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Protein

Host cell factor 2

Gene

Hcfc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Host cell factor 2
Short name:
HCF-2
Alternative name(s):
C2 factor
Gene namesi
Name:Hcfc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915183. Hcfc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190731 – 241Host cell factor 2Add BLAST241

Proteomic databases

EPDiQ9D968.
MaxQBiQ9D968.
PaxDbiQ9D968.
PeptideAtlasiQ9D968.
PRIDEiQ9D968.

Expressioni

Gene expression databases

CleanExiMM_HCFC2.

Interactioni

Subunit structurei

Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020478.

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi131 – 137Combined sources7
Beta strandi139 – 147Combined sources9
Beta strandi159 – 165Combined sources7
Beta strandi178 – 186Combined sources9
Beta strandi188 – 193Combined sources6
Helixi194 – 197Combined sources4
Beta strandi205 – 207Combined sources3
Beta strandi209 – 222Combined sources14
Beta strandi226 – 231Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFTNMR-A127-236[»]
ProteinModelPortaliQ9D968.
SMRiQ9D968.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D968.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 124Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini126 – 238Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4152. Eukaryota.
ENOG410Y5AC. LUCA.
InParanoidiQ9D968.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKNEVDEI CALPATKISR VEVHAAATPF SKETPSNPVA ILKAEQWCDV
60 70 80 90 100
GIFKNNTALV SQFYLLPKGK QSMSKVGNAD VPDYSLLKKQ DLVPGTVYKF
110 120 130 140 150
RVAAINGCGI GPLSKVSEFK TCTPGFPGAP STVRISKNVD GIHLSWEPPT
160 170 180 190 200
SPSGNILEYS AYLAIRTAQM QDNPSQLVFM RIYCGLKTSC TVTAGQLANA
210 220 230 240
HIDYTSRPAI VFRISAKNEK GYGPATQIRW LQGNSKKAPL S
Length:241
Mass (Da):26,178
Last modified:June 1, 2001 - v1
Checksum:iF59F66790D98BD14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007317 mRNA. Translation: BAB24953.1.
UniGeneiMm.127405.
Mm.458243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007317 mRNA. Translation: BAB24953.1.
UniGeneiMm.127405.
Mm.458243.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFTNMR-A127-236[»]
ProteinModelPortaliQ9D968.
SMRiQ9D968.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020478.

Proteomic databases

EPDiQ9D968.
MaxQBiQ9D968.
PaxDbiQ9D968.
PeptideAtlasiQ9D968.
PRIDEiQ9D968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1915183. Hcfc2.

Phylogenomic databases

eggNOGiKOG4152. Eukaryota.
ENOG410Y5AC. LUCA.
InParanoidiQ9D968.

Miscellaneous databases

ChiTaRSiHcfc2. mouse.
EvolutionaryTraceiQ9D968.
PROiQ9D968.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HCFC2.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHCFC2_MOUSE
AccessioniPrimary (citable) accession number: Q9D968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.