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Protein

Lysozyme-like protein 4

Gene

Lyzl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in fertilization (PubMed:21444326). Has no detectable bacteriolytic in vitro (PubMed:21444326). Has no lysozyme activity in vitro (By similarity).By similarity1 Publication

Caution

Although it belongs to the glycosyl hydrolase 22 family, Gly-72 is present instead of the conserved Asp which is an active site residue. It is therefore expected that this protein lacks hydrolase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cell wall macromolecule catabolic process Source: GO_Central
  • fertilization Source: UniProtKB
  • single fertilization Source: UniProtKB-KW

Keywordsi

Biological processFertilization

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme-like protein 4
Short name:
Lysozyme-4
Gene namesi
Name:Lyzl4
Synonyms:Lyc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916282 Lyzl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasmic vesicle, Flagellum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024063920 – 145Lysozyme-like protein 4Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 143PROSITE-ProRule annotation
Disulfide bondi49 ↔ 130PROSITE-ProRule annotation
Disulfide bondi84 ↔ 95PROSITE-ProRule annotation
Disulfide bondi91 ↔ 109PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9D925
PRIDEiQ9D925

PTM databases

PhosphoSitePlusiQ9D925

Expressioni

Tissue specificityi

Expressed strongly in testis and in epididymis, and weakly in brain and lung (PubMed:21444326, PubMed:24013621). Detected in sperm (at protein level) (PubMed:21444326).2 Publications

Developmental stagei

No expression in the testis of 2-weeks-old neonates, the expression reaches a peak level at 12 weeks. After that, the level gradually decreases as the age increases (PubMed:21444326, PubMed:24013621).2 Publications

Gene expression databases

BgeeiENSMUSG00000032530
CleanExiMM_LYZL4
ExpressionAtlasiQ9D925 baseline and differential
GenevisibleiQ9D925 MM

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076887

Structurei

3D structure databases

ProteinModelPortaliQ9D925
SMRiQ9D925
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0QX Eukaryota
ENOG410ZG9G LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiQ9D925
OMAiYGLFQIR
OrthoDBiEOG091G0R9V
PhylomeDBiQ9D925
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030062 LYZL4
PANTHERiPTHR11407:SF21 PTHR11407:SF21, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLYLVLLLI SYLLTPIGAS ILGRCTVAKM LYDGGLNYFE GYSLENWVCL
60 70 80 90 100
AYFESKFNPS AVYEDPQDGS TGFGLFQIRD NEWCGHGKNL CSVSCTALLN
110 120 130 140
PNLKDTIQCA KKIVKGKHGM GAWPIWSKNC QLSDVLDRWL DGCDL
Length:145
Mass (Da):16,198
Last modified:June 27, 2006 - v3
Checksum:i2AC71B4AB7EE96BD
GO

Sequence cautioni

The sequence BAB25023 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007412 mRNA Translation: BAB25023.2 Different initiation.
CCDSiCCDS23632.1
RefSeqiNP_081191.1, NM_026915.2
XP_006512311.1, XM_006512248.2
UniGeneiMm.33351

Genome annotation databases

EnsembliENSMUST00000077706; ENSMUSP00000076887; ENSMUSG00000032530
ENSMUST00000120918; ENSMUSP00000113034; ENSMUSG00000032530
GeneIDi69032
UCSCiuc009sdi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLYZL4_MOUSE
AccessioniPrimary (citable) accession number: Q9D925
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: April 25, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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