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Q9D9V3

- ECHD1_MOUSE

UniProt

Q9D9V3 - ECHD1_MOUSE

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Protein

Ethylmalonyl-CoA decarboxylase

Gene

Echdc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level.1 Publication

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.1 Publication
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.1 Publication

Kineticsi

  1. KM=0.96 µM for (S)-ethylmalonyl-CoA (in presence of 0 mM of ATP)1 Publication
  2. KM=6.5 µM for (S)-ethylmalonyl-CoA (in presence of 5 mM of ATP)1 Publication
  3. KM=3.1 µM for (S)-methylmalonyl-CoA (in presence of 0 mM of ATP)1 Publication
  4. KM=15.1 µM for (S)-methylmalonyl-CoA (in presence of 5 mM of ATP)1 Publication

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB
  2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17103.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:Echdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1277169. Echdc1.

Subcellular locationi

Cytoplasmcytosol 1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Ethylmalonyl-CoA decarboxylasePRO_0000273247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei232 – 2321N6-acetyllysine; alternate1 Publication
Modified residuei232 – 2321N6-succinyllysine; alternate1 Publication
Modified residuei316 – 3161N6-succinyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D9V3.
PaxDbiQ9D9V3.
PRIDEiQ9D9V3.

PTM databases

PhosphoSiteiQ9D9V3.

Expressioni

Gene expression databases

BgeeiQ9D9V3.
CleanExiMM_ECHDC1.
ExpressionAtlasiQ9D9V3. baseline and differential.
GenevestigatoriQ9D9V3.

Interactioni

Protein-protein interaction databases

MINTiMINT-1858949.

Structurei

3D structure databases

ProteinModelPortaliQ9D9V3.
SMRiQ9D9V3. Positions 72-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00720000108837.
HOGENOMiHOG000007808.
HOVERGENiHBG054783.
InParanoidiQ9D9V3.
KOiK18426.
OMAiHKHMGLV.
OrthoDBiEOG79W95T.
PhylomeDBiQ9D9V3.
TreeFamiTF315986.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9D9V3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRCEVNSKP ISEYFGIPCE NREMAKCLLT SSLSVRTKLL QTGVSLYNTS
60 70 80 90 100
HGFHEEEVKK ILEQFPGGSI DLLKKQNGIG ILTLNNPNKM NAFSGVMMLQ
110 120 130 140 150
LLERVIELEN WTEGKGLIIH GAKNTFCSGS DLNAVKALST PESGVALSMF
160 170 180 190 200
MQNTLTRFMR LPLISVALVQ GWAMGGGAEL TTACDFRLMT EESVIRFVHK
210 220 230 240 250
EMGIVPSWGG TSRLVEIIGS RQALKVLSGT LKLDSKEALN IGLTDEVLQP
260 270 280 290 300
SDETTALEQA QEWLEKFVSG PPQVIRGLKK SVCSARELYI EEALQNERDV
310 320
LETLWGGPAN LEAIAKKGKH TK
Length:322
Mass (Da):35,467
Last modified:March 1, 2003 - v2
Checksum:iB25E26FEF0611EB1
GO
Isoform 2 (identifier: Q9D9V3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.

Show »
Length:299
Mass (Da):32,727
Checksum:i8C08C7357BA365A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21R → K in BAC26112. (PubMed:16141072)Curated
Sequence conflicti4 – 41C → F in BAE26268. (PubMed:16141072)Curated
Sequence conflicti22 – 221R → Q in BAC26112. (PubMed:16141072)Curated
Sequence conflicti280 – 2801K → Q in BAE26268. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323Missing in isoform 2. 1 PublicationVSP_022499Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003965 mRNA. Translation: BAB23096.1.
AK006444 mRNA. Translation: BAB24592.2.
AK028775 mRNA. Translation: BAC26112.1.
AK145162 mRNA. Translation: BAE26268.1.
AK150932 mRNA. Translation: BAE29969.1.
AK152285 mRNA. Translation: BAE31098.1.
AK153454 mRNA. Translation: BAE32007.1.
AK166589 mRNA. Translation: BAE38876.1.
AK166634 mRNA. Translation: BAE38907.1.
AK166660 mRNA. Translation: BAE38924.1.
BC066183 mRNA. Translation: AAH66183.1.
CCDSiCCDS23760.1. [Q9D9V3-1]
CCDS48528.1. [Q9D9V3-2]
RefSeqiNP_001103665.1. NM_001110195.1. [Q9D9V3-2]
NP_080131.4. NM_025855.4. [Q9D9V3-1]
UniGeneiMm.28930.

