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Protein

Activating signal cointegrator 1 complex subunit 1

Gene

Ascc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances NF-kappa-B, SRF and AP1 transactivation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Activating signal cointegrator 1 complex subunit 1
Alternative name(s):
ASC-1 complex subunit p50
Trip4 complex subunit p50
Gene namesi
Name:Ascc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1916340. Ascc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Activating signal cointegrator 1 complex subunit 1PRO_0000050101Add
BLAST

Proteomic databases

EPDiQ9D8Z1.
MaxQBiQ9D8Z1.
PaxDbiQ9D8Z1.
PRIDEiQ9D8Z1.

PTM databases

iPTMnetiQ9D8Z1.
PhosphoSiteiQ9D8Z1.

Expressioni

Gene expression databases

BgeeiQ9D8Z1.
GenevisibleiQ9D8Z1. MM.

Interactioni

Subunit structurei

Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKHB3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi213222. 1 interaction.
STRINGi10090.ENSMUSP00000052351.

Structurei

3D structure databases

ProteinModelPortaliQ9D8Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 11963KHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2814. Eukaryota.
ENOG4111FMP. LUCA.
GeneTreeiENSGT00390000018119.
HOGENOMiHOG000261687.
HOVERGENiHBG050588.
InParanoidiQ9D8Z1.
KOiK18666.
OMAiRCKEEFI.
OrthoDBiEOG7WQ7SJ.
PhylomeDBiQ9D8Z1.
TreeFamiTF314479.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
3.90.1140.10. 1 hit.
InterProiIPR009210. ASCC1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR019510. Kinase-A_anchor_nucl_local_sig.
IPR009097. RNA_ligase/cNuc_Pdiesterase.
[Graphical view]
PfamiPF10469. AKAP7_NLS. 1 hit.
PF00013. KH_1. 1 hit.
[Graphical view]
PIRSFiPIRSF027019. Euk_LigT. 1 hit.
SMARTiSM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D8Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLRPQIVT FDGRNYRKNP IQEKQYQHEE DEDFYPDSME YSDEPCGAYE
60 70 80 90 100
VAQTPHGFRA TVSAPSLLYK HIVGKRGDTK KKIEVETKTS INIPKHGHEG
110 120 130 140 150
EIVITGQHRN GVVSARTRID VLLDTFRRRQ PFTHFLSFFL NEVEVQERFL
160 170 180 190 200
MFQEEVLRKC SKDRGVDSTI FQNPKKLHLT IGMLVLLSEQ EIQQTCEILQ
210 220 230 240 250
RCKEEFINDI SGGRPLEVEM AGIEYMNDDP AMVDVLYAKV HMKDGSNRLQ
260 270 280 290 300
ELVDRVLERF QSLGLIVKEW TSVKLHATVM NTLLRKDPNA EGRYNLYTAD
310 320 330 340 350
GKYIFKERES FDGRNILKTF ENFYFGSLRL NSIHISQRFT VDSFGNYASC

GHVDFS
Length:356
Mass (Da):41,280
Last modified:June 1, 2001 - v1
Checksum:iE3DBC53A80B439AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007519 mRNA. Translation: BAB25087.1.
AK139944 mRNA. Translation: BAE24191.1.
AK171958 mRNA. Translation: BAE42747.1.
BC030905 mRNA. Translation: AAH30905.1.
CCDSiCCDS23870.1.
RefSeqiNP_001186116.1. NM_001199187.2.
NP_081213.1. NM_026937.3.
XP_006514103.1. XM_006514040.2.
UniGeneiMm.155839.

Genome annotation databases

EnsembliENSMUST00000050516; ENSMUSP00000052351; ENSMUSG00000044475.
ENSMUST00000164083; ENSMUSP00000126301; ENSMUSG00000044475.
GeneIDi69090.
KEGGimmu:69090.
UCSCiuc007feh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007519 mRNA. Translation: BAB25087.1.
AK139944 mRNA. Translation: BAE24191.1.
AK171958 mRNA. Translation: BAE42747.1.
BC030905 mRNA. Translation: AAH30905.1.
CCDSiCCDS23870.1.
RefSeqiNP_001186116.1. NM_001199187.2.
NP_081213.1. NM_026937.3.
XP_006514103.1. XM_006514040.2.
UniGeneiMm.155839.

3D structure databases

ProteinModelPortaliQ9D8Z1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213222. 1 interaction.
STRINGi10090.ENSMUSP00000052351.

PTM databases

iPTMnetiQ9D8Z1.
PhosphoSiteiQ9D8Z1.

Proteomic databases

EPDiQ9D8Z1.
MaxQBiQ9D8Z1.
PaxDbiQ9D8Z1.
PRIDEiQ9D8Z1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050516; ENSMUSP00000052351; ENSMUSG00000044475.
ENSMUST00000164083; ENSMUSP00000126301; ENSMUSG00000044475.
GeneIDi69090.
KEGGimmu:69090.
UCSCiuc007feh.2. mouse.

Organism-specific databases

CTDi51008.
MGIiMGI:1916340. Ascc1.

Phylogenomic databases

eggNOGiKOG2814. Eukaryota.
ENOG4111FMP. LUCA.
GeneTreeiENSGT00390000018119.
HOGENOMiHOG000261687.
HOVERGENiHBG050588.
InParanoidiQ9D8Z1.
KOiK18666.
OMAiRCKEEFI.
OrthoDBiEOG7WQ7SJ.
PhylomeDBiQ9D8Z1.
TreeFamiTF314479.

Miscellaneous databases

ChiTaRSiAscc1. mouse.
PROiQ9D8Z1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D8Z1.
GenevisibleiQ9D8Z1. MM.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
3.90.1140.10. 1 hit.
InterProiIPR009210. ASCC1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR019510. Kinase-A_anchor_nucl_local_sig.
IPR009097. RNA_ligase/cNuc_Pdiesterase.
[Graphical view]
PfamiPF10469. AKAP7_NLS. 1 hit.
PF00013. KH_1. 1 hit.
[Graphical view]
PIRSFiPIRSF027019. Euk_LigT. 1 hit.
SMARTiSM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Egg, Pancreas and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiASCC1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8Z1
Secondary accession number(s): Q3TAC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.