Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 22 member 17

Gene

Slc22a17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: Reactome
  • siderophore transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiR-MMU-917937. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 17
Alternative name(s):
24p3 receptor
Short name:
24p3R
Brain-type organic cation transporter
Lipocalin-2 receptor
Gene namesi
Name:Slc22a17
Synonyms:Boct
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1926225. Slc22a17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20320HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence analysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence analysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Solute carrier family 22 member 17PRO_0000398633Add
BLAST

Proteomic databases

MaxQBiQ9D9E0.
PaxDbiQ9D9E0.
PRIDEiQ9D9E0.

PTM databases

iPTMnetiQ9D9E0.
PhosphoSiteiQ9D9E0.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Expressed from E7 and throughout development.1 Publication

Gene expression databases

BgeeiENSMUSG00000022199.
GenevisibleiQ9D9E0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049676.

Structurei

3D structure databases

ProteinModelPortaliQ9D9E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI7. Eukaryota.
ENOG411129W. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000015298.
HOVERGENiHBG031124.
InParanoidiQ9D9E0.
KOiK08213.
OMAiTRLELCE.
OrthoDBiEOG091G07Y4.
PhylomeDBiQ9D9E0.
TreeFamiTF335753.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D9E0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSARFGRRG IVLLTLGLVG PCGVGGAAAG SSTGIMALRF LLGFLLAGVD
60 70 80 90 100
LGVYLMRLEL CDPTQRLRVA LAGELVGVGG HFLFLGLALV SKDWRFLQRM
110 120 130 140 150
ITAPCILFLF YGWPGLFLES ARWLIVKRQI EEAQSVLRIL AERNRPHGQM
160 170 180 190 200
LGEEAQEALQ ELENTCPLPA TSTFSFASLL NYRNIWKNLL ILGFTNFIAH
210 220 230 240 250
AIRHCYQPVG GGGSPSDFYL CSLLASGTAA LACVFLGVTV DRFGRRGILL
260 270 280 290 300
LSMTLTGIAS LVLLGLWDYL NDAAITTFSV LGLFSSQASA ILSTLLASEV
310 320 330 340 350
IPTTVRGRGL GLIMALGALG GLSCPAQRLH MGHGAFLQHV VLAACALLCI
360 370 380 390 400
LSIMLLPETK RKLLPEVLRD GELCRRPSLL RQPPPNRCDH VPLLATPNPA

L
Length:401
Mass (Da):43,195
Last modified:March 1, 2003 - v2
Checksum:i8E203EC412817502
GO
Isoform 2 (identifier: Q9D9E0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):39,913
Checksum:i44C6A9CEBF13A144
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511L → R in BAA76761 (Ref. 1) Curated
Sequence conflicti160 – 1601Q → H in BAA76761 (Ref. 1) Curated
Sequence conflicti274 – 2741A → G in BAA76761 (Ref. 1) Curated
Sequence conflicti362 – 3632KL → NV in BAA76761 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3535Missing in isoform 2. 1 PublicationVSP_039789Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012808 mRNA. Translation: BAA76761.1.
AK007059 mRNA. Translation: BAB24845.2.
CCDSiCCDS36924.1. [Q9D9E0-1]
RefSeqiNP_067526.2. NM_021551.4. [Q9D9E0-1]
UniGeneiMm.27435.

Genome annotation databases

EnsembliENSMUST00000050772; ENSMUSP00000049676; ENSMUSG00000022199. [Q9D9E0-1]
GeneIDi59049.
KEGGimmu:59049.
UCSCiuc007txk.2. mouse. [Q9D9E0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012808 mRNA. Translation: BAA76761.1.
AK007059 mRNA. Translation: BAB24845.2.
CCDSiCCDS36924.1. [Q9D9E0-1]
RefSeqiNP_067526.2. NM_021551.4. [Q9D9E0-1]
UniGeneiMm.27435.

3D structure databases

ProteinModelPortaliQ9D9E0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049676.

PTM databases

iPTMnetiQ9D9E0.
PhosphoSiteiQ9D9E0.

Proteomic databases

MaxQBiQ9D9E0.
PaxDbiQ9D9E0.
PRIDEiQ9D9E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050772; ENSMUSP00000049676; ENSMUSG00000022199. [Q9D9E0-1]
GeneIDi59049.
KEGGimmu:59049.
UCSCiuc007txk.2. mouse. [Q9D9E0-1]

Organism-specific databases

CTDi51310.
MGIiMGI:1926225. Slc22a17.

Phylogenomic databases

eggNOGiENOG410IRI7. Eukaryota.
ENOG411129W. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000015298.
HOVERGENiHBG031124.
InParanoidiQ9D9E0.
KOiK08213.
OMAiTRLELCE.
OrthoDBiEOG091G07Y4.
PhylomeDBiQ9D9E0.
TreeFamiTF335753.

Enzyme and pathway databases

ReactomeiR-MMU-917937. Iron uptake and transport.

Miscellaneous databases

PROiQ9D9E0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022199.
GenevisibleiQ9D9E0. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AH_MOUSE
AccessioniPrimary (citable) accession number: Q9D9E0
Secondary accession number(s): Q9WTM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.