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Protein

Iron-sulfur cluster assembly 1 homolog, mitochondrial

Gene

Isca1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571IronBy similarity
Metal bindingi121 – 1211IronBy similarity
Metal bindingi123 – 1231IronBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster assembly 1 homolog, mitochondrial
Alternative name(s):
HESB-like domain-containing protein 2
Iron-sulfur assembly protein IscA
Gene namesi
Name:Isca1
Synonyms:Hbld2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1916296. Isca1.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1212MitochondrionSequence analysisAdd
BLAST
Chaini13 – 129117Iron-sulfur cluster assembly 1 homolog, mitochondrialPRO_0000042736Add
BLAST

Proteomic databases

EPDiQ9D924.
MaxQBiQ9D924.
PaxDbiQ9D924.
PRIDEiQ9D924.

PTM databases

iPTMnetiQ9D924.
PhosphoSiteiQ9D924.

Expressioni

Gene expression databases

BgeeiQ9D924.
GenevisibleiQ9D924. MM.

Interactioni

Subunit structurei

Interacts with CRY2, but not with CRY1 (in vitro).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054858.

Structurei

3D structure databases

ProteinModelPortaliQ9D924.
SMRiQ9D924. Positions 24-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HesB/IscA family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1120. Eukaryota.
COG0316. LUCA.
GeneTreeiENSGT00490000043385.
HOGENOMiHOG000228314.
HOVERGENiHBG081809.
InParanoidiQ9D924.
KOiK13628.
OMAiLAYSVDY.
OrthoDBiEOG780RPV.
PhylomeDBiQ9D924.
TreeFamiTF314956.

Family and domain databases

Gene3Di2.60.300.12. 1 hit.
InterProiIPR000361. FeS_biogenesis.
IPR016092. FeS_cluster_insertion.
IPR017870. FeS_cluster_insertion_CS.
[Graphical view]
PfamiPF01521. Fe-S_biosyn. 1 hit.
[Graphical view]
SUPFAMiSSF89360. SSF89360. 1 hit.
TIGRFAMsiTIGR00049. TIGR00049. 1 hit.
PROSITEiPS01152. HESB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASLVRATV RAVSKRKLQP TRAALTLTPS AVNKIKQLLK DKPEHVGLKV
60 70 80 90 100
GVRTRGCNGL SYSLEYTKTK GDSDEEVIQD GVRVFIEKKA QLTLLGTEMD
110 120
YVEDKLSSEF VFNNPNIKGT CGCGESFHV
Length:129
Mass (Da):14,188
Last modified:June 1, 2001 - v1
Checksum:i3E2133D641688233
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007415 mRNA. Translation: BAB25025.1.
AK045175 mRNA. Translation: BAC32248.1.
AK090000 mRNA. Translation: BAC41037.1.
AK153820 mRNA. Translation: BAE32196.1.
AK169028 mRNA. Translation: BAE40820.1.
AC134869 Genomic DNA. No translation available.
BC018547 mRNA. Translation: AAH18547.1.
BC085482 mRNA. Translation: AAH85482.1.
CCDSiCCDS26578.1.
RefSeqiNP_081197.1. NM_026921.4.
UniGeneiMm.7884.

Genome annotation databases

EnsembliENSMUST00000057115; ENSMUSP00000054858; ENSMUSG00000044792.
GeneIDi69046.
KEGGimmu:69046.
UCSCiuc007qvd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007415 mRNA. Translation: BAB25025.1.
AK045175 mRNA. Translation: BAC32248.1.
AK090000 mRNA. Translation: BAC41037.1.
AK153820 mRNA. Translation: BAE32196.1.
AK169028 mRNA. Translation: BAE40820.1.
AC134869 Genomic DNA. No translation available.
BC018547 mRNA. Translation: AAH18547.1.
BC085482 mRNA. Translation: AAH85482.1.
CCDSiCCDS26578.1.
RefSeqiNP_081197.1. NM_026921.4.
UniGeneiMm.7884.

3D structure databases

ProteinModelPortaliQ9D924.
SMRiQ9D924. Positions 24-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054858.

PTM databases

iPTMnetiQ9D924.
PhosphoSiteiQ9D924.

Proteomic databases

EPDiQ9D924.
MaxQBiQ9D924.
PaxDbiQ9D924.
PRIDEiQ9D924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057115; ENSMUSP00000054858; ENSMUSG00000044792.
GeneIDi69046.
KEGGimmu:69046.
UCSCiuc007qvd.1. mouse.

Organism-specific databases

CTDi81689.
MGIiMGI:1916296. Isca1.

Phylogenomic databases

eggNOGiKOG1120. Eukaryota.
COG0316. LUCA.
GeneTreeiENSGT00490000043385.
HOGENOMiHOG000228314.
HOVERGENiHBG081809.
InParanoidiQ9D924.
KOiK13628.
OMAiLAYSVDY.
OrthoDBiEOG780RPV.
PhylomeDBiQ9D924.
TreeFamiTF314956.

Miscellaneous databases

PROiQ9D924.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D924.
GenevisibleiQ9D924. MM.

Family and domain databases

Gene3Di2.60.300.12. 1 hit.
InterProiIPR000361. FeS_biogenesis.
IPR016092. FeS_cluster_insertion.
IPR017870. FeS_cluster_insertion_CS.
[Graphical view]
PfamiPF01521. Fe-S_biosyn. 1 hit.
[Graphical view]
SUPFAMiSSF89360. SSF89360. 1 hit.
TIGRFAMsiTIGR00049. TIGR00049. 1 hit.
PROSITEiPS01152. HESB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion, Embryo, Kidney, Pancreas and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiISCA1_MOUSE
AccessioniPrimary (citable) accession number: Q9D924
Secondary accession number(s): Q5SZT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.