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Protein

DET1- and DDB1-associated protein 1

Gene

Dda1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity).By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
DET1- and DDB1-associated protein 1
Gene namesi
Name:Dda1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913748. Dda1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 102101DET1- and DDB1-associated protein 1PRO_0000310271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei33 – 331PhosphoserineBy similarity
Modified residuei95 – 951PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D9Z5.
MaxQBiQ9D9Z5.
PaxDbiQ9D9Z5.
PRIDEiQ9D9Z5.

PTM databases

iPTMnetiQ9D9Z5.
PhosphoSiteiQ9D9Z5.

Expressioni

Gene expression databases

BgeeiQ9D9Z5.
CleanExiMM_DDA1.
ExpressionAtlasiQ9D9Z5. baseline and differential.
GenevisibleiQ9D9Z5. MM.

Interactioni

Subunit structurei

Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes (By similarity).By similarity

Protein-protein interaction databases

BioGridi211519. 6 interactions.
IntActiQ9D9Z5. 6 interactions.
STRINGi10090.ENSMUSP00000121042.

Family & Domainsi

Sequence similaritiesi

Belongs to the DDA1 family.Curated

Phylogenomic databases

eggNOGiKOG4816. Eukaryota.
ENOG41120QM. LUCA.
GeneTreeiENSGT00390000007029.
HOGENOMiHOG000006384.
HOVERGENiHBG055081.
InParanoidiQ9D9Z5.
KOiK11792.
OMAiRTDSQDM.
OrthoDBiEOG7K3TP9.
PhylomeDBiQ9D9Z5.
TreeFamiTF323534.

Family and domain databases

InterProiIPR018276. Ub_ligase_Det1/DDB1-complexing.
[Graphical view]
PfamiPF10172. DDA1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D9Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFLKGLPV YNKSNFSRFH ADSVCKASNR RPSVYLPTRE YPSEQIIVTE
60 70 80 90 100
KTNILLRYLH QQWDKKNAAK KRDQEQVEAE GESSAPPRKV ARTDSPDMPE

DT
Length:102
Mass (Da):11,753
Last modified:June 1, 2001 - v1
Checksum:iC4393C23A8589F09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006318 mRNA. Translation: BAB24524.1.
AK032966 mRNA. Translation: BAC28103.1.
AK149980 mRNA. Translation: BAE29210.1.
AK168085 mRNA. Translation: BAE40058.1.
BC034701 mRNA. Translation: AAH34701.1.
BC093523 mRNA. Translation: AAH93523.1.
CCDSiCCDS52584.1.
RefSeqiNP_001281187.1. NM_001294258.1.
NP_001281188.1. NM_001294259.1.
NP_079876.1. NM_025600.2.
UniGeneiMm.260360.

Genome annotation databases

EnsembliENSMUST00000124745; ENSMUSP00000121042; ENSMUSG00000074247.
GeneIDi66498.
KEGGimmu:66498.
UCSCiuc009mdi.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006318 mRNA. Translation: BAB24524.1.
AK032966 mRNA. Translation: BAC28103.1.
AK149980 mRNA. Translation: BAE29210.1.
AK168085 mRNA. Translation: BAE40058.1.
BC034701 mRNA. Translation: AAH34701.1.
BC093523 mRNA. Translation: AAH93523.1.
CCDSiCCDS52584.1.
RefSeqiNP_001281187.1. NM_001294258.1.
NP_001281188.1. NM_001294259.1.
NP_079876.1. NM_025600.2.
UniGeneiMm.260360.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211519. 6 interactions.
IntActiQ9D9Z5. 6 interactions.
STRINGi10090.ENSMUSP00000121042.

PTM databases

iPTMnetiQ9D9Z5.
PhosphoSiteiQ9D9Z5.

Proteomic databases

EPDiQ9D9Z5.
MaxQBiQ9D9Z5.
PaxDbiQ9D9Z5.
PRIDEiQ9D9Z5.

Protocols and materials databases

DNASUi66498.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124745; ENSMUSP00000121042; ENSMUSG00000074247.
GeneIDi66498.
KEGGimmu:66498.
UCSCiuc009mdi.3. mouse.

Organism-specific databases

CTDi79016.
MGIiMGI:1913748. Dda1.

Phylogenomic databases

eggNOGiKOG4816. Eukaryota.
ENOG41120QM. LUCA.
GeneTreeiENSGT00390000007029.
HOGENOMiHOG000006384.
HOVERGENiHBG055081.
InParanoidiQ9D9Z5.
KOiK11792.
OMAiRTDSQDM.
OrthoDBiEOG7K3TP9.
PhylomeDBiQ9D9Z5.
TreeFamiTF323534.

Miscellaneous databases

PROiQ9D9Z5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D9Z5.
CleanExiMM_DDA1.
ExpressionAtlasiQ9D9Z5. baseline and differential.
GenevisibleiQ9D9Z5. MM.

Family and domain databases

InterProiIPR018276. Ub_ligase_Det1/DDB1-complexing.
[Graphical view]
PfamiPF10172. DDA1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Testis and Wolffian duct.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver, Pancreas and Testis.

Entry informationi

Entry nameiDDA1_MOUSE
AccessioniPrimary (citable) accession number: Q9D9Z5
Secondary accession number(s): Q3UDQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.