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Protein

Glycine amidinotransferase, mitochondrial

Gene

Gatm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development.1 Publication

Catalytic activityi

L-arginine + glycine = L-ornithine + guanidinoacetate.By similarity

Pathwayi: creatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes creatine from L-arginine and glycine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glycine amidinotransferase, mitochondrial (Gatm)
  2. Guanidinoacetate N-methyltransferase (Gamt)
This subpathway is part of the pathway creatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes creatine from L-arginine and glycine, the pathway creatine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei254By similarity1
Active sitei303By similarity1
Active sitei407Amidino-cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-MMU-71288 Creatine metabolism
UniPathwayiUPA00104; UER00579

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine amidinotransferase, mitochondrial (EC:2.1.4.1By similarity)
Alternative name(s):
L-arginine:glycine amidinotransferase
Transamidinase
Gene namesi
Name:Gatm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914342 Gatm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionBy similarityAdd BLAST37
ChainiPRO_000000120738 – 423Glycine amidinotransferase, mitochondrialAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei385N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D964
MaxQBiQ9D964
PaxDbiQ9D964
PeptideAtlasiQ9D964
PRIDEiQ9D964

2D gel databases

REPRODUCTION-2DPAGEIPI00112129

PTM databases

iPTMnetiQ9D964
PhosphoSitePlusiQ9D964
SwissPalmiQ9D964

Expressioni

Tissue specificityi

Expressed in kidney, brain, gonads, uterus, and embryonic head, chest and abdomen. Maternally expressed in the placenta and yolk sac of embryos.1 Publication

Developmental stagei

Expressed in a wide range of extraembryonic and embryonic tissues throughout development. Expressed at relatively low levels in mid-gestation stage embryos, with expression gradually increasing during embryonic development.1 Publication

Gene expression databases

BgeeiENSMUSG00000027199
GenevisibleiQ9D964 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi211934, 2 interactors
IntActiQ9D964, 3 interactors
MINTiQ9D964
STRINGi10090.ENSMUSP00000028624

Structurei

3D structure databases

ProteinModelPortaliQ9D964
SMRiQ9D964
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidinotransferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IFBR Eukaryota
ENOG410Y45M LUCA
GeneTreeiENSGT00390000011613
HOGENOMiHOG000231593
HOVERGENiHBG002492
InParanoidiQ9D964
KOiK00613
OMAiRPCHQID
OrthoDBiEOG091G07LX
PhylomeDBiQ9D964
TreeFamiTF300256

Family and domain databases

InterProiView protein in InterPro
IPR033195 AmidinoTrfase
PANTHERiPTHR10488 PTHR10488, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVRCLRGG SRGAEAVHYI GSRLGGSLTG WVQRTFQSTQ AATASSRNSC
60 70 80 90 100
AAEDKATHPL PKDCPVSSYN EWDPLEEVIV GRAENACVPP FTVEVKANTY
110 120 130 140 150
EKYWPFYQKN GGLYFPKDHL KKAVAEVEEM CNILSMEGVT VRRPDPIDWS
160 170 180 190 200
LKYKTPDFES TGLYSAMPRD ILMVVGNEII EAPMAWRSRF FEYRAYRSII
210 220 230 240 250
KDYFHRGAKW TTAPKPTMAD ELYDQNYPIH SVEDRHKLAA QGKFVTTEFE
260 270 280 290 300
PCFDAADFIR AGRDIFAQRS QVTNYLGIEW MRRHLAPDYR VHIISFKDPN
310 320 330 340 350
PMHIDATFNI IGPGLVLSNP DRPCHQIDLF KKAGWTIVTP PTPVIPDDHP
360 370 380 390 400
LWMSSKWLSM NVLMLDEKRV MVDANEVPIQ KMFEKLGIST IKVNIRNANS
410 420
LGGGFHCWTC DVRRRGTLQS YFD
Length:423
Mass (Da):48,297
Last modified:June 1, 2001 - v1
Checksum:i0B51171DACE140B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172L → M in BAE26862 (PubMed:16141072).Curated1
Sequence conflicti258F → Y in BAE30294 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007325 mRNA Translation: BAB24960.1
AK146052 mRNA Translation: BAE26862.1
AK146111 mRNA Translation: BAE26909.1
AK151313 mRNA Translation: BAE30294.1
AK152069 mRNA Translation: BAE30923.1
AL772253 Genomic DNA Translation: CAM13305.1
CH466519 Genomic DNA Translation: EDL28104.1
BC003879 mRNA Translation: AAH03879.1
AY625267 mRNA Translation: AAT39893.1
CCDSiCCDS16665.1
RefSeqiNP_080237.1, NM_025961.5
UniGeneiMm.29975

Genome annotation databases

EnsembliENSMUST00000028624; ENSMUSP00000028624; ENSMUSG00000027199
ENSMUST00000215775; ENSMUSP00000150264; ENSMUSG00000111138
GeneIDi67092
KEGGimmu:67092
UCSCiuc008maw.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGATM_MOUSE
AccessioniPrimary (citable) accession number: Q9D964
Secondary accession number(s): A2AK36
, Q3U8U4, Q3UAM0, Q3UKD9, Q6IU01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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