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Protein

Transmembrane protein 126A

Gene

Tmem126a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 126A
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913521 Tmem126a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34Mitochondrial matrixSequence analysisAdd BLAST34
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 57Mitochondrial intermembraneSequence analysis2
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 106Mitochondrial matrixSequence analysisAdd BLAST28
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 159Mitochondrial intermembraneSequence analysisAdd BLAST32
Transmembranei160 – 176HelicalSequence analysisAdd BLAST17
Topological domaini177 – 196Mitochondrial matrixSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710001 – 196Transmembrane protein 126AAdd BLAST196

Proteomic databases

EPDiQ9D8Y1
MaxQBiQ9D8Y1
PaxDbiQ9D8Y1
PeptideAtlasiQ9D8Y1
PRIDEiQ9D8Y1
TopDownProteomicsiQ9D8Y1

PTM databases

iPTMnetiQ9D8Y1
PhosphoSitePlusiQ9D8Y1

Expressioni

Tissue specificityi

In the retina, significant levels of expression are detected in the ganglion cell layer, the optic nerve head, the outer plexiform layer, and in the outer ellipsoide length of photoreceptor inner segments.1 Publication

Gene expression databases

BgeeiENSMUSG00000030615
CleanExiMM_TMEM126A
ExpressionAtlasiQ9D8Y1 baseline and differential
GenevisibleiQ9D8Y1 MM

Interactioni

Protein-protein interaction databases

BioGridi211344, 1 interactor
STRINGi10090.ENSMUSP00000032844

Structurei

3D structure databases

ProteinModelPortaliQ9D8Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM126 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFU0 Eukaryota
ENOG4111M3W LUCA
GeneTreeiENSGT00520000055616
HOGENOMiHOG000059536
HOVERGENiHBG055992
InParanoidiQ9D8Y1
KOiK18157
OMAiGNILNYW
OrthoDBiEOG091G0RCO
PhylomeDBiQ9D8Y1
TreeFamiTF327069

Family and domain databases

InterProiView protein in InterPro
IPR009801 TMEM126
PANTHERiPTHR16296 PTHR16296, 1 hit
PfamiView protein in Pfam
PF07114 TMEM126, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D8Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESHKPSTSK DDLILNIISR KIKQLPESDR NLLEYGSAYI GLNAAFGGLI
60 70 80 90 100
ANSLFRRILN VTQARLASSL PMAVIPFLTA NLSYQSLVSL PLSTGDLNCE
110 120 130 140 150
TCTTTRGALV GLVMGGLYPI LLAIPVNGGL AARYESSPLP QRGNIFNYWI
160 170 180 190
TVSKPVFRKM LFPTLLQTVF ASYLGSRQYK LLIKALQLPE PDLEIH
Length:196
Mass (Da):21,539
Last modified:June 1, 2001 - v1
Checksum:i994DF5E2251C5FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007559 mRNA Translation: BAB25107.1
BC023171 mRNA Translation: AAH23171.1
CCDSiCCDS21447.1
RefSeqiNP_079736.1, NM_025460.2
UniGeneiMm.28963

Genome annotation databases

EnsembliENSMUST00000032844; ENSMUSP00000032844; ENSMUSG00000030615
GeneIDi66271
KEGGimmu:66271
UCSCiuc009ihn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiT126A_MOUSE
AccessioniPrimary (citable) accession number: Q9D8Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health