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Protein

Lysozyme-like protein 6

Gene

Lyzl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (By similarity).By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54PROSITE-ProRule annotation1
Active sitei71PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase
Biological processFertilization

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme-like protein 6 (EC:3.2.1.17)
Gene namesi
Name:Lyzl6
Synonyms:Lyc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916694 Lyzl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024064120 – 148Lysozyme-like protein 6Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 145PROSITE-ProRule annotation
Disulfide bondi49 ↔ 133PROSITE-ProRule annotation
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
Disulfide bondi94 ↔ 112PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9DA11
PaxDbiQ9DA11
PeptideAtlasiQ9DA11
PRIDEiQ9DA11

PTM databases

PhosphoSitePlusiQ9DA11

Expressioni

Tissue specificityi

Expressed strongly in testis and epididymis and weakly in seminal vesicle, vas deferens, kidney and spleen (PubMed:24013621). Highly expressed in primary spermatocytes and round spermatids (at protein level) (PubMed:24013621).1 Publication

Developmental stagei

In testis expressed from day 21 during postnatal development (PubMed:24013621). In the epidydimis, first detected at day 28 and high expression is maintained until day 35. Thereafter, level declines gradually (PubMed:24013621).1 Publication

Gene expression databases

BgeeiENSMUSG00000020945
CleanExiMM_LYZL6
ExpressionAtlasiQ9DA11 baseline and differential
GenevisibleiQ9DA11 MM

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021328

Structurei

3D structure databases

ProteinModelPortaliQ9DA11
SMRiQ9DA11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JC6R Eukaryota
ENOG4111501 LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiQ9DA11
KOiK01185
OMAiFRHWNGW
OrthoDBiEOG091G0R9V
PhylomeDBiQ9DA11
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DA11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKALFICVA SCLLVVNDGN IIHRCSLAKI LYEEDLDGFE GYSLPDWLCL
60 70 80 90 100
AFVESNFNIS KVNENVDGSF DYGIFQINSR YWCNDYQSHS ENFCHVDCQE
110 120 130 140
LLSPNLISTI HCAKKIVSGP GGMKNWVEWK LHCLGRPLSY WMTGCHLG
Length:148
Mass (Da):16,818
Last modified:June 1, 2001 - v1
Checksum:i81C6F74A2387D97A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566284 mRNA Translation: AAS68631.1
AK006279 mRNA Translation: BAB24499.1
BC048617 mRNA Translation: AAH48617.1
CCDSiCCDS25519.1
RefSeqiNP_081359.1, NM_027083.1
XP_006534178.1, XM_006534115.3
UniGeneiMm.275677

Genome annotation databases

EnsembliENSMUST00000021328; ENSMUSP00000021328; ENSMUSG00000020945
ENSMUST00000107014; ENSMUSP00000102628; ENSMUSG00000020945
GeneIDi69444
KEGGimmu:69444
UCSCiuc007lvl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLYZL6_MOUSE
AccessioniPrimary (citable) accession number: Q9DA11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health