Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Membrane-anchored junction protein

Gene

Majin

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.1 Publication

Miscellaneous

MAJIN was named after the 'genie in Aladdin's lamp' in Japanese.1 Publication

GO - Molecular functioni

GO - Biological processi

  • meiotic attachment of telomere to nuclear envelope Source: UniProtKB
  • meiotic telomere clustering Source: UniProtKB
  • synapsis Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-anchored junction protein1 Publication
Gene namesi
Name:Majin1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1923913. Majin.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 232NuclearCuratedAdd BLAST232
Transmembranei233 – 251HelicalSequence analysisAdd BLAST19
Topological domaini252 – 256Perinuclear spaceCurated5

Keywords - Cellular componenti

Chromosome, Membrane, Nucleus, Telomere

Pathology & Biotechi

Disruption phenotypei

Mice develop normally, exhibit no overt phenotype, but are infertile (both males and females). Gonads are characterized by the absence of post-meiotic cells. Impaired localization of Terb1 and Terb2 to the nucleus inner membrane.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi140 – 145RKWKRK → AAWAAA: Impaired DNA-binding activity. 1 Publication6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258331 – 256Membrane-anchored junction proteinAdd BLAST256

Proteomic databases

PaxDbiQ9D992.
PRIDEiQ9D992.

PTM databases

iPTMnetiQ9D992.
PhosphoSitePlusiQ9D992.

Expressioni

Tissue specificityi

Specifically expressed in germline tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000024786.
GenevisibleiQ9D992. MM.

Interactioni

Subunit structurei

Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN, TERB1 and TERB2.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the MAJIN family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJYJ. Eukaryota.
ENOG410XTYT. LUCA.
GeneTreeiENSGT00390000007971.
HOGENOMiHOG000111742.
InParanoidiQ9D992.
OMAiPHRAKME.
OrthoDBiEOG091G0ITL.

Family and domain databases

InterProiView protein in InterPro
IPR027816. MAJIN.
PfamiView protein in Pfam
PF15077. MAJIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D992-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLKPFTYPF PETRFLHAGP NVYKFKIRYG NSIRGEEIED KEVIVQELED
60 70 80 90 100
SIRAVLANMD SLQPFVTEHF IVFPYKSKWE RVSHLKFKHG ESILTPYPFV
110 120 130 140 150
FTLYIEMKWF AEDLPSGKPA DDIPLELVLA ETEAEEATMR KWKRKLMEEP
160 170 180 190 200
SSPSRQGPHR AKMETSSEAS SNKKPLKESK RSTDEEAQQE YQDTPASNAI
210 220 230 240 250
AVKEQDAALG HGLQGLVVPP LQHSSPPPPK EPGARGFLGF LSALFPFRYF

FKKSGQ
Length:256
Mass (Da):29,175
Last modified:January 20, 2016 - v2
Checksum:i7980FEB7DB388088
GO
Isoform 2 (identifier: Q9D992-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-181: Missing.

Show »
Length:124
Mass (Da):13,898
Checksum:iDCDCE48E33C7519B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05806450 – 181Missing in isoform 2. Add BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007250 mRNA. Translation: BAB24915.1.
AC127556 Genomic DNA. No translation available.
CCDSiCCDS50364.1. [Q9D992-1]
RefSeqiNP_001159391.1. NM_001165919.1. [Q9D992-1]
XP_006531883.1. XM_006531820.2. [Q9D992-2]
UniGeneiMm.159757.

Genome annotation databases

EnsembliENSMUST00000025699; ENSMUSP00000025699; ENSMUSG00000024786. [Q9D992-2]
ENSMUST00000113528; ENSMUSP00000109156; ENSMUSG00000024786. [Q9D992-1]
ENSMUST00000201785; ENSMUSP00000144388; ENSMUSG00000106972. [Q9D992-1]
ENSMUST00000202532; ENSMUSP00000143822; ENSMUSG00000106972. [Q9D992-2]
GeneIDi622554.
KEGGimmu:622554.
UCSCiuc008ghr.2. mouse. [Q9D992-1]
uc012bhj.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMAJIN_MOUSE
AccessioniPrimary (citable) accession number: Q9D992
Secondary accession number(s): E9Q4N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 20, 2016
Last modified: June 7, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families