Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Envoplakin

Gene

Evpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Envoplakin
Alternative name(s):
210 kDa cornified envelope precursor protein
p210
Gene namesi
Name:Evpl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107507. Evpl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20352035EnvoplakinPRO_0000078148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki1468 – 1468Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei1576 – 15761PhosphoserineCombined sources
Modified residuei1800 – 18001PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9D952.
PaxDbiQ9D952.
PRIDEiQ9D952.

PTM databases

PhosphoSiteiQ9D952.

Expressioni

Gene expression databases

BgeeiQ9D952.
CleanExiMM_EVPL.
GenevisibleiQ9D952. MM.

Interactioni

Subunit structurei

May form a homodimer or a heterodimer with PPL.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199548. 16 interactions.
IntActiQ9D952. 18 interactions.
MINTiMINT-4998099.
STRINGi10090.ENSMUSP00000037850.

Structurei

3D structure databases

ProteinModelPortaliQ9D952.
SMRiQ9D952. Positions 1823-2014.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati229 – 330102SpectrinAdd
BLAST
Repeati1186 – 122742Plectin 1Add
BLAST
Repeati1679 – 171436Plectin 2Add
BLAST
Repeati1819 – 185638Plectin 3Add
BLAST
Repeati1857 – 189438Plectin 4Add
BLAST
Repeati1895 – 193238Plectin 5Add
BLAST
Repeati1933 – 197038Plectin 6Add
BLAST
Repeati1971 – 200838Plectin 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 841841Globular 1Add
BLAST
Regioni12 – 28174 X 4 AA tandem repeats of K-G-S-PAdd
BLAST
Regioni842 – 1674833Central fibrous rod domainAdd
BLAST
Regioni1675 – 2035361Globular 2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili842 – 1664823Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated
Contains 7 plectin repeats.Curated
Contains 1 spectrin repeat.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IQBQ. Eukaryota.
ENOG410XRFQ. LUCA.
GeneTreeiENSGT00760000119163.
HOGENOMiHOG000049180.
HOVERGENiHBG018988.
InParanoidiQ9D952.
KOiK10383.
OMAiSPYEAYK.
OrthoDBiEOG74FF00.
TreeFamiTF342779.

