 250
    AFASDRGQVT IRLAQKVYLS NITLQHIPKT ISLSGSPDTA PKDIVIYGLE 300
    SLPREEVFLG AFQFQPENVI QMFQLQNLPP RSFAAVKVKI SSNWGNPRFT 350
    CMYRVRVHGS VTPPKDSHLE PLS 373
    Length:373
    Mass (Da):42,653
    Last modified:May 29, 2013 - v2
    Checksum:i5082E36162B5C012
    GO
    Isoform 2 (identifier: Q9DA32-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         44-69: Missing.

    Show »
    Length:347
    Mass (Da):39,801
    Checksum:iE0F2067946E091AD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti287 – 2871P → L in AAP69223. (PubMed:15552040)Curated
    Sequence conflicti287 – 2871P → L in BAB24468. (PubMed:16141072)Curated
    Sequence conflicti294 – 2941I → F in AAP69223. (PubMed:15552040)Curated
    Sequence conflicti294 – 2941I → F in BAB24468. (PubMed:16141072)Curated
    Sequence conflicti319 – 3224VIQM → IIQT in AAP69223. (PubMed:15552040)Curated
    Sequence conflicti319 – 3224VIQM → IIQT in BAB24468. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei44 – 6926Missing in isoform 2. 2 PublicationsVSP_046528Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY307077 mRNA. Translation: AAP69223.1.
    FJ667498 mRNA. Translation: ACV74249.1.
    AK006225 mRNA. Translation: BAB24468.1.
    RefSeqiNP_083875.1. NM_029599.1.
    UniGeneiMm.33629.

    Genome annotation databases

    EnsembliENSMUST00000028982; ENSMUSP00000028982; ENSMUSG00000027480.
    GeneIDi76407.
    KEGGimmu:76407.
    UCSCiuc008nim.1. mouse. [Q9DA32-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY307077 mRNA. Translation: AAP69223.1 .
    FJ667498 mRNA. Translation: ACV74249.1 .
    AK006225 mRNA. Translation: BAB24468.1 .
    RefSeqi NP_083875.1. NM_029599.1.
    UniGenei Mm.33629.

    3D structure databases

    ProteinModelPortali Q9DA32.
    SMRi Q9DA32. Positions 172-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000028982.

    PTM databases

    PhosphoSitei Q9DA32.

    Proteomic databases

    PaxDbi Q9DA32.
    PRIDEi Q9DA32.

    Protocols and materials databases

    DNASUi 76407.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028982 ; ENSMUSP00000028982 ; ENSMUSG00000027480 .
    GeneIDi 76407.
    KEGGi mmu:76407.
    UCSCi uc008nim.1. mouse. [Q9DA32-1 ]

    Organism-specific databases

    CTDi 140732.
    MGIi MGI:1923657. Sun5.

    Phylogenomic databases

    eggNOGi NOG277835.
    GeneTreei ENSGT00390000011587.
    HOGENOMi HOG000007503.
    HOVERGENi HBG055206.
    InParanoidi Q9DA32.
    OrthoDBi EOG7J446H.
    TreeFami TF323915.

    Miscellaneous databases

    NextBioi 345089.
    PROi Q9DA32.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DA32.
    CleanExi MM_SPAG4L.
    Genevestigatori Q9DA32.

    Family and domain databases

    InterProi IPR012919. Sad1_UNC_C.
    [Graphical view ]
    Pfami PF07738. Sad1_UNC. 1 hit.
    [Graphical view ]
    PROSITEi PS51469. SUN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cDNA of SRG4, a mouse spermatogenesis related gene and expression in mouse different developing stages."
      Xing X.W., Li L.Y., Liu G., Lu G.X.
      Yi Chuan Xue Bao 31:1066-1071(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "SPAG4L/SPAG4L-2 are testis-specific SUN domain proteins restricted to the apical nuclear envelope of round spermatids facing the acrosome."
      Frohnert C., Schweizer S., Hoyer-Fender S.
      Mol. Hum. Reprod. 17:207-218(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.

    Entry informationi

    Entry nameiSUN5_MOUSE
    AccessioniPrimary (citable) accession number: Q9DA32
    Secondary accession number(s): D2DR64, Q5DT38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: May 29, 2013
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3