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Protein

Lysozyme-like protein 4

Gene

Lyzl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme-like protein 4
Short name:
Lysozyme-4
Gene namesi
Name:Lyzl4
Synonyms:Lyc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916282. Lyzl4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024063920 – 145Lysozyme-like protein 4Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 143PROSITE-ProRule annotation
Disulfide bondi49 ↔ 130PROSITE-ProRule annotation
Disulfide bondi84 ↔ 95PROSITE-ProRule annotation
Disulfide bondi91 ↔ 109PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9D925.
PRIDEiQ9D925.

PTM databases

PhosphoSitePlusiQ9D925.

Expressioni

Tissue specificityi

Expressed in testis and epididymis.

Gene expression databases

BgeeiENSMUSG00000032530.
CleanExiMM_LYZL4.
ExpressionAtlasiQ9D925. baseline and differential.
GenevisibleiQ9D925. MM.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076887.

Structurei

3D structure databases

ProteinModelPortaliQ9D925.
SMRiQ9D925.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0QX. Eukaryota.
ENOG410ZG9G. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ9D925.
OMAiYGLFQIR.
OrthoDBiEOG091G0R9V.
PhylomeDBiQ9D925.
TreeFamiTF324882.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030062. LYZL4.
[Graphical view]
PANTHERiPTHR11407:SF21. PTHR11407:SF21. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLYLVLLLI SYLLTPIGAS ILGRCTVAKM LYDGGLNYFE GYSLENWVCL
60 70 80 90 100
AYFESKFNPS AVYEDPQDGS TGFGLFQIRD NEWCGHGKNL CSVSCTALLN
110 120 130 140
PNLKDTIQCA KKIVKGKHGM GAWPIWSKNC QLSDVLDRWL DGCDL
Length:145
Mass (Da):16,198
Last modified:June 27, 2006 - v3
Checksum:i2AC71B4AB7EE96BD
GO

Sequence cautioni

The sequence BAB25023 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007412 mRNA. Translation: BAB25023.2. Different initiation.
CCDSiCCDS23632.1.
RefSeqiNP_081191.1. NM_026915.2.
XP_006512311.1. XM_006512248.2.
UniGeneiMm.33351.

Genome annotation databases

EnsembliENSMUST00000077706; ENSMUSP00000076887; ENSMUSG00000032530.
ENSMUST00000120918; ENSMUSP00000113034; ENSMUSG00000032530.
GeneIDi69032.
KEGGimmu:69032.
UCSCiuc009sdi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007412 mRNA. Translation: BAB25023.2. Different initiation.
CCDSiCCDS23632.1.
RefSeqiNP_081191.1. NM_026915.2.
XP_006512311.1. XM_006512248.2.
UniGeneiMm.33351.

3D structure databases

ProteinModelPortaliQ9D925.
SMRiQ9D925.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076887.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

PTM databases

PhosphoSitePlusiQ9D925.

Proteomic databases

PaxDbiQ9D925.
PRIDEiQ9D925.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077706; ENSMUSP00000076887; ENSMUSG00000032530.
ENSMUST00000120918; ENSMUSP00000113034; ENSMUSG00000032530.
GeneIDi69032.
KEGGimmu:69032.
UCSCiuc009sdi.1. mouse.

Organism-specific databases

CTDi131375.
MGIiMGI:1916282. Lyzl4.

Phylogenomic databases

eggNOGiENOG410J0QX. Eukaryota.
ENOG410ZG9G. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ9D925.
OMAiYGLFQIR.
OrthoDBiEOG091G0R9V.
PhylomeDBiQ9D925.
TreeFamiTF324882.

Miscellaneous databases

PROiQ9D925.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032530.
CleanExiMM_LYZL4.
ExpressionAtlasiQ9D925. baseline and differential.
GenevisibleiQ9D925. MM.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030062. LYZL4.
[Graphical view]
PANTHERiPTHR11407:SF21. PTHR11407:SF21. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYZL4_MOUSE
AccessioniPrimary (citable) accession number: Q9D925
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although it belongs to the glycosyl hydrolase 22 family, Gly-72 is present instead of the conserved Asp which is an active site residue. It is therefore expected that this protein lacks hydrolase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.