Family and domain databases

Gene3Di3.90.1290.10. 2 hits.
InterProiIPR030460. Envoplakin.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERiPTHR23169:SF7. PTHR23169:SF7. 1 hit.
PfamiPF00681. Plectin. 4 hits.
[Graphical view]
SMARTiSM00250. PLEC. 8 hits.
SM00150. SPEC. 1 hit.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9D952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKGLSKGSQ GKGSPKGSPA KGSPKGSPNK HNRAATQELA LLISRMQANA
60 70 80 90 100
DQVERDILET QKKLQQDRQN GEQNQALQHQ QETGRNLKEA EVLLKDLFLD
110 120 130 140 150
VDKARRLKHP QAEEIEKDIK QLHERVTQEC SEYRALYEKM VLPPDVGPRV
160 170 180 190 200
DWARVLEQKQ NLVREGHYGP GMAELEQQVA EHNILQREIE AYGQQLRTLV
210 220 230 240 250
GPDANTIRNQ YRELLKAASW RRQSLGSLYT HLQGCTKQLS ALADQQGRIL
260 270 280 290 300
QQDWSDLMPD PAGVRREYEH FKQHELLAQE RSINQLEDDA DRMVELGHPA
310 320 330 340 350
IGPIQVHQEA LKMEWQNFLN LCICQESQLQ RVEDYRRFQE EADSVSQTLA
360 370 380 390 400
KLSSNLDTKY GFGTGDSSGS PTELLLQLEA EEKQLAIAER AVGDLQQRSQ
410 420 430 440 450
EVAPLPQRRN PSKQPLHVDS ICDWDSGEVQ LLRGERYTLK DNADPYTWLV
460 470 480 490 500
QGPGGETKSA PAACLCIPAP DPEAVAKASR LATELQTLKQ KLSTEKNRLK
510 520 530 540 550
AAAVEHLQPG QQAPAGSAPA DPQGQTLLSQ MTQLDGDLGQ IERQVLSWAR
560 570 580 590 600
SPLSQSSSLK DLEGRIHSCE GTAQRLQSLG AEKEAAQQEC EAFLSTKPTG
610 620 630 640 650
SAALQLPVVL NSVKNRYNDV QSLCHLYGEK AKAALGLEKQ IQEADRVIQG
660 670 680 690 700
FEAALALEGP VPEGSGALQE RVSELQRQRK ELLQQQACVL GLHRQLKATE
710 720 730 740 750
HACSALQNNF QEFCQDLPRQ QRQVRALTDR YHAVGDQLDL REKIVQDASL
760 770 780 790 800
TYQQLRNSRD NLSSWLEQLP HHRVQPSDGP SQISYKLQAQ KRLIQEILGR
810 820 830 840 850
EQDQATVSRL TRDLQEALQD YELQADTYRC SLEPALAVSA PKRLRVISLQ
860 870 880 890 900
ESIQAQEKNL AKAYTEVAAA EQQQLRQLEF AKKMLRKKEL DEDIQAIHSA
910 920 930 940 950
RQGSGSPAHA RTAESEVLKT QLEEERKRVA EVQRDLEEQR QRLLQLRTQQ
960 970 980 990 1000
PVARLEEKEV VEFYRDPQLE SNLSQAASRV EEEGKRRARL QAELEAVAQK
1010 1020 1030 1040 1050
VVHLEGKRKT MQPHLLTKEV TQIERDPGLD SQVTQLHSEM QRLRGENGVL
1060 1070 1080 1090 1100
TARLEELKDE LLALEQKEMN VKEKVVVKEV VKVEKDLEMV KAAQTLRLQI
1110 1120 1130 1140 1150
EEDAARRKGA KETVAKIQAR IKDLEQAISS VEPKVIVKEV KKVEQDPGLL
1160 1170 1180 1190 1200
KEASRLRSLL EEEKNNNVAL ARELQELQEK YRVVEKQKPK VQLQERVSEI
1210 1220 1230 1240 1250
FQVLPETEQE IRRLRAQLQE TGSKKSGVEQ EVEKLLPELE VLRAQKPVVE
1260 1270 1280 1290 1300
YKEVTQEVVR HEKNPEVLRE IDRLKAQLNE LVNTNGRSQE QLIRLQGERD
1310 1320 1330 1340 1350
EWKRERSKVE TKMVSKEVVR HEKDPVLEKE AERLRQEVRE AVQRRRATED
1360 1370 1380 1390 1400
AVYELQNKLL LLERRRPEEQ IVVQEVVVTQ KDPKLREEHS RLSRSLDEEV
1410 1420 1430 1440 1450
GRRRQLELEV RQLGARVEEE EARLSFEEDR SKKLAAEREL RQLTLKIQEL
1460 1470 1480 1490 1500
EKRPPALQEK IIMEEVVKLE KDPDLERSTE ALRRELDQEK NRVTELHREC
1510 1520 1530 1540 1550
QGLQVQVDLL QKTKSQEKTI YKEVIRVEKD PVLEGERARV WEILNRERAA
1560 1570 1580 1590 1600
RKGREEDVRS LQERIDRAEA LRRSWSREEA ELQRARDQAS QDCGRLQRQL
1610 1620 1630 1640 1650
RELEQQKQQK ARQLQEEGRL LSQKTESERQ KAAQRSQAVT QLEAAILQEK
1660 1670 1680 1690 1700
DKIYEKERTL RDLHTKVSRE ELNQETQTRE TNLSTKICIL EPETGNDMSP
1710 1720 1730 1740 1750
YEAYKRGVID RGQYLQLQEL ECDWEEVTTS SPCGEESVLL DRKSGKQYSI
1760 1770 1780 1790 1800
EAALRCRRIS KEEYHRYKDG RLPISEFALL VAGETKPSSS LSIGSIISKS
1810 1820 1830 1840 1850
PVCSPGPQST GFFSPGLSFG LTEDSFPIAG IYDTTTDNKC SIKAAVAKNM
1860 1870 1880 1890 1900
LDPITGQKLL EAQAATGGIV DLLSRERYSV HKAVERGLIE NTSTQRLLNA
1910 1920 1930 1940 1950
QKAFTGIEDP VTRKRLSVGE AIQKGWMPQE SVLPHLLVQH LTGGLIDPKR
1960 1970 1980 1990 2000
TGRIPVPQAV LCGMISEDLG QLLQDESGYE KDLTDPITKE RLSYKEAMGR
2010 2020 2030
CRKDPLSGLL LLPAMLEGYR CYRAASPTLP RSCVR
Length:2,035
Mass (Da):232,012
Last modified:July 27, 2011 - v3
Checksum:i92CD7FB7DE50ECC6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti282 – 2821S → N in CAC38864 (PubMed:10747979).Curated
Sequence conflicti437 – 4371Y → C in CAC38864 (PubMed:10747979).Curated
Sequence conflicti466 – 4661C → W in CAC38864 (PubMed:10747979).Curated
Sequence conflicti476 – 4761A → G in CAC38864 (PubMed:10747979).Curated
Sequence conflicti604 – 6041L → V in CAC38864 (PubMed:10747979).Curated
Sequence conflicti610 – 6112LN → FH in CAC38864 (PubMed:10747979).Curated
Sequence conflicti843 – 8431R → E in CAC38864 (PubMed:10747979).Curated
Sequence conflicti852 – 8521S → N in CAC38864 (PubMed:10747979).Curated
Sequence conflicti858 – 8581K → N in CAC38864 (PubMed:10747979).Curated
Sequence conflicti1013 – 10131P → L in CAC38864 (PubMed:10747979).Curated
Sequence conflicti1635 – 16351R → W in CAC38864 (PubMed:10747979).Curated
Sequence conflicti1830 – 18323GIY → EIF in CAC38864 (PubMed:10747979).Curated
Sequence conflicti1861 – 18644EAQA → RPRQ in CAC38864 (PubMed:10747979).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ309317
, AJ319607, AJ319608, AJ319609, AJ319610, AJ319611, AJ319612, AJ319613 Genomic DNA. Translation: CAC38864.2.
AL669925 Genomic DNA. Translation: CAM16385.1.
AK007353 mRNA. No translation available.
CCDSiCCDS25661.1.
RefSeqiNP_079552.3. NM_025276.3.
UniGeneiMm.293683.

