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Protein

Transmembrane protein 126A

Gene

Tmem126a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 126A
Gene namesi
Name:Tmem126a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913521. Tmem126a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Topological domaini56 – 572Mitochondrial intermembraneSequence analysis
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST
Topological domaini79 – 10628Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Topological domaini128 – 15932Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei160 – 17617HelicalSequence analysisAdd
BLAST
Topological domaini177 – 19620Mitochondrial matrixSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Transmembrane protein 126APRO_0000271000Add
BLAST

Proteomic databases

EPDiQ9D8Y1.
MaxQBiQ9D8Y1.
PaxDbiQ9D8Y1.
PRIDEiQ9D8Y1.
TopDownProteomicsiQ9D8Y1.

PTM databases

iPTMnetiQ9D8Y1.
PhosphoSiteiQ9D8Y1.

Expressioni

Tissue specificityi

In the retina, significant levels of expression are detected in the ganglion cell layer, the optic nerve head, the outer plexiform layer, and in the outer ellipsoide length of photoreceptor inner segments.1 Publication

Gene expression databases

BgeeiQ9D8Y1.
CleanExiMM_TMEM126A.
ExpressionAtlasiQ9D8Y1. baseline and differential.
GenevisibleiQ9D8Y1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032844.

Structurei

3D structure databases

ProteinModelPortaliQ9D8Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM126 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFU0. Eukaryota.
ENOG4111M3W. LUCA.
GeneTreeiENSGT00520000055616.
HOGENOMiHOG000059536.
HOVERGENiHBG055992.
InParanoidiQ9D8Y1.
KOiK18157.
OMAiGNILNYW.
PhylomeDBiQ9D8Y1.
TreeFamiTF327069.

Family and domain databases

InterProiIPR009801. TMEM126.
[Graphical view]
PANTHERiPTHR16296. PTHR16296. 1 hit.
PfamiPF07114. DUF1370. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D8Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESHKPSTSK DDLILNIISR KIKQLPESDR NLLEYGSAYI GLNAAFGGLI
60 70 80 90 100
ANSLFRRILN VTQARLASSL PMAVIPFLTA NLSYQSLVSL PLSTGDLNCE
110 120 130 140 150
TCTTTRGALV GLVMGGLYPI LLAIPVNGGL AARYESSPLP QRGNIFNYWI
160 170 180 190
TVSKPVFRKM LFPTLLQTVF ASYLGSRQYK LLIKALQLPE PDLEIH
Length:196
Mass (Da):21,539
Last modified:June 1, 2001 - v1
Checksum:i994DF5E2251C5FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007559 mRNA. Translation: BAB25107.1.
BC023171 mRNA. Translation: AAH23171.1.
CCDSiCCDS21447.1.
RefSeqiNP_079736.1. NM_025460.2.
UniGeneiMm.28963.

Genome annotation databases

EnsembliENSMUST00000032844; ENSMUSP00000032844; ENSMUSG00000030615.
GeneIDi66271.
KEGGimmu:66271.
UCSCiuc009ihn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007559 mRNA. Translation: BAB25107.1.
BC023171 mRNA. Translation: AAH23171.1.
CCDSiCCDS21447.1.
RefSeqiNP_079736.1. NM_025460.2.
UniGeneiMm.28963.

3D structure databases

ProteinModelPortaliQ9D8Y1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032844.

PTM databases

iPTMnetiQ9D8Y1.
PhosphoSiteiQ9D8Y1.

Proteomic databases

EPDiQ9D8Y1.
MaxQBiQ9D8Y1.
PaxDbiQ9D8Y1.
PRIDEiQ9D8Y1.
TopDownProteomicsiQ9D8Y1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032844; ENSMUSP00000032844; ENSMUSG00000030615.
GeneIDi66271.
KEGGimmu:66271.
UCSCiuc009ihn.1. mouse.

Organism-specific databases

CTDi84233.
MGIiMGI:1913521. Tmem126a.

Phylogenomic databases

eggNOGiENOG410IFU0. Eukaryota.
ENOG4111M3W. LUCA.
GeneTreeiENSGT00520000055616.
HOGENOMiHOG000059536.
HOVERGENiHBG055992.
InParanoidiQ9D8Y1.
KOiK18157.
OMAiGNILNYW.
PhylomeDBiQ9D8Y1.
TreeFamiTF327069.

Miscellaneous databases

NextBioi321161.
PROiQ9D8Y1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D8Y1.
CleanExiMM_TMEM126A.
ExpressionAtlasiQ9D8Y1. baseline and differential.
GenevisibleiQ9D8Y1. MM.

Family and domain databases

InterProiIPR009801. TMEM126.
[Graphical view]
PANTHERiPTHR16296. PTHR16296. 1 hit.
PfamiPF07114. DUF1370. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: TISSUE SPECIFICITY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Liver and Pancreas.

Entry informationi

Entry nameiT126A_MOUSE
AccessioniPrimary (citable) accession number: Q9D8Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.