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Protein

Autophagy-related protein 101

Gene

Atg101

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 101
Gene namesi
Name:Atg101
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915368 Atg101

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943231 – 218Autophagy-related protein 101Add BLAST218

Proteomic databases

MaxQBiQ9D8Z6
PaxDbiQ9D8Z6
PeptideAtlasiQ9D8Z6
PRIDEiQ9D8Z6

PTM databases

iPTMnetiQ9D8Z6
PhosphoSitePlusiQ9D8Z6

Expressioni

Gene expression databases

BgeeiENSMUSG00000037204
CleanExiMM_9430023L20RIK
GenevisibleiQ9D8Z6 MM

Interactioni

Subunit structurei

Interacts with ATG13. Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D8Z6, 1 interactor
STRINGi10090.ENSMUSP00000045474

Structurei

3D structure databases

ProteinModelPortaliQ9D8Z6
SMRiQ9D8Z6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 156Important for interaction with ATG13By similarity5

Sequence similaritiesi

Belongs to the ATG101 family.Curated

Phylogenomic databases

eggNOGiKOG4493 Eukaryota
ENOG410XP6A LUCA
GeneTreeiENSGT00390000016511
HOGENOMiHOG000008086
InParanoidiQ9D8Z6
KOiK19730
OMAiIDCDFID
OrthoDBiEOG091G076X
PhylomeDBiQ9D8Z6
TreeFamiTF320996

Family and domain databases

InterProiView protein in InterPro
IPR012445 ATG101
PANTHERiPTHR13292 PTHR13292, 1 hit
PfamiView protein in Pfam
PF07855 ATG101, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D8Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV
60 70 80 90 100
GIQDVDCDFI DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL
110 120 130 140 150
EFYQKKKSRW PFSDECIPWE VWTVKVHVVA LATEQERQIC REKVGEKLCE
160 170 180 190 200
KIINIVEVMS RHEYLPKMPT QSEVDNVFDT GLRDVQPYLY KISFQITEAL
210
GTSVTTTMRR LIKDTLAL
Length:218
Mass (Da):25,002
Last modified:June 1, 2001 - v1
Checksum:i41E2844EE3EC3884
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007505 mRNA Translation: BAB25076.1
AK150298 mRNA Translation: BAE29450.1
AK151381 mRNA Translation: BAE30353.1
AK160336 mRNA Translation: BAE35743.1
AK167951 mRNA Translation: BAE39952.1
BC016463 mRNA Translation: AAH16463.1
CCDSiCCDS27849.1
RefSeqiNP_080842.1, NM_026566.2
XP_006521373.1, XM_006521310.3
UniGeneiMm.482360

Genome annotation databases

EnsembliENSMUST00000048393; ENSMUSP00000045474; ENSMUSG00000037204
GeneIDi68118
KEGGimmu:68118
UCSCiuc007xsw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATGA1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health