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Protein

EF-hand domain-containing protein D2

Gene

Efhd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi105 – 1161PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi141 – 1522PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: MGI
  • calcium ion binding Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand domain-containing protein D2
Alternative name(s):
Swiprosin-1
Gene namesi
Name:Efhd2
Synonyms:Sws1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106504. Efhd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000736462 – 240EF-hand domain-containing protein D2Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei74PhosphoserineCombined sources1
Modified residuei76PhosphoserineBy similarity1
Modified residuei83PhosphotyrosineCombined sources1
Modified residuei233N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D8Y0.
MaxQBiQ9D8Y0.
PaxDbiQ9D8Y0.
PeptideAtlasiQ9D8Y0.
PRIDEiQ9D8Y0.

2D gel databases

REPRODUCTION-2DPAGEQ9D8Y0.

PTM databases

iPTMnetiQ9D8Y0.
PhosphoSitePlusiQ9D8Y0.

Expressioni

Tissue specificityi

Detected in thymus, kidney, spleen, lung, liver and brain. Highest abundance in brain and lowest in kidney and thymus.1 Publication

Developmental stagei

Expressed throughout B-cell differentiation, with highest expression in immature bone marrow B-cells.1 Publication

Gene expression databases

CleanExiMM_EFHD2.

Interactioni

Subunit structurei

Interacts with CASP9; with inactive form.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D8Y0. 1 interactor.
STRINGi10090.ENSMUSP00000044502.

Structurei

3D structure databases

ProteinModelPortaliQ9D8Y0.
SMRiQ9D8Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 127EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 163EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0041. Eukaryota.
ENOG4111JG9. LUCA.
HOGENOMiHOG000007978.
HOVERGENiHBG051446.
InParanoidiQ9D8Y0.
PhylomeDBiQ9D8Y0.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDELASKL SRRLQMEGEG GEATEQPGLN GAAAAAAAEA PDETAQALGS
60 70 80 90 100
ADDELSAKLL RRADLNQGIG EPQSPSRRVF NPYTEFKEFS RKQIKDMEKM
110 120 130 140 150
FKQYDAGRDG FIDLMELKLM MEKLGAPQTH LGLKSMIQEV DEDFDSKLSF
160 170 180 190 200
REFLLIFRKA AAGELQEDSG LQVLARLSEI DVSTEGVKGA KNFFEAKVQA
210 220 230 240
INVSSRFEEE IKAEQEERKK QAEEVKQRKA AFKELQSTFK
Length:240
Mass (Da):26,791
Last modified:June 1, 2001 - v1
Checksum:iF11E549BFCB2C247
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14L → V in BAB27476 (PubMed:16141072).Curated1
Sequence conflicti172Q → H in BAB27476 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007560 mRNA. Translation: BAB25108.1.
AK011219 mRNA. Translation: BAB27476.1.
CCDSiCCDS18885.1.
UniGeneiMm.395598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007560 mRNA. Translation: BAB25108.1.
AK011219 mRNA. Translation: BAB27476.1.
CCDSiCCDS18885.1.
UniGeneiMm.395598.

3D structure databases

ProteinModelPortaliQ9D8Y0.
SMRiQ9D8Y0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D8Y0. 1 interactor.
STRINGi10090.ENSMUSP00000044502.

PTM databases

iPTMnetiQ9D8Y0.
PhosphoSitePlusiQ9D8Y0.

2D gel databases

REPRODUCTION-2DPAGEQ9D8Y0.

Proteomic databases

EPDiQ9D8Y0.
MaxQBiQ9D8Y0.
PaxDbiQ9D8Y0.
PeptideAtlasiQ9D8Y0.
PRIDEiQ9D8Y0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:106504. Efhd2.

Phylogenomic databases

eggNOGiKOG0041. Eukaryota.
ENOG4111JG9. LUCA.
HOGENOMiHOG000007978.
HOVERGENiHBG051446.
InParanoidiQ9D8Y0.
PhylomeDBiQ9D8Y0.

Miscellaneous databases

PROiQ9D8Y0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_EFHD2.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFHD2_MOUSE
AccessioniPrimary (citable) accession number: Q9D8Y0
Secondary accession number(s): Q9D0P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.