Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein C8orf4 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (PubMed:24937306). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C8orf4 homolog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916318. 1810011O10Rik.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication
  • Nucleusnucleolus By similarity
  • Nucleus speckle By similarity

  • Note: Localizes in nucleus speckles in presence of CBY1. Translocates to the nucleus upon cellular stress such as H2O2.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nuclear speck Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice have increased number of myeloid and lymphoid cells on peripheral blood compared to wild type controls. Red blood cells are smal-sized but increased in number. In bone marrow, cells show higher colony forming units.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Protein C8orf4 homologPRO_0000089606Add
BLAST

Proteomic databases

PaxDbiQ9D915.
PRIDEiQ9D915.

PTM databases

iPTMnetiQ9D915.
PhosphoSiteiQ9D915.

Expressioni

Tissue specificityi

Expressed in liver, expression levels decrease in regenerating liver (PubMed:25985737). In bone marrow, expressed in large progenitor-like cells, cells with ring-shaped nuclei and, at lower, levels in hematopietic stem cell-like cells with round nuclei (at protein level) (PubMed:24937306).2 Publications

Gene expression databases

BgeeiQ9D915.
CleanExiMM_1810011O10RIK.
GenevisibleiQ9D915. MM.

Interactioni

Subunit structurei

Monomer. Interacts with NOTCH2 (via ANK repeats), the interaction inhibits the nuclear translocation of NOTCH2 N2ICD. Interacts (C-terminus) with CBY1 (C-terminus), C8orf4 competes with CTNNB1 for the interaction with CBY1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058631.

Structurei

3D structure databases

ProteinModelPortaliQ9D915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXNR. Eukaryota.
ENOG410YPN0. LUCA.
GeneTreeiENSGT00390000003458.
HOGENOMiHOG000111608.
HOVERGENiHBG054954.
InParanoidiQ9D915.
OMAiVANIFEN.
OrthoDBiEOG7ZGX5C.
PhylomeDBiQ9D915.
TreeFamiTF338287.

Family and domain databases

InterProiIPR020282. Avpi1/C8orf4.
[Graphical view]
PfamiPF15063. TC1. 1 hit.
[Graphical view]
ProDomiPD287216. Arg_vasopressin-induced_prot_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9D915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKPSHQAT SMSSSLRVSP SIHGYHFDTA ARKKAVGNIF ENIDQESLQR
60 70 80 90 100
LFRNSGDKKA EERAKIIFAI DQDLEEKTRA LMALKKRTKD KLLQFLKLRK

YSIKVH
Length:106
Mass (Da):12,215
Last modified:June 1, 2001 - v1
Checksum:i46D87C0D259DFDB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007441 mRNA. Translation: BAB25041.1.
BC016562 mRNA. Translation: AAH16562.1.
CCDSiCCDS22194.1.
RefSeqiNP_081207.1. NM_026931.2.
UniGeneiMm.25775.

Genome annotation databases

EnsembliENSMUST00000052622; ENSMUSP00000058631; ENSMUSG00000056313.
GeneIDi69068.
KEGGimmu:69068.
UCSCiuc009lex.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007441 mRNA. Translation: BAB25041.1.
BC016562 mRNA. Translation: AAH16562.1.
CCDSiCCDS22194.1.
RefSeqiNP_081207.1. NM_026931.2.
UniGeneiMm.25775.

3D structure databases

ProteinModelPortaliQ9D915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058631.

PTM databases

iPTMnetiQ9D915.
PhosphoSiteiQ9D915.

Proteomic databases

PaxDbiQ9D915.
PRIDEiQ9D915.

Protocols and materials databases

DNASUi69068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052622; ENSMUSP00000058631; ENSMUSG00000056313.
GeneIDi69068.
KEGGimmu:69068.
UCSCiuc009lex.1. mouse.

Organism-specific databases

MGIiMGI:1916318. 1810011O10Rik.

Phylogenomic databases

eggNOGiENOG410IXNR. Eukaryota.
ENOG410YPN0. LUCA.
GeneTreeiENSGT00390000003458.
HOGENOMiHOG000111608.
HOVERGENiHBG054954.
InParanoidiQ9D915.
OMAiVANIFEN.
OrthoDBiEOG7ZGX5C.
PhylomeDBiQ9D915.
TreeFamiTF338287.

Miscellaneous databases

PROiQ9D915.

Gene expression databases

BgeeiQ9D915.
CleanExiMM_1810011O10RIK.
GenevisibleiQ9D915. MM.

Family and domain databases

InterProiIPR020282. Avpi1/C8orf4.
[Graphical view]
PfamiPF15063. TC1. 1 hit.
[Graphical view]
ProDomiPD287216. Arg_vasopressin-induced_prot_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129, C57BL/6J and FVB/N.
    Tissue: Mammary tumor.
  3. "TC1(C8orf4) regulates hematopoietic stem/progenitor cells and hematopoiesis."
    Jung Y., Kim M., Soh H., Lee S., Kim J., Park S., Song K., Lee I.
    PLoS ONE 9:E100311-E100311(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling."
    Zhu P., Wang Y., Du Y., He L., Huang G., Zhang G., Yan X., Fan Z.
    Nat. Commun. 6:7122-7122(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCH004_MOUSE
AccessioniPrimary (citable) accession number: Q9D915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.