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Protein

Tumor necrosis factor alpha-induced protein 8-like protein 2

Gene

Tnfaip8l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.1 Publication

GO - Biological processi

  • innate immune response Source: UniProtKB-KW
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of T cell activation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 2
Short name:
TIPE2
Short name:
TNF alpha-induced protein 8-like protein 2
Short name:
TNFAIP8-like protein 2
Gene namesi
Name:Tnfaip8l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917019. Tnfaip8l2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Multiorgan inflammation, splenomegaly and premature death. Mice are hypersensitive to septic shock.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Tumor necrosis factor alpha-induced protein 8-like protein 2PRO_0000285772Add
BLAST

Proteomic databases

EPDiQ9D8Y7.
MaxQBiQ9D8Y7.
PaxDbiQ9D8Y7.
PRIDEiQ9D8Y7.

PTM databases

PhosphoSiteiQ9D8Y7.

Expressioni

Tissue specificityi

Expressed in thymus, spleen, lymph node and small intestine, but not in liver, heart, muscle, testis, spinal cord or brain. Up-regulated in the spinal cord of mice with experimental autoimmune encephalomyelitis. Constitutively expressed by macrophages, B and T-lymphocytes at various developmental stages.1 Publication

Inductioni

By TNF in fibroblasts.1 Publication

Gene expression databases

BgeeiQ9D8Y7.
GenevisibleiQ9D8Y7. MM.

Interactioni

Subunit structurei

May interact with CASP8; however, such result is unclear.

Binary interactionsi

WithEntry#Exp.IntActNotes
Casp8O891102EBI-1781612,EBI-851690

Protein-protein interaction databases

IntActiQ9D8Y7. 2 interactions.
STRINGi10090.ENSMUSP00000013851.

Structurei

3D structure databases

ProteinModelPortaliQ9D8Y7.
SMRiQ9D8Y7. Positions 31-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity).By similarity

Sequence similaritiesi

Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IGTQ. Eukaryota.
ENOG4111INB. LUCA.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiQ9D8Y7.
OMAiRSGCFGP.
OrthoDBiEOG7P5T2H.
PhylomeDBiQ9D8Y7.
TreeFamiTF323415.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PANTHERiPTHR12757. PTHR12757. 1 hit.
PfamiPF05527. DUF758. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D8Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT
60 70 80 90 100
HSRPKAQRVI KDLIKVAVKV AVLHRSGCFG PGELALATRF RQKLRQGAMT
110 120 130 140 150
ALSFGEVDFT FEAAVLAGLL VECRDILLEL VEHHLTPKSH DRIRHVFDHY
160 170 180
SDPDLLAALY GPDFTQHLGK ICDGLRKLLD EGKL
Length:184
Mass (Da):20,615
Last modified:June 1, 2001 - v1
Checksum:iB72C5E6FDCD592A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548004 mRNA. Translation: AAQ12263.1.
AK007540 mRNA. Translation: BAB25098.1.
BC055879 mRNA. Translation: AAH55879.1.
BC094616 mRNA. Translation: AAH94616.1.
CCDSiCCDS17603.1.
RefSeqiNP_081482.1. NM_027206.2.
XP_006502103.1. XM_006502040.2.
UniGeneiMm.34368.

Genome annotation databases

EnsembliENSMUST00000013851; ENSMUSP00000013851; ENSMUSG00000013707.
GeneIDi69769.
KEGGimmu:69769.
UCSCiuc008qif.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548004 mRNA. Translation: AAQ12263.1.
AK007540 mRNA. Translation: BAB25098.1.
BC055879 mRNA. Translation: AAH55879.1.
BC094616 mRNA. Translation: AAH94616.1.
CCDSiCCDS17603.1.
RefSeqiNP_081482.1. NM_027206.2.
XP_006502103.1. XM_006502040.2.
UniGeneiMm.34368.

3D structure databases

ProteinModelPortaliQ9D8Y7.
SMRiQ9D8Y7. Positions 31-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D8Y7. 2 interactions.
STRINGi10090.ENSMUSP00000013851.

PTM databases

PhosphoSiteiQ9D8Y7.

Proteomic databases

EPDiQ9D8Y7.
MaxQBiQ9D8Y7.
PaxDbiQ9D8Y7.
PRIDEiQ9D8Y7.

Protocols and materials databases

DNASUi69769.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013851; ENSMUSP00000013851; ENSMUSG00000013707.
GeneIDi69769.
KEGGimmu:69769.
UCSCiuc008qif.1. mouse.

Organism-specific databases

CTDi79626.
MGIiMGI:1917019. Tnfaip8l2.

Phylogenomic databases

eggNOGiENOG410IGTQ. Eukaryota.
ENOG4111INB. LUCA.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiQ9D8Y7.
OMAiRSGCFGP.
OrthoDBiEOG7P5T2H.
PhylomeDBiQ9D8Y7.
TreeFamiTF323415.

Miscellaneous databases

NextBioi330292.
PROiQ9D8Y7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D8Y7.
GenevisibleiQ9D8Y7. MM.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PANTHERiPTHR12757. PTHR12757. 1 hit.
PfamiPF05527. DUF758. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis."
    Sun H., Gong S., Carmody R.J., Hilliard A., Li L., Sun J., Kong L., Xu L., Hilliard B., Hu S., Shen H., Yang X., Chen Y.H.
    Cell 133:415-426(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CASP8, INDUCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary tumor and Thymus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiTP8L2_MOUSE
AccessioniPrimary (citable) accession number: Q9D8Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.