Genome annotation databases

EnsembliENSMUST00000020034; ENSMUSP00000020034; ENSMUSG00000019883. [Q9D9V3-1]
ENSMUST00000160399; ENSMUSP00000125553; ENSMUSG00000019883. [Q9D9V3-2]
GeneIDi52665.
KEGGimmu:52665.
UCSCiuc007esw.2. mouse. [Q9D9V3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003965 mRNA. Translation: BAB23096.1 .
AK006444 mRNA. Translation: BAB24592.2 .
AK028775 mRNA. Translation: BAC26112.1 .
AK145162 mRNA. Translation: BAE26268.1 .
AK150932 mRNA. Translation: BAE29969.1 .
AK152285 mRNA. Translation: BAE31098.1 .
AK153454 mRNA. Translation: BAE32007.1 .
AK166589 mRNA. Translation: BAE38876.1 .
AK166634 mRNA. Translation: BAE38907.1 .
AK166660 mRNA. Translation: BAE38924.1 .
BC066183 mRNA. Translation: AAH66183.1 .
CCDSi CCDS23760.1. [Q9D9V3-1 ]
CCDS48528.1. [Q9D9V3-2 ]
RefSeqi NP_001103665.1. NM_001110195.1. [Q9D9V3-2 ]
NP_080131.4. NM_025855.4. [Q9D9V3-1 ]
UniGenei Mm.28930.

3D structure databases

ProteinModelPortali Q9D9V3.
SMRi Q9D9V3. Positions 72-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1858949.

PTM databases

PhosphoSitei Q9D9V3.

Proteomic databases

MaxQBi Q9D9V3.
PaxDbi Q9D9V3.
PRIDEi Q9D9V3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020034 ; ENSMUSP00000020034 ; ENSMUSG00000019883 . [Q9D9V3-1 ]
ENSMUST00000160399 ; ENSMUSP00000125553 ; ENSMUSG00000019883 . [Q9D9V3-2 ]
GeneIDi 52665.
KEGGi mmu:52665.
UCSCi uc007esw.2. mouse. [Q9D9V3-1 ]

Organism-specific databases

CTDi 55862.
MGIi MGI:1277169. Echdc1.

Phylogenomic databases

eggNOGi COG1024.
GeneTreei ENSGT00720000108837.
HOGENOMi HOG000007808.
HOVERGENi HBG054783.
InParanoidi Q9D9V3.
KOi K18426.
OMAi HKHMGLV.
OrthoDBi EOG79W95T.
PhylomeDBi Q9D9V3.
TreeFami TF315986.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17103.

Miscellaneous databases

NextBioi 309291.
PROi Q9D9V3.
SOURCEi Search...

Gene expression databases

Bgeei Q9D9V3.
CleanExi MM_ECHDC1.
ExpressionAtlasi Q9D9V3. baseline and differential.
Genevestigatori Q9D9V3.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view ]
Pfami PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow, Mammary gland, Skin and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Egg.
  3. Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-232 AND LYS-316, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiECHD1_MOUSE
AccessioniPrimary (citable) accession number: Q9D9V3
Secondary accession number(s): Q3U8C0
, Q3UM30, Q8C185, Q9CTC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3