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Protein

Pyridoxal phosphate phosphatase PHOSPHO2

Gene

Phospho2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate (By similarity).By similarity

Catalytic activityi

Pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei8NucleophileBy similarity1
Metal bindingi8MagnesiumBy similarity1
Active sitei10Proton donorBy similarity1
Metal bindingi10MagnesiumBy similarity1
Binding sitei19SubstrateBy similarity1
Binding sitei99SubstrateBy similarity1
Metal bindingi179MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal phosphate phosphatase PHOSPHO2 (EC:3.1.3.74)
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1920623. Phospho2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688341 – 241Pyridoxal phosphate phosphatase PHOSPHO2Add BLAST241

Proteomic databases

EPDiQ9D9M5.
MaxQBiQ9D9M5.
PaxDbiQ9D9M5.
PeptideAtlasiQ9D9M5.
PRIDEiQ9D9M5.

PTM databases

PhosphoSitePlusiQ9D9M5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027088.
CleanExiMM_PHOSPHO2.
ExpressionAtlasiQ9D9M5. baseline and differential.
GenevisibleiQ9D9M5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028494.

Structurei

3D structure databases

ProteinModelPortaliQ9D9M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3120. Eukaryota.
ENOG4111NAQ. LUCA.
GeneTreeiENSGT00390000007741.
HOGENOMiHOG000231038.
HOVERGENiHBG080058.
InParanoidiQ9D9M5.
KOiK13248.
OMAiDTWVIRC.
OrthoDBiEOG091G0GZ1.
PhylomeDBiQ9D9M5.
TreeFamiTF300112.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006383. HAD-SF_hydro_IB_PSP-like.
IPR016965. Pase_PHOSPHO-typ.
IPR006384. PyrdxlP_Pase-rel.
[Graphical view]
PfamiPF06888. Put_Phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF031051. PyrdxlP_Pase_PHOSPHO2. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01489. DKMTPPase-SF. 1 hit.
TIGR01488. HAD-SF-IB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D9M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLLVFDFD NTIIDDNSDT WIVQCAPDKK LPIELQDSYQ KGLWTEFMGR
60 70 80 90 100
VFKYLRDEGV KADELKRAVT SLPFTSGMIE LLSFLRMNKD RFDCIIISDS
110 120 130 140 150
NSIFIDWVLE AAAFHDVFDH VFTNPASFDS SGRLTVKNYH AHSCTRCPKN
160 170 180 190 200
LCKNTVLGEF IDKQLQKGVR YTRIVYIGDG GNDVCPVTFL KKNDVAMPRE
210 220 230 240
GYTLHRTLAK MSQNLEPMES SIVVWSSGVE IISHLQFLIK M
Length:241
Mass (Da):27,563
Last modified:June 1, 2001 - v1
Checksum:i9E0036C310AD26BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186P → Q in BAE21125 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006724 mRNA. Translation: BAB24714.1.
AK132362 mRNA. Translation: BAE21125.1.
AK159551 mRNA. Translation: BAE35176.1.
AL845261 Genomic DNA. Translation: CAM16374.1.
BC025612 mRNA. Translation: AAH25612.1.
BC031523 mRNA. Translation: AAH31523.1.
CCDSiCCDS16099.1.
RefSeqiNP_082797.1. NM_028521.2.
XP_006500320.1. XM_006500257.1.
UniGeneiMm.9621.

Genome annotation databases

EnsembliENSMUST00000028494; ENSMUSP00000028494; ENSMUSG00000027088.
ENSMUST00000112266; ENSMUSP00000107885; ENSMUSG00000027088.
ENSMUST00000180290; ENSMUSP00000136471; ENSMUSG00000027088.
GeneIDi73373.
KEGGimmu:73373.
UCSCiuc008jyp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006724 mRNA. Translation: BAB24714.1.
AK132362 mRNA. Translation: BAE21125.1.
AK159551 mRNA. Translation: BAE35176.1.
AL845261 Genomic DNA. Translation: CAM16374.1.
BC025612 mRNA. Translation: AAH25612.1.
BC031523 mRNA. Translation: AAH31523.1.
CCDSiCCDS16099.1.
RefSeqiNP_082797.1. NM_028521.2.
XP_006500320.1. XM_006500257.1.
UniGeneiMm.9621.

3D structure databases

ProteinModelPortaliQ9D9M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028494.

PTM databases

PhosphoSitePlusiQ9D9M5.

Proteomic databases

EPDiQ9D9M5.
MaxQBiQ9D9M5.
PaxDbiQ9D9M5.
PeptideAtlasiQ9D9M5.
PRIDEiQ9D9M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028494; ENSMUSP00000028494; ENSMUSG00000027088.
ENSMUST00000112266; ENSMUSP00000107885; ENSMUSG00000027088.
ENSMUST00000180290; ENSMUSP00000136471; ENSMUSG00000027088.
GeneIDi73373.
KEGGimmu:73373.
UCSCiuc008jyp.1. mouse.

Organism-specific databases

CTDi493911.
MGIiMGI:1920623. Phospho2.

Phylogenomic databases

eggNOGiKOG3120. Eukaryota.
ENOG4111NAQ. LUCA.
GeneTreeiENSGT00390000007741.
HOGENOMiHOG000231038.
HOVERGENiHBG080058.
InParanoidiQ9D9M5.
KOiK13248.
OMAiDTWVIRC.
OrthoDBiEOG091G0GZ1.
PhylomeDBiQ9D9M5.
TreeFamiTF300112.

Miscellaneous databases

PROiQ9D9M5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027088.
CleanExiMM_PHOSPHO2.
ExpressionAtlasiQ9D9M5. baseline and differential.
GenevisibleiQ9D9M5. MM.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006383. HAD-SF_hydro_IB_PSP-like.
IPR016965. Pase_PHOSPHO-typ.
IPR006384. PyrdxlP_Pase-rel.
[Graphical view]
PfamiPF06888. Put_Phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF031051. PyrdxlP_Pase_PHOSPHO2. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01489. DKMTPPase-SF. 1 hit.
TIGR01488. HAD-SF-IB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHOP2_MOUSE
AccessioniPrimary (citable) accession number: Q9D9M5
Secondary accession number(s): A2AR04, Q3V1M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.