Genome annotation databases

EnsembliENSMUST00000037007; ENSMUSP00000037850; ENSMUSG00000034282.
GeneIDi14027.
KEGGimmu:14027.
UCSCiuc007mkp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ309317
, AJ319607, AJ319608, AJ319609, AJ319610, AJ319611, AJ319612, AJ319613 Genomic DNA. Translation: CAC38864.2.
AL669925 Genomic DNA. Translation: CAM16385.1.
AK007353 mRNA. No translation available.
CCDSiCCDS25661.1.
RefSeqiNP_079552.3. NM_025276.3.
UniGeneiMm.293683.

3D structure databases

ProteinModelPortaliQ9D952.
SMRiQ9D952. Positions 1823-2014.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199548. 16 interactions.
IntActiQ9D952. 18 interactions.
MINTiMINT-4998099.
STRINGi10090.ENSMUSP00000037850.

PTM databases

PhosphoSiteiQ9D952.

Proteomic databases

MaxQBiQ9D952.
PaxDbiQ9D952.
PRIDEiQ9D952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037007; ENSMUSP00000037850; ENSMUSG00000034282.
GeneIDi14027.
KEGGimmu:14027.
UCSCiuc007mkp.1. mouse.

Organism-specific databases

CTDi2125.
MGIiMGI:107507. Evpl.

Phylogenomic databases

eggNOGiENOG410IQBQ. Eukaryota.
ENOG410XRFQ. LUCA.
GeneTreeiENSGT00760000119163.
HOGENOMiHOG000049180.
HOVERGENiHBG018988.
InParanoidiQ9D952.
KOiK10383.
OMAiSPYEAYK.
OrthoDBiEOG74FF00.
TreeFamiTF342779.

Miscellaneous databases

ChiTaRSiEvpl. mouse.
NextBioi284952.
PROiQ9D952.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D952.
CleanExiMM_EVPL.
GenevisibleiQ9D952. MM.

Family and domain databases

Gene3Di3.90.1290.10. 2 hits.
InterProiIPR030460. Envoplakin.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERiPTHR23169:SF7. PTHR23169:SF7. 1 hit.
PfamiPF00681. Plectin. 4 hits.
[Graphical view]
SMARTiSM00250. PLEC. 8 hits.
SM00150. SPEC. 1 hit.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and regulation of the envoplakin gene."
    Maatta A., Ruhrberg C., Watt F.M.
    J. Biol. Chem. 275:19857-19865(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1860-2035.
    Strain: C57BL/6J.
    Tissue: Pancreas.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1576, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiEVPL_MOUSE
AccessioniPrimary (citable) accession number: Q9D952
Secondary accession number(s): B1AU57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: April 13, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.