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Q9D906

- ATG7_MOUSE

UniProt

Q9D906 - ATG7_MOUSE

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Protein

Ubiquitin-like modifier-activating enzyme ATG7

Gene

Atg7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.13 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei567 – 5671Glycyl thioester intermediateCurated

GO - Molecular functioni

  1. Atg12 activating enzyme activity Source: UniProtKB
  2. Atg8 activating enzyme Source: RefGenome
  3. ubiquitin activating enzyme activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. autophagy Source: MGI
  3. cardiac muscle cell development Source: MGI
  4. cellular amino acid metabolic process Source: MGI
  5. cellular response to hyperoxia Source: UniProtKB
  6. cellular response to nitrogen starvation Source: RefGenome
  7. cellular response to starvation Source: UniProtKB
  8. central nervous system neuron axonogenesis Source: MGI
  9. cerebellar Purkinje cell layer development Source: MGI
  10. cerebral cortex development Source: MGI
  11. C-terminal protein lipidation Source: RefGenome
  12. late nucleophagy Source: RefGenome
  13. liver development Source: MGI
  14. macroautophagy Source: RefGenome
  15. membrane organization Source: MGI
  16. mitochondrion degradation Source: RefGenome
  17. mitochondrion organization Source: MGI
  18. negative regulation of apoptotic process Source: MGI
  19. negative stranded viral RNA replication Source: MGI
  20. neurological system process Source: MGI
  21. neuron projection development Source: MGI
  22. organelle organization Source: MGI
  23. piecemeal microautophagy of nucleus Source: RefGenome
  24. positive regulation of apoptotic process Source: UniProtKB
  25. positive regulation of autophagy Source: UniProtKB
  26. positive regulation of macroautophagy Source: Ensembl
  27. positive regulation of mucus secretion Source: MGI
  28. positive regulation of protein catabolic process Source: UniProtKB
  29. positive regulation of protein modification process Source: MGI
  30. post-embryonic development Source: MGI
  31. protein catabolic process Source: MGI
  32. protein lipidation Source: MGI
  33. protein modification by small protein conjugation Source: MGI
  34. protein transport Source: UniProtKB-KW
  35. protein ubiquitination Source: GOC
  36. pyramidal neuron development Source: MGI
  37. regulation of protein ubiquitination Source: MGI
  38. response to starvation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like modifier-activating enzyme ATG7
Alternative name(s):
ATG12-activating enzyme E1 ATG7
Autophagy-related protein 7
Short name:
APG7-like
Short name:
mAGP7
Ubiquitin-activating enzyme E1-like protein
Gene namesi
Name:Atg7
Synonyms:Apg7l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1921494. Atg7.

Subcellular locationi

Cytoplasm By similarity. Preautophagosomal structure By similarity
Note: Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.1 Publication

GO - Cellular componenti

  1. axoneme Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: RefGenome
  4. pre-autophagosomal structure Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Leads to hepatomegaly in liver and accumulation of abnormal organelles in hepatic cells.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi567 – 5671C → S: Instead of the formation of an intermediate complex with a thiol ester bond between ATG7 (E1-like enzyme) and GABARAPL1 (MAP1LC3, GABARAP or GABARAPL; substrates), a stable complex with an O-ester bond is formed. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Ubiquitin-like modifier-activating enzyme ATG7PRO_0000212807Add
BLAST

Post-translational modificationi

Acetylated by EP300.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D906.
PaxDbiQ9D906.
PRIDEiQ9D906.

PTM databases

PhosphoSiteiQ9D906.

Expressioni

Tissue specificityi

Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.1 Publication

Gene expression databases

BgeeiQ9D906.
CleanExiMM_ATG7.
ExpressionAtlasiQ9D906. baseline and differential.
GenevestigatoriQ9D906.

Interactioni

Subunit structurei

Homodimer. Interacts with ATG3, FOXO1 and EP300 acetyltransferase. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Interacts with FOXO1 (By similarity). Forms intermediate conjugates with ATG8 family proteins such as GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, or GABARAPL1. Interacts with ATG12.By similarity3 Publications

Protein-protein interaction databases

BioGridi216602. 6 interactions.
IntActiQ9D906. 2 interactions.
MINTiMINT-4615793.

