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Protein

Solute carrier family 22 member 17

Gene

Slc22a17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • iron ion homeostasis Source: UniProtKB-KW
  • siderophore transport Source: UniProtKB

Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

ReactomeiR-MMU-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 17
Alternative name(s):
24p3 receptor
Short name:
24p3R
Brain-type organic cation transporter
Lipocalin-2 receptor
Gene namesi
Name:Slc22a17
Synonyms:Boct
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1926225 Slc22a17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei184 – 203HelicalSequence analysisAdd BLAST20
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986331 – 401Solute carrier family 22 member 17Add BLAST401

Proteomic databases

PaxDbiQ9D9E0
PRIDEiQ9D9E0

PTM databases

iPTMnetiQ9D9E0
PhosphoSitePlusiQ9D9E0

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Expressed from E7 and throughout development.1 Publication

Gene expression databases

BgeeiENSMUSG00000022199
GenevisibleiQ9D9E0 MM

Structurei

3D structure databases

ProteinModelPortaliQ9D9E0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI7 Eukaryota
ENOG411129W LUCA
GeneTreeiENSGT00390000014377
HOGENOMiHOG000015298
HOVERGENiHBG031124
InParanoidiQ9D9E0
KOiK08213
OMAiPSFYWTY
OrthoDBiEOG091G07Y4
PhylomeDBiQ9D9E0
TreeFamiTF335753

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D9E0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSARFGRRG IVLLTLGLVG PCGVGGAAAG SSTGIMALRF LLGFLLAGVD
60 70 80 90 100
LGVYLMRLEL CDPTQRLRVA LAGELVGVGG HFLFLGLALV SKDWRFLQRM
110 120 130 140 150
ITAPCILFLF YGWPGLFLES ARWLIVKRQI EEAQSVLRIL AERNRPHGQM
160 170 180 190 200
LGEEAQEALQ ELENTCPLPA TSTFSFASLL NYRNIWKNLL ILGFTNFIAH
210 220 230 240 250
AIRHCYQPVG GGGSPSDFYL CSLLASGTAA LACVFLGVTV DRFGRRGILL
260 270 280 290 300
LSMTLTGIAS LVLLGLWDYL NDAAITTFSV LGLFSSQASA ILSTLLASEV
310 320 330 340 350
IPTTVRGRGL GLIMALGALG GLSCPAQRLH MGHGAFLQHV VLAACALLCI
360 370 380 390 400
LSIMLLPETK RKLLPEVLRD GELCRRPSLL RQPPPNRCDH VPLLATPNPA

L
Length:401
Mass (Da):43,195
Last modified:March 1, 2003 - v2
Checksum:i8E203EC412817502
GO
Isoform 2 (identifier: Q9D9E0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):39,913
Checksum:i44C6A9CEBF13A144
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51L → R in BAA76761 (Ref. 1) Curated1
Sequence conflicti160Q → H in BAA76761 (Ref. 1) Curated1
Sequence conflicti274A → G in BAA76761 (Ref. 1) Curated1
Sequence conflicti362 – 363KL → NV in BAA76761 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0397891 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012808 mRNA Translation: BAA76761.1
AK007059 mRNA Translation: BAB24845.2
CCDSiCCDS36924.1 [Q9D9E0-1]
RefSeqiNP_067526.2, NM_021551.4 [Q9D9E0-1]
UniGeneiMm.27435

Genome annotation databases

EnsembliENSMUST00000050772; ENSMUSP00000049676; ENSMUSG00000022199 [Q9D9E0-1]
GeneIDi59049
KEGGimmu:59049
UCSCiuc007txk.2 mouse [Q9D9E0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS22AH_MOUSE
AccessioniPrimary (citable) accession number: Q9D9E0
Secondary accession number(s): Q9WTM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health