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Protein

Cell death regulator Aven

Gene

Aven

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Protects against apoptosis mediated by Apaf-1.By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death regulator Aven
Gene namesi
Name:Aven
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921518. Aven.

Subcellular locationi

GO - Cellular componenti

  • endomembrane system Source: UniProtKB-SubCell
  • intracellular Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Cell death regulator AvenPRO_0000064769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821PhosphoserineCombined sources
Modified residuei84 – 841PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D9K3.
MaxQBiQ9D9K3.
PaxDbiQ9D9K3.
PRIDEiQ9D9K3.

PTM databases

iPTMnetiQ9D9K3.
PhosphoSiteiQ9D9K3.

Miscellaneous databases

PMAP-CutDBQ9D9K3.

Expressioni

Gene expression databases

BgeeiQ9D9K3.
CleanExiMM_AVEN.
ExpressionAtlasiQ9D9K3. baseline and differential.
GenevisibleiQ9D9K3. MM.

Interactioni

Subunit structurei

Binds Apaf-1, BCL-2 and BAD (Bcl-xl).By similarity

Protein-protein interaction databases

BioGridi216619. 1 interaction.
STRINGi10090.ENSMUSP00000003705.

Structurei

3D structure databases

ProteinModelPortaliQ9D9K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 7369Ala/Gly-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IKTA. Eukaryota.
ENOG4111U7Z. LUCA.
GeneTreeiENSGT00390000003299.
HOGENOMiHOG000231429.
HOVERGENiHBG024370.
InParanoidiQ9D9K3.
OMAiWDRYQDI.
OrthoDBiEOG74XS8Q.
TreeFamiTF332067.

Family and domain databases

InterProiIPR026187. Aven.
[Graphical view]
PANTHERiPTHR16524. PTHR16524. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D9K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAERGARGG RGRRGGRERP GGDREPVGAA TALARGGCGD GGGRRGRGRG
60 70 80 90 100
FRRGRGGGGL RGGRWEPGGR GGGASTRVEE DSDSETYGEE NDEQGNFSRR
110 120 130 140 150
KIVSNWDRYQ DTEKEVNGES GESQRGTDFS VLLSSAGDSF SQFRFAEEKE
160 170 180 190 200
WDGETSCPKQ NSALYVDSES LVRALEQLPL AVRLNVASEL IQTTIPLELP
210 220 230 240 250
QVKPRRNDDG KELGMHLRGP ISELRSAAGA CPRSLGRGSL RQSPLEGLQK
260 270 280 290 300
APTPTQSVAD HLEEELDMLL HLDAPVQEEG NISPDQTSRD QEPEKDGQVA
310 320 330 340
QEETGPEKPS VTREKNVEPE QPSTSKNVTE EELEDWLDSM IS
Length:342
Mass (Da):37,195
Last modified:July 27, 2011 - v2
Checksum:i2DF7498FA8670155
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti281 – 2811N → I in BAB24752 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006808 mRNA. Translation: BAB24752.1.
AL691423, AL731840 Genomic DNA. Translation: CAM17844.1.
AL731840, AL691423 Genomic DNA. Translation: CAM25808.1.
CH466519 Genomic DNA. Translation: EDL27845.1.
CCDSiCCDS16557.1.
RefSeqiNP_083120.2. NM_028844.3.
UniGeneiMm.315125.
Mm.436657.

Genome annotation databases

EnsembliENSMUST00000003705; ENSMUSP00000003705; ENSMUSG00000003604.
GeneIDi74268.
KEGGimmu:74268.
UCSCiuc008lpe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006808 mRNA. Translation: BAB24752.1.
AL691423, AL731840 Genomic DNA. Translation: CAM17844.1.
AL731840, AL691423 Genomic DNA. Translation: CAM25808.1.
CH466519 Genomic DNA. Translation: EDL27845.1.
CCDSiCCDS16557.1.
RefSeqiNP_083120.2. NM_028844.3.
UniGeneiMm.315125.
Mm.436657.

3D structure databases

ProteinModelPortaliQ9D9K3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216619. 1 interaction.
STRINGi10090.ENSMUSP00000003705.

PTM databases

iPTMnetiQ9D9K3.
PhosphoSiteiQ9D9K3.

Proteomic databases

EPDiQ9D9K3.
MaxQBiQ9D9K3.
PaxDbiQ9D9K3.
PRIDEiQ9D9K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003705; ENSMUSP00000003705; ENSMUSG00000003604.
GeneIDi74268.
KEGGimmu:74268.
UCSCiuc008lpe.2. mouse.

Organism-specific databases

CTDi57099.
MGIiMGI:1921518. Aven.

Phylogenomic databases

eggNOGiENOG410IKTA. Eukaryota.
ENOG4111U7Z. LUCA.
GeneTreeiENSGT00390000003299.
HOGENOMiHOG000231429.
HOVERGENiHBG024370.
InParanoidiQ9D9K3.
OMAiWDRYQDI.
OrthoDBiEOG74XS8Q.
TreeFamiTF332067.

Miscellaneous databases

ChiTaRSiAven. mouse.
PMAP-CutDBQ9D9K3.
PROiQ9D9K3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D9K3.
CleanExiMM_AVEN.
ExpressionAtlasiQ9D9K3. baseline and differential.
GenevisibleiQ9D9K3. MM.

Family and domain databases

InterProiIPR026187. Aven.
[Graphical view]
PANTHERiPTHR16524. PTHR16524. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82 AND SER-84, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Liver, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiAVEN_MOUSE
AccessioniPrimary (citable) accession number: Q9D9K3
Secondary accession number(s): A2AGL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.