Structurei

3D structure databases

ProteinModelPortaliQ9D906.
SMRiQ9D906. Positions 9-685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi11 – 133FAP motif

Domaini

The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.By similarity
The N-terminal FAP motif (residues 11 to 13) is essential for the formation of the ATG89-PE and ATG5-ATG12 conjugates.By similarity

Sequence similaritiesi

Belongs to the ATG7 family.Curated

Phylogenomic databases

eggNOGiCOG0476.
GeneTreeiENSGT00390000017509.
HOGENOMiHOG000162379.
HOVERGENiHBG080877.
InParanoidiQ9D906.
KOiK08337.
OrthoDBiEOG7X0VGG.
PhylomeDBiQ9D906.
TreeFamiTF105689.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006285. Atg7.
IPR009036. Molybdenum_cofac_synth_MoeB.
IPR016040. NAD(P)-bd_dom.
IPR000594. ThiF_NAD_FAD-bd.
[Graphical view]
PANTHERiPTHR10953:SF3. PTHR10953:SF3. 1 hit.
PfamiPF00899. ThiF. 1 hit.
[Graphical view]
SUPFAMiSSF69572. SSF69572. 2 hits.
TIGRFAMsiTIGR01381. E1_like_apg7. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D906-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDPGLAKLQ FAPFNSALDV GFWHELTQKK LNEYRLDEAP KDIKGYYYNG
60 70 80 90 100
DSAGLPTRLT LEFSAFDMSA STPAHCCPAM GTLHNTNTLE AFKTADKKLL
110 120 130 140 150
LEQSANEIWE AIKSGAALEN PMLLNKFLLL TFADLKKYHF YYWFCCPALC
160 170 180 190 200
LPESIPLIRG PVSLDQRLSP KQIQALEHAY DDLCRAEGVT ALPYFLFKYD
210 220 230 240 250
DDTVLVSLLK HYSDFFQGQR TKITVGVYDP CNLAQYPGWP LRNFLVLAAH
260 270 280 290 300
RWSGSFQSVE VLCFRDRTMQ GARDVTHSII FEVKLPEMAF SPDCPKAVGW
310 320 330 340 350
EKNQKGGMGP RMVNLSGCMD PKRLAESSVD LNLKLMCWRL VPTLDLDKVV
360 370 380 390 400
SVKCLLLGAG TLGCNVARTL MGWGVRHVTF VDNAKISYSN PVRQPLYEFE
410 420 430 440 450
DCLGGGKPKA LAAAERLQKI FPGVNARGFN MSIPMPGHPV NFSDVTMEQA
460 470 480 490 500
RRDVEQLEQL IDNHDVIFLL MDTRESRWLP TVIAASKRKL VINAALGFDT
510 520 530 540 550
FVVMRHGLKK PKQQGAGDLC PSHLVAPADL GSSLFANIPG YKLGCYFCND
560 570 580 590 600
VVAPGDSTRD RTLDQQCTVS RPGLAVIAGA LAVELMVSVL QHPEGGYAIA
610 620 630 640 650
SSSDDRMNEP PTSLGLVPHQ IRGFLSRFDN VLPVSLAFDK CTACSPKVLD
660 670 680 690
QYEREGFTFL AKVFNSSHSF LEDLTGLTLL HQETQAAEIW DMSDEETV
Length:698
Mass (Da):77,520
Last modified:June 1, 2001 - v1
Checksum:i79D94EA7464C6ADB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221F → L in BAC10416. (PubMed:11890701)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079385 mRNA. Translation: BAC10416.1.
AK007484 mRNA. Translation: BAB25060.1.
AK035604 mRNA. Translation: BAC29122.1.
AK161133 mRNA. Translation: BAE36208.1.
AK170769 mRNA. Translation: BAE42018.1.
AK172272 mRNA. Translation: BAE42917.1.
BC058597 mRNA. Translation: AAH58597.1.
CCDSiCCDS39598.1.
RefSeqiNP_001240646.1. NM_001253717.1.
NP_001240647.1. NM_001253718.1.
NP_083111.1. NM_028835.4.
XP_006506772.1. XM_006506709.1.
XP_006506773.1. XM_006506710.1.
UniGeneiMm.275332.

Genome annotation databases

EnsembliENSMUST00000032457; ENSMUSP00000032457; ENSMUSG00000030314.
ENSMUST00000182793; ENSMUSP00000138137; ENSMUSG00000030314.
ENSMUST00000182902; ENSMUSP00000138651; ENSMUSG00000030314.
GeneIDi74244.
KEGGimmu:74244.
UCSCiuc009dhz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079385 mRNA. Translation: BAC10416.1 .
AK007484 mRNA. Translation: BAB25060.1 .
AK035604 mRNA. Translation: BAC29122.1 .
AK161133 mRNA. Translation: BAE36208.1 .
AK170769 mRNA. Translation: BAE42018.1 .
AK172272 mRNA. Translation: BAE42917.1 .
BC058597 mRNA. Translation: AAH58597.1 .
CCDSi CCDS39598.1.
RefSeqi NP_001240646.1. NM_001253717.1.
NP_001240647.1. NM_001253718.1.
NP_083111.1. NM_028835.4.
XP_006506772.1. XM_006506709.1.
XP_006506773.1. XM_006506710.1.
UniGenei Mm.275332.

3D structure databases

ProteinModelPortali Q9D906.
SMRi Q9D906. Positions 9-685.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 216602. 6 interactions.
IntActi Q9D906. 2 interactions.
MINTi MINT-4615793.

