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Q9D9M5 (PHOP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyridoxal phosphate phosphatase PHOSPHO2
EC=3.1.3.74
Gene names
Name:Phospho2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate By similarity.

Catalytic activity

Pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Pyridoxal phosphate phosphatase PHOSPHO2
PRO_0000068834

Sites

Active site81Nucleophile By similarity
Active site101Proton donor By similarity
Metal binding81Magnesium By similarity
Metal binding101Magnesium By similarity
Metal binding1791Magnesium By similarity
Binding site191Substrate By similarity
Binding site991Substrate By similarity

Experimental info

Sequence conflict1861P → Q in BAE21125. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9D9M5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 9E0036C310AD26BE

FASTA24127,563
        10         20         30         40         50         60 
MKVLLVFDFD NTIIDDNSDT WIVQCAPDKK LPIELQDSYQ KGLWTEFMGR VFKYLRDEGV 

        70         80         90        100        110        120 
KADELKRAVT SLPFTSGMIE LLSFLRMNKD RFDCIIISDS NSIFIDWVLE AAAFHDVFDH 

       130        140        150        160        170        180 
VFTNPASFDS SGRLTVKNYH AHSCTRCPKN LCKNTVLGEF IDKQLQKGVR YTRIVYIGDG 

       190        200        210        220        230        240 
GNDVCPVTFL KKNDVAMPRE GYTLHRTLAK MSQNLEPMES SIVVWSSGVE IISHLQFLIK 


M

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head and Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK006724 mRNA. Translation: BAB24714.1.
AK132362 mRNA. Translation: BAE21125.1.
AK159551 mRNA. Translation: BAE35176.1.
AL845261 Genomic DNA. Translation: CAM16374.1.
BC025612 mRNA. Translation: AAH25612.1.
BC031523 mRNA. Translation: AAH31523.1.
IPIIPI00112884.
RefSeqNP_082797.1. NM_028521.2.
UniGeneMm.9621.

3D structure databases

ProteinModelPortalQ9D9M5.
SMRQ9D9M5. Positions 1-240.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9D9M5.

Proteomic databases

PRIDEQ9D9M5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028494; ENSMUSP00000028494; ENSMUSG00000027088.
ENSMUST00000112266; ENSMUSP00000107885; ENSMUSG00000027088.
GeneID73373.
KEGGmmu:73373.
UCSCuc008jyp.1. mouse.

Organism-specific databases

CTD493911.
MGIMGI:1920623. Phospho2.

Phylogenomic databases

GeneTreeENSGT00390000007741.
HOGENOMHBG319786.
HOVERGENHBG080058.
InParanoidQ9D9M5.
OMADWVLEAT.
OrthoDBEOG4S4PH0.
PhylomeDBQ9D9M5.

Gene expression databases

ArrayExpressQ9D9M5.
BgeeQ9D9M5.
CleanExMM_PHOSPHO2.
GenevestigatorQ9D9M5.
GermOnlineENSMUSG00000027088. Mus musculus.

Family and domain databases

InterProIPR023214. HAD-like_dom.
IPR006383. HAD-SF_hydro_IB_PSP-like.
IPR016965. Pase_PHOSPHO-typ.
IPR006384. PyrdxlP_Pase-rel.
[Graphical view]
Gene3DG3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KOK13248.
PfamPF06888. Put_Phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF031051. PyrdxlP_Pase_PHOSPHO2. 1 hit.
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01489. DKMTPPase-SF. 1 hit.
TIGR01488. HAD-SF-IB. 1 hit.
ProtoNetSearch...

Other

NextBio338097.
SOURCESearch...

Entry information

Entry namePHOP2_MOUSE
AccessionPrimary (citable) accession number: Q9D9M5
Secondary accession number(s): A2AR04, Q3V1M5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents