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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

Pdha2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandPyruvateUniRule annotation, Thiamine pyrophosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alphaUniRule annotation (EC:1.2.4.1UniRule annotation)
Gene namesi
Name:Pdha2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97533. Pdha2.

Subcellular locationi

Structurei

3D structure databases

ProteinModelPortaliQ9D9X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 362E1_dhInterPro annotationAdd BLAST295

Phylogenomic databases

eggNOGiKOG0225. Eukaryota.
COG1071. LUCA.
HOVERGENiHBG001863.

Family and domain databases

InterProiView protein in InterPro
IPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
PfamiView protein in Pfam
PF00676. E1_dh. 1 hit.
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D9X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKMLTAVLS HVFSGMVQKP ALRGLLSSLK FSNDATCDIK KCDLYRLEEG
60 70 80 90 100
PPTSTVLTRA EALKYYRTMQ VIRRMELKAD QLYKQKFIRG FCHLCDGQEA
110 120 130 140 150
CCVGLEAGIN PTDHVITSYR AHGFCYTRGL SVKSILAELN GRKGGCAKGK
160 170 180 190 200
GGSMHMYGKN FYGGNGIVGA QVPLGAGVAF ACKYLKNGQV CLALYGDGAA
210 220 230 240 250
NQGQVFEAYN MSALWKLPCV FICENNLYGM GTSNERSAAS TDYHKKGFII
260 270 280 290 300
PGLRVNGMDI LCVREATKFA ADHCRSGKGP IVMELQTYRY HGHSMSDPGI
310 320 330 340 350
SYRSREEVHN VRSKSDPIML LRERIISNNL SNIEELKEID ADVKKEVEDA
360 370 380 390
AQFATTDPEP AVEDIANYLY HQDPPFEVRG AHKWLKYKSH S
Length:391
Mass (Da):43,426
Last modified:June 1, 2001 - v1
Checksum:i20DE823590485978
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006356 mRNA. Translation: BAB24543.1.
UniGeneiMm.4223.

Similar proteinsi

Entry informationi

Entry nameiQ9D9X9_MOUSE
AccessioniPrimary (citable) accession number: Q9D9X9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: January 31, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)