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Protein

General transcription factor IIE subunit 2

Gene

Gtf2e2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi67 – 147TFIIE betaPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6807505. RNA polymerase II transcribes snRNA genes.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIE subunit 2
Alternative name(s):
Transcription initiation factor IIE subunit beta
Short name:
TFIIE-beta
Gene namesi
Name:Gtf2e2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915403. Gtf2e2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112271 – 292General transcription factor IIE subunit 2Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei75N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D902.
MaxQBiQ9D902.
PaxDbiQ9D902.
PeptideAtlasiQ9D902.
PRIDEiQ9D902.

PTM databases

iPTMnetiQ9D902.
PhosphoSitePlusiQ9D902.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031585.
ExpressionAtlasiQ9D902. baseline and differential.
GenevisibleiQ9D902. MM.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H (By similarity). Interacts with ATF7IP (By similarity).By similarity

Protein-protein interaction databases

BioGridi212686. 22 interactors.
DIPiDIP-49546N.
IntActiQ9D902. 15 interactors.
MINTiMINT-218577.
STRINGi10090.ENSMUSP00000126284.

Structurei

3D structure databases

ProteinModelPortaliQ9D902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 37Poly-Ser9
Compositional biasi38 – 43Lys-rich (basic)6
Compositional biasi252 – 272Arg/Lys-rich (basic)Add BLAST21

Sequence similaritiesi

Belongs to the TFIIE beta subunit family.Curated

Phylogenomic databases

eggNOGiKOG3095. Eukaryota.
COG5174. LUCA.
GeneTreeiENSGT00390000011749.
HOGENOMiHOG000008149.
HOVERGENiHBG009400.
InParanoidiQ9D902.
KOiK03137.
OMAiQDGDDHP.
OrthoDBiEOG091G0HXJ.
PhylomeDBiQ9D902.
TreeFamiTF105901.

Family and domain databases

CDDicd07977. TFIIE_beta_winged_helix. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR016656. TFIIE-bsu.
IPR003166. TFIIE_bsu_DNA-bd.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF02186. TFIIE_beta. 1 hit.
PIRSFiPIRSF016398. TFIIE-beta. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS51351. TFIIE_BETA_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSLLRDRE LFKKRALSTP VVEKRAVPSE SPSSSSSKKK KAKVEHGGSS
60 70 80 90 100
GSKQNSDHNN GSFNLKALSG SSGYKFGVLA KIVNYMKTRH QRGDTHPLTL
110 120 130 140 150
EEILDETQHL DIGLKQKQWL MTEALVNNPK IEVVDGKYAF KPKYNLKDKK
160 170 180 190 200
ALLRLLDNHD QRGLGGILLE DIEEGLPNSQ KAVKALGDQI LFVSRPDKKK
210 220 230 240 250
ILFFNDKSCQ FSVDEEFQKL WRSVTVDSMD EEKIEEYLKR QGISSMQESG
260 270 280 290
PKKVASIQRR KKPASQKKRR FKTHNEHLAG VLKDYSDITP GK
Length:292
Mass (Da):33,047
Last modified:April 26, 2005 - v2
Checksum:i4D74B98C7ACBA60B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20P → L in BAB25066 (PubMed:16141072).Curated1
Sequence conflicti80A → S in BAB25066 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007492 mRNA. Translation: BAB25066.1.
AK088342 mRNA. Translation: BAC40294.1.
AK150415 mRNA. Translation: BAE29539.1.
AK153370 mRNA. Translation: BAE31938.1.
AK158783 mRNA. Translation: BAE34662.1.
BC020016 mRNA. Translation: AAH20016.1.
CCDSiCCDS22236.1.
RefSeqiNP_001161393.1. NM_001167921.1.
NP_001161394.1. NM_001167922.1.
NP_080860.3. NM_026584.3.
XP_006509249.1. XM_006509186.1.
XP_006509250.1. XM_006509187.1.
XP_006509251.1. XM_006509188.3.
UniGeneiMm.286104.

Genome annotation databases

EnsembliENSMUST00000167264; ENSMUSP00000129834; ENSMUSG00000031585.
ENSMUST00000170705; ENSMUSP00000126284; ENSMUSG00000031585.
ENSMUST00000171010; ENSMUSP00000132287; ENSMUSG00000031585.
GeneIDi68153.
KEGGimmu:68153.
UCSCiuc009lkh.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiT2EB_MOUSE
AccessioniPrimary (citable) accession number: Q9D902
Secondary accession number(s): Q3U5Y7, Q8BTZ2, Q8VE14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 27, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families