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Q9D902 (T2EB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor IIE subunit 2
Alternative name(s):
Transcription initiation factor IIE subunit beta
Short name=TFIIE-beta
Gene names
Name:Gtf2e2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase By similarity.

Subunit structure

Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H By similarity. Interacts with ATF7IP By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 TFIIE beta DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292General transcription factor IIE subunit 2
PRO_0000211227

Regions

DNA binding67 – 14781TFIIE beta
Compositional bias29 – 379Poly-Ser
Compositional bias38 – 436Lys-rich (basic)
Compositional bias252 – 27221Arg/Lys-rich (basic)

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue751N6-acetyllysine Ref.3

Experimental info

Sequence conflict201P → L in BAB25066. Ref.1
Sequence conflict801A → S in BAB25066. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9D902 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 4D74B98C7ACBA60B

FASTA29233,047
        10         20         30         40         50         60 
MDPSLLRDRE LFKKRALSTP VVEKRAVPSE SPSSSSSKKK KAKVEHGGSS GSKQNSDHNN 

        70         80         90        100        110        120 
GSFNLKALSG SSGYKFGVLA KIVNYMKTRH QRGDTHPLTL EEILDETQHL DIGLKQKQWL 

       130        140        150        160        170        180 
MTEALVNNPK IEVVDGKYAF KPKYNLKDKK ALLRLLDNHD QRGLGGILLE DIEEGLPNSQ 

       190        200        210        220        230        240 
KAVKALGDQI LFVSRPDKKK ILFFNDKSCQ FSVDEEFQKL WRSVTVDSMD EEKIEEYLKR 

       250        260        270        280        290 
QGISSMQESG PKKVASIQRR KKPASQKKRR FKTHNEHLAG VLKDYSDITP GK 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Bone marrow, Pancreas, Thymus and Visual cortex.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK007492 mRNA. Translation: BAB25066.1.
AK088342 mRNA. Translation: BAC40294.1.
AK150415 mRNA. Translation: BAE29539.1.
AK153370 mRNA. Translation: BAE31938.1.
AK158783 mRNA. Translation: BAE34662.1.
BC020016 mRNA. Translation: AAH20016.1.
CCDSCCDS22236.1.
RefSeqNP_001161393.1. NM_001167921.1.
NP_001161394.1. NM_001167922.1.
NP_080860.3. NM_026584.3.
XP_006509249.1. XM_006509186.1.
XP_006509250.1. XM_006509187.1.
XP_006509251.1. XM_006509188.1.
UniGeneMm.286104.

3D structure databases

ProteinModelPortalQ9D902.
SMRQ9D902. Positions 67-147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212686. 9 interactions.
DIPDIP-49546N.
IntActQ9D902. 4 interactions.
MINTMINT-218577.

PTM databases

PhosphoSiteQ9D902.

Proteomic databases

PaxDbQ9D902.
PRIDEQ9D902.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000167264; ENSMUSP00000129834; ENSMUSG00000031585.
ENSMUST00000170705; ENSMUSP00000126284; ENSMUSG00000031585.
ENSMUST00000171010; ENSMUSP00000132287; ENSMUSG00000031585.
GeneID68153.
KEGGmmu:68153.
UCSCuc009lkh.2. mouse.

Organism-specific databases

CTD2961.
MGIMGI:1915403. Gtf2e2.

Phylogenomic databases

eggNOGNOG284684.
GeneTreeENSGT00390000011749.
HOGENOMHOG000008149.
HOVERGENHBG009400.
InParanoidQ9D902.
KOK03137.
OMALGDQIIF.
OrthoDBEOG71ZP2B.
PhylomeDBQ9D902.
TreeFamTF105901.

Gene expression databases

BgeeQ9D902.
GenevestigatorQ9D902.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR016656. TFIIE-bsu.
IPR003166. TFIIE_bsu_DNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF02186. TFIIE_beta. 1 hit.
[Graphical view]
PIRSFPIRSF016398. TFIIE-beta. 1 hit.
PROSITEPS51351. TFIIE_BETA_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio326546.
PROQ9D902.
SOURCESearch...

Entry information

Entry nameT2EB_MOUSE
AccessionPrimary (citable) accession number: Q9D902
Secondary accession number(s): Q3U5Y7, Q8BTZ2, Q8VE14
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot