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Q9D902

- T2EB_MOUSE

UniProt

Q9D902 - T2EB_MOUSE

Protein

General transcription factor IIE subunit 2

Gene

Gtf2e2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi67 – 14781TFIIE betaPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription initiation from RNA polymerase II promoter Source: InterPro

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor IIE subunit 2
    Alternative name(s):
    Transcription initiation factor IIE subunit beta
    Short name:
    TFIIE-beta
    Gene namesi
    Name:Gtf2e2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1915403. Gtf2e2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. transcription factor TFIIE complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292General transcription factor IIE subunit 2PRO_0000211227Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei75 – 751N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9D902.
    PRIDEiQ9D902.

    PTM databases

    PhosphoSiteiQ9D902.

    Expressioni

    Gene expression databases

    BgeeiQ9D902.
    GenevestigatoriQ9D902.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H By similarity. Interacts with ATF7IP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi212686. 9 interactions.
    DIPiDIP-49546N.
    IntActiQ9D902. 4 interactions.
    MINTiMINT-218577.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D902.
    SMRiQ9D902. Positions 67-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi29 – 379Poly-Ser
    Compositional biasi38 – 436Lys-rich (basic)
    Compositional biasi252 – 27221Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Contains 1 TFIIE beta DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG284684.
    GeneTreeiENSGT00390000011749.
    HOGENOMiHOG000008149.
    HOVERGENiHBG009400.
    InParanoidiQ9D902.
    KOiK03137.
    OMAiLGDQIIF.
    OrthoDBiEOG71ZP2B.
    PhylomeDBiQ9D902.
    TreeFamiTF105901.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR016656. TFIIE-bsu.
    IPR003166. TFIIE_bsu_DNA-bd.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF02186. TFIIE_beta. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016398. TFIIE-beta. 1 hit.
    PROSITEiPS51351. TFIIE_BETA_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D902-1 [UniParc]FASTAAdd to Basket

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    MDPSLLRDRE LFKKRALSTP VVEKRAVPSE SPSSSSSKKK KAKVEHGGSS    50
    GSKQNSDHNN GSFNLKALSG SSGYKFGVLA KIVNYMKTRH QRGDTHPLTL 100
    EEILDETQHL DIGLKQKQWL MTEALVNNPK IEVVDGKYAF KPKYNLKDKK 150
    ALLRLLDNHD QRGLGGILLE DIEEGLPNSQ KAVKALGDQI LFVSRPDKKK 200
    ILFFNDKSCQ FSVDEEFQKL WRSVTVDSMD EEKIEEYLKR QGISSMQESG 250
    PKKVASIQRR KKPASQKKRR FKTHNEHLAG VLKDYSDITP GK 292
    Length:292
    Mass (Da):33,047
    Last modified:April 26, 2005 - v2
    Checksum:i4D74B98C7ACBA60B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201P → L in BAB25066. (PubMed:16141072)Curated
    Sequence conflicti80 – 801A → S in BAB25066. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007492 mRNA. Translation: BAB25066.1.
    AK088342 mRNA. Translation: BAC40294.1.
    AK150415 mRNA. Translation: BAE29539.1.
    AK153370 mRNA. Translation: BAE31938.1.
    AK158783 mRNA. Translation: BAE34662.1.
    BC020016 mRNA. Translation: AAH20016.1.
    CCDSiCCDS22236.1.
    RefSeqiNP_001161393.1. NM_001167921.1.
    NP_001161394.1. NM_001167922.1.
    NP_080860.3. NM_026584.3.
    XP_006509249.1. XM_006509186.1.
    XP_006509250.1. XM_006509187.1.
    XP_006509251.1. XM_006509188.1.
    UniGeneiMm.286104.

    Genome annotation databases

    EnsembliENSMUST00000167264; ENSMUSP00000129834; ENSMUSG00000031585.
    ENSMUST00000170705; ENSMUSP00000126284; ENSMUSG00000031585.
    ENSMUST00000171010; ENSMUSP00000132287; ENSMUSG00000031585.
    GeneIDi68153.
    KEGGimmu:68153.
    UCSCiuc009lkh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007492 mRNA. Translation: BAB25066.1 .
    AK088342 mRNA. Translation: BAC40294.1 .
    AK150415 mRNA. Translation: BAE29539.1 .
    AK153370 mRNA. Translation: BAE31938.1 .
    AK158783 mRNA. Translation: BAE34662.1 .
    BC020016 mRNA. Translation: AAH20016.1 .
    CCDSi CCDS22236.1.
    RefSeqi NP_001161393.1. NM_001167921.1.
    NP_001161394.1. NM_001167922.1.
    NP_080860.3. NM_026584.3.
    XP_006509249.1. XM_006509186.1.
    XP_006509250.1. XM_006509187.1.
    XP_006509251.1. XM_006509188.1.
    UniGenei Mm.286104.

    3D structure databases

    ProteinModelPortali Q9D902.
    SMRi Q9D902. Positions 67-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212686. 9 interactions.
    DIPi DIP-49546N.
    IntActi Q9D902. 4 interactions.
    MINTi MINT-218577.

    PTM databases

    PhosphoSitei Q9D902.

    Proteomic databases

    PaxDbi Q9D902.
    PRIDEi Q9D902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000167264 ; ENSMUSP00000129834 ; ENSMUSG00000031585 .
    ENSMUST00000170705 ; ENSMUSP00000126284 ; ENSMUSG00000031585 .
    ENSMUST00000171010 ; ENSMUSP00000132287 ; ENSMUSG00000031585 .
    GeneIDi 68153.
    KEGGi mmu:68153.
    UCSCi uc009lkh.2. mouse.

    Organism-specific databases

    CTDi 2961.
    MGIi MGI:1915403. Gtf2e2.

    Phylogenomic databases

    eggNOGi NOG284684.
    GeneTreei ENSGT00390000011749.
    HOGENOMi HOG000008149.
    HOVERGENi HBG009400.
    InParanoidi Q9D902.
    KOi K03137.
    OMAi LGDQIIF.
    OrthoDBi EOG71ZP2B.
    PhylomeDBi Q9D902.
    TreeFami TF105901.

    Miscellaneous databases

    NextBioi 326546.
    PROi Q9D902.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D902.
    Genevestigatori Q9D902.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR016656. TFIIE-bsu.
    IPR003166. TFIIE_bsu_DNA-bd.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02186. TFIIE_beta. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016398. TFIIE-beta. 1 hit.
    PROSITEi PS51351. TFIIE_BETA_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Pancreas, Thymus and Visual cortex.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiT2EB_MOUSE
    AccessioniPrimary (citable) accession number: Q9D902
    Secondary accession number(s): Q3U5Y7, Q8BTZ2, Q8VE14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3