PTM databases

PhosphoSitei Q9D906.

Proteomic databases

MaxQBi Q9D906.
PaxDbi Q9D906.
PRIDEi Q9D906.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032457 ; ENSMUSP00000032457 ; ENSMUSG00000030314 .
ENSMUST00000182793 ; ENSMUSP00000138137 ; ENSMUSG00000030314 .
ENSMUST00000182902 ; ENSMUSP00000138651 ; ENSMUSG00000030314 .
GeneIDi 74244.
KEGGi mmu:74244.
UCSCi uc009dhz.2. mouse.

Organism-specific databases

CTDi 10533.
MGIi MGI:1921494. Atg7.

Phylogenomic databases

eggNOGi COG0476.
GeneTreei ENSGT00390000017509.
HOGENOMi HOG000162379.
HOVERGENi HBG080877.
InParanoidi Q9D906.
KOi K08337.
OrthoDBi EOG7X0VGG.
PhylomeDBi Q9D906.
TreeFami TF105689.

Enzyme and pathway databases

Reactomei REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSi Atg7. mouse.
NextBioi 340222.
PROi Q9D906.
SOURCEi Search...

Gene expression databases

Bgeei Q9D906.
CleanExi MM_ATG7.
ExpressionAtlasi Q9D906. baseline and differential.
Genevestigatori Q9D906.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006285. Atg7.
IPR009036. Molybdenum_cofac_synth_MoeB.
IPR016040. NAD(P)-bd_dom.
IPR000594. ThiF_NAD_FAD-bd.
[Graphical view ]
PANTHERi PTHR10953:SF3. PTHR10953:SF3. 1 hit.
Pfami PF00899. ThiF. 1 hit.
[Graphical view ]
SUPFAMi SSF69572. SSF69572. 2 hits.
TIGRFAMsi TIGR01381. E1_like_apg7. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs."
    Tanida I., Tanida-Miyake E., Nishitani T., Komatsu M., Yamazaki H., Ueno T., Kominami E.
    Biochem. Biophys. Res. Commun. 292:256-262(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN GABARAPL1-ATG7 INTERMEDIATE CONJUGATE FORMATION, TISSUE SPECIFICITY, INTERACTION WITH ATG12, MUTAGENESIS OF CYS-567.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Pancreas, Spleen and Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method."
    Mizushima N., Yoshimori T., Ohsumi Y.
    FEBS Lett. 532:450-454(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATG10 AND ATG12.
  5. "Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8."
    Yu L., Alva A., Su H., Dutt P., Freundt E., Welsh S., Baehrecke E.H., Lenardo M.J.
    Science 304:1500-1502(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice."
    Komatsu M., Waguri S., Ueno T., Iwata J., Murata S., Tanida I., Ezaki J., Mizushima N., Ohsumi Y., Uchiyama Y., Kominami E., Tanaka K., Chiba T.
    J. Cell Biol. 169:425-434(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3."
    Tanida I., Sou Y.S., Minematsu-Ikeguchi N., Ueno T., Kominami E.
    FEBS J. 273:2553-2562(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GABARAPL1.
  8. "Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration."
    Komatsu M., Wang Q.J., Holstein G.R., Friedrich V.L. Jr., Iwata J., Kominami E., Chait B.T., Tanaka K., Yue Z.
    Proc. Natl. Acad. Sci. U.S.A. 104:14489-14494(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation."
    Zhang J., Randall M.S., Loyd M.R., Dorsey F.C., Kundu M., Cleveland J.L., Ney P.A.
    Blood 114:157-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. Cited for: SUBCELLULAR LOCATION.
  11. Cited for: FUNCTION.
  12. "Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis."
    Zhang Y., Goldman S., Baerga R., Zhao Y., Komatsu M., Jin S.
    Proc. Natl. Acad. Sci. U.S.A. 106:19860-19865(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death."
    Radoshevich L., Murrow L., Chen N., Fernandez E., Roy S., Fung C., Debnath J.
    Cell 142:590-600(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes."
    Pattison J.S., Osinska H., Robbins J.
    Circ. Res. 109:151-160(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. Cited for: FUNCTION.
  16. "Lack of intestinal epithelial atg7 affects paneth cell granule formation but does not compromise immune homeostasis in the gut."
    Wittkopf N., Gunther C., Martini E., Waldner M., Amann K.U., Neurath M.F., Becker C.
    Clin. Dev. Immunol. 2012:278059-278059(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress."
    Lee I.H., Kawai Y., Fergusson M.M., Rovira I.I., Bishop A.J., Motoyama N., Cao L., Finkel T.
    Science 336:225-228(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiATG7_MOUSE
AccessioniPrimary (citable) accession number: Q9D906
Secondary accession number(s): Q3TCD9, Q8K4Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3