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Protein

Activating signal cointegrator 1 complex subunit 1

Gene

Ascc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances NF-kappa-B, SRF and AP1 transactivation. May also play a role in the development of neuromuscular junction.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Activating signal cointegrator 1 complex subunit 1
Alternative name(s):
ASC-1 complex subunit p50
Trip4 complex subunit p50
Gene namesi
Name:Ascc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1916340. Ascc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501011 – 356Activating signal cointegrator 1 complex subunit 1Add BLAST356

Proteomic databases

EPDiQ9D8Z1.
MaxQBiQ9D8Z1.
PaxDbiQ9D8Z1.
PeptideAtlasiQ9D8Z1.
PRIDEiQ9D8Z1.

PTM databases

iPTMnetiQ9D8Z1.
PhosphoSitePlusiQ9D8Z1.

Expressioni

Tissue specificityi

Expressed in the spinal cord, brain, paraspinal ganglia, thyroid, and submandibular glands.1 Publication

Developmental stagei

Expressed in 17.5-day-old embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000044475.
GenevisibleiQ9D8Z1. MM.

Interactioni

Subunit structurei

Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3. The ASC-1 complex interacts with ALKBH3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi213222. 2 interactors.
STRINGi10090.ENSMUSP00000052351.

Structurei

3D structure databases

ProteinModelPortaliQ9D8Z1.
SMRiQ9D8Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 119KHPROSITE-ProRule annotationAdd BLAST63

Phylogenomic databases

eggNOGiKOG2814. Eukaryota.
ENOG4111FMP. LUCA.
GeneTreeiENSGT00390000018119.
HOGENOMiHOG000261687.
HOVERGENiHBG050588.
InParanoidiQ9D8Z1.
KOiK18666.
OMAiGLCATDN.
OrthoDBiEOG091G0FGA.
PhylomeDBiQ9D8Z1.
TreeFamiTF314479.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
3.90.1140.10. 1 hit.
InterProiView protein in InterPro
IPR009210. ASCC1.
IPR009097. cNuc_Pdiesterase.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR036612. KH_dom_type_1_sf.
IPR019510. Kinase-A_anchor_nucl_local_sig.
PfamiView protein in Pfam
PF10469. AKAP7_NLS. 1 hit.
PF00013. KH_1. 1 hit.
PIRSFiPIRSF027019. Euk_LigT. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SUPFAMiSSF54791. SSF54791. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D8Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLRPQIVT FDGRNYRKNP IQEKQYQHEE DEDFYPDSME YSDEPCGAYE
60 70 80 90 100
VAQTPHGFRA TVSAPSLLYK HIVGKRGDTK KKIEVETKTS INIPKHGHEG
110 120 130 140 150
EIVITGQHRN GVVSARTRID VLLDTFRRRQ PFTHFLSFFL NEVEVQERFL
160 170 180 190 200
MFQEEVLRKC SKDRGVDSTI FQNPKKLHLT IGMLVLLSEQ EIQQTCEILQ
210 220 230 240 250
RCKEEFINDI SGGRPLEVEM AGIEYMNDDP AMVDVLYAKV HMKDGSNRLQ
260 270 280 290 300
ELVDRVLERF QSLGLIVKEW TSVKLHATVM NTLLRKDPNA EGRYNLYTAD
310 320 330 340 350
GKYIFKERES FDGRNILKTF ENFYFGSLRL NSIHISQRFT VDSFGNYASC

GHVDFS
Length:356
Mass (Da):41,280
Last modified:June 1, 2001 - v1
Checksum:iE3DBC53A80B439AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007519 mRNA. Translation: BAB25087.1.
AK139944 mRNA. Translation: BAE24191.1.
AK171958 mRNA. Translation: BAE42747.1.
BC030905 mRNA. Translation: AAH30905.1.
CCDSiCCDS23870.1.
RefSeqiNP_001186116.1. NM_001199187.2.
NP_081213.1. NM_026937.3.
XP_006514103.1. XM_006514040.3.
UniGeneiMm.155839.

Genome annotation databases

EnsembliENSMUST00000050516; ENSMUSP00000052351; ENSMUSG00000044475.
ENSMUST00000164083; ENSMUSP00000126301; ENSMUSG00000044475.
GeneIDi69090.
KEGGimmu:69090.
UCSCiuc007feh.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiASCC1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8Z1
Secondary accession number(s): Q3TAC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot