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Q9D902

- T2EB_MOUSE

UniProt

Q9D902 - T2EB_MOUSE

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Protein
General transcription factor IIE subunit 2
Gene
Gtf2e2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi67 – 14781TFIIE beta
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription initiation from RNA polymerase II promoter Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIE subunit 2
Alternative name(s):
Transcription initiation factor IIE subunit beta
Short name:
TFIIE-beta
Gene namesi
Name:Gtf2e2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1915403. Gtf2e2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. transcription factor TFIIE complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292General transcription factor IIE subunit 2
PRO_0000211227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei75 – 751N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9D902.
PRIDEiQ9D902.

PTM databases

PhosphoSiteiQ9D902.

Expressioni

Gene expression databases

BgeeiQ9D902.
GenevestigatoriQ9D902.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H By similarity. Interacts with ATF7IP By similarity.

Protein-protein interaction databases

BioGridi212686. 9 interactions.
DIPiDIP-49546N.
IntActiQ9D902. 4 interactions.
MINTiMINT-218577.

Structurei

3D structure databases

ProteinModelPortaliQ9D902.
SMRiQ9D902. Positions 67-147.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 379Poly-Ser
Compositional biasi38 – 436Lys-rich (basic)
Compositional biasi252 – 27221Arg/Lys-rich (basic)
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG284684.
GeneTreeiENSGT00390000011749.
HOGENOMiHOG000008149.
HOVERGENiHBG009400.
InParanoidiQ9D902.
KOiK03137.
OMAiLGDQIIF.
OrthoDBiEOG71ZP2B.
PhylomeDBiQ9D902.
TreeFamiTF105901.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR016656. TFIIE-bsu.
IPR003166. TFIIE_bsu_DNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02186. TFIIE_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF016398. TFIIE-beta. 1 hit.
PROSITEiPS51351. TFIIE_BETA_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D902-1 [UniParc]FASTAAdd to Basket

« Hide

MDPSLLRDRE LFKKRALSTP VVEKRAVPSE SPSSSSSKKK KAKVEHGGSS    50
GSKQNSDHNN GSFNLKALSG SSGYKFGVLA KIVNYMKTRH QRGDTHPLTL 100
EEILDETQHL DIGLKQKQWL MTEALVNNPK IEVVDGKYAF KPKYNLKDKK 150
ALLRLLDNHD QRGLGGILLE DIEEGLPNSQ KAVKALGDQI LFVSRPDKKK 200
ILFFNDKSCQ FSVDEEFQKL WRSVTVDSMD EEKIEEYLKR QGISSMQESG 250
PKKVASIQRR KKPASQKKRR FKTHNEHLAG VLKDYSDITP GK 292
Length:292
Mass (Da):33,047
Last modified:April 26, 2005 - v2
Checksum:i4D74B98C7ACBA60B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201P → L in BAB25066. 1 Publication
Sequence conflicti80 – 801A → S in BAB25066. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007492 mRNA. Translation: BAB25066.1.
AK088342 mRNA. Translation: BAC40294.1.
AK150415 mRNA. Translation: BAE29539.1.
AK153370 mRNA. Translation: BAE31938.1.
AK158783 mRNA. Translation: BAE34662.1.
BC020016 mRNA. Translation: AAH20016.1.
CCDSiCCDS22236.1.
RefSeqiNP_001161393.1. NM_001167921.1.
NP_001161394.1. NM_001167922.1.
NP_080860.3. NM_026584.3.
XP_006509249.1. XM_006509186.1.
XP_006509250.1. XM_006509187.1.
XP_006509251.1. XM_006509188.1.
UniGeneiMm.286104.

Genome annotation databases

EnsembliENSMUST00000167264; ENSMUSP00000129834; ENSMUSG00000031585.
ENSMUST00000170705; ENSMUSP00000126284; ENSMUSG00000031585.
ENSMUST00000171010; ENSMUSP00000132287; ENSMUSG00000031585.
GeneIDi68153.
KEGGimmu:68153.
UCSCiuc009lkh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007492 mRNA. Translation: BAB25066.1 .
AK088342 mRNA. Translation: BAC40294.1 .
AK150415 mRNA. Translation: BAE29539.1 .
AK153370 mRNA. Translation: BAE31938.1 .
AK158783 mRNA. Translation: BAE34662.1 .
BC020016 mRNA. Translation: AAH20016.1 .
CCDSi CCDS22236.1.
RefSeqi NP_001161393.1. NM_001167921.1.
NP_001161394.1. NM_001167922.1.
NP_080860.3. NM_026584.3.
XP_006509249.1. XM_006509186.1.
XP_006509250.1. XM_006509187.1.
XP_006509251.1. XM_006509188.1.
UniGenei Mm.286104.

3D structure databases

ProteinModelPortali Q9D902.
SMRi Q9D902. Positions 67-147.
ModBasei Search...

Protein-protein interaction databases

BioGridi 212686. 9 interactions.
DIPi DIP-49546N.
IntActi Q9D902. 4 interactions.
MINTi MINT-218577.

PTM databases

PhosphoSitei Q9D902.

Proteomic databases

PaxDbi Q9D902.
PRIDEi Q9D902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000167264 ; ENSMUSP00000129834 ; ENSMUSG00000031585 .
ENSMUST00000170705 ; ENSMUSP00000126284 ; ENSMUSG00000031585 .
ENSMUST00000171010 ; ENSMUSP00000132287 ; ENSMUSG00000031585 .
GeneIDi 68153.
KEGGi mmu:68153.
UCSCi uc009lkh.2. mouse.

Organism-specific databases

CTDi 2961.
MGIi MGI:1915403. Gtf2e2.

Phylogenomic databases

eggNOGi NOG284684.
GeneTreei ENSGT00390000011749.
HOGENOMi HOG000008149.
HOVERGENi HBG009400.
InParanoidi Q9D902.
KOi K03137.
OMAi LGDQIIF.
OrthoDBi EOG71ZP2B.
PhylomeDBi Q9D902.
TreeFami TF105901.

Miscellaneous databases

NextBioi 326546.
PROi Q9D902.
SOURCEi Search...

Gene expression databases

Bgeei Q9D902.
Genevestigatori Q9D902.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR016656. TFIIE-bsu.
IPR003166. TFIIE_bsu_DNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF02186. TFIIE_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF016398. TFIIE-beta. 1 hit.
PROSITEi PS51351. TFIIE_BETA_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Pancreas, Thymus and Visual cortex.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiT2EB_MOUSE
AccessioniPrimary (citable) accession number: Q9D902
Secondary accession number(s): Q3U5Y7, Q8BTZ2, Q8VE14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi