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Protein

Copper homeostasis protein cutC homolog

Gene

Cutc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in copper homeostasis. Can bind one Cu1+ per subunit (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper homeostasis protein cutC homolog
Gene namesi
Name:Cutc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1913638. Cutc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Copper homeostasis protein cutC homologPRO_0000215089Add
BLAST

Proteomic databases

EPDiQ9D8X1.
MaxQBiQ9D8X1.
PaxDbiQ9D8X1.
PRIDEiQ9D8X1.

PTM databases

iPTMnetiQ9D8X1.
PhosphoSiteiQ9D8X1.

Expressioni

Gene expression databases

BgeeiQ9D8X1.
CleanExiMM_CUTC.
ExpressionAtlasiQ9D8X1. baseline and differential.
GenevisibleiQ9D8X1. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107678.

Structurei

3D structure databases

ProteinModelPortaliQ9D8X1.
SMRiQ9D8X1. Positions 23-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CutC family.Curated

Phylogenomic databases

eggNOGiKOG4013. Eukaryota.
COG3142. LUCA.
GeneTreeiENSGT00390000008454.
HOGENOMiHOG000100908.
HOVERGENiHBG051267.
InParanoidiQ9D8X1.
KOiK06201.
OMAiRIELCAG.
PhylomeDBiQ9D8X1.
TreeFamiTF105937.

Family and domain databases

Gene3Di3.20.20.380. 1 hit.
HAMAPiMF_00795. CutC.
InterProiIPR005627. Cu_homeostasis_CutC.
IPR023648. Cu_homeostasis_CutC_dom.
[Graphical view]
PANTHERiPTHR12598. PTHR12598. 1 hit.
PfamiPF03932. CutC. 1 hit.
[Graphical view]
SUPFAMiSSF110395. SSF110395. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D8X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKGASCERK QAWISSGKAG AGNGFLMEVC VDSVESAVNA ERGGAGRIEL
60 70 80 90 100
CSGLLEGGTT PSMGVLQVVK QSVQIPVFVM IRPRGGDFLY SDREVEVMKA
110 120 130 140 150
DIRLAKLYGA DGLVFGALTE DGHIDKELCL SLVALCRPLP VTFHRAFDMV
160 170 180 190 200
HDPMAALETL LTLGFERVLT SGCDSSALEG LPLIKQLIDQ AKGRIVVMPG
210 220 230 240 250
GGITDKNLQR ILEGSGATEF HCSARSSRDS GMKFRNSSVA MGASLAHSEY
260 270
SLKVTDVTKV RTLNAIAKDV LV
Length:272
Mass (Da):29,004
Last modified:June 1, 2001 - v1
Checksum:i7FE099BCDDA2512C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007591 mRNA. Translation: BAB25124.1.
BC026775 mRNA. Translation: AAH26775.1.
CCDSiCCDS50443.1.
RefSeqiNP_001107034.1. NM_001113562.1.
UniGeneiMm.20257.

Genome annotation databases

EnsembliENSMUST00000112047; ENSMUSP00000107678; ENSMUSG00000025193.
GeneIDi66388.
KEGGimmu:66388.
UCSCiuc008hov.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007591 mRNA. Translation: BAB25124.1.
BC026775 mRNA. Translation: AAH26775.1.
CCDSiCCDS50443.1.
RefSeqiNP_001107034.1. NM_001113562.1.
UniGeneiMm.20257.

3D structure databases

ProteinModelPortaliQ9D8X1.
SMRiQ9D8X1. Positions 23-271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107678.

PTM databases

iPTMnetiQ9D8X1.
PhosphoSiteiQ9D8X1.

Proteomic databases

EPDiQ9D8X1.
MaxQBiQ9D8X1.
PaxDbiQ9D8X1.
PRIDEiQ9D8X1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112047; ENSMUSP00000107678; ENSMUSG00000025193.
GeneIDi66388.
KEGGimmu:66388.
UCSCiuc008hov.2. mouse.

Organism-specific databases

CTDi51076.
MGIiMGI:1913638. Cutc.

Phylogenomic databases

eggNOGiKOG4013. Eukaryota.
COG3142. LUCA.
GeneTreeiENSGT00390000008454.
HOGENOMiHOG000100908.
HOVERGENiHBG051267.
InParanoidiQ9D8X1.
KOiK06201.
OMAiRIELCAG.
PhylomeDBiQ9D8X1.
TreeFamiTF105937.

Miscellaneous databases

PROiQ9D8X1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D8X1.
CleanExiMM_CUTC.
ExpressionAtlasiQ9D8X1. baseline and differential.
GenevisibleiQ9D8X1. MM.

Family and domain databases

Gene3Di3.20.20.380. 1 hit.
HAMAPiMF_00795. CutC.
InterProiIPR005627. Cu_homeostasis_CutC.
IPR023648. Cu_homeostasis_CutC_dom.
[Graphical view]
PANTHERiPTHR12598. PTHR12598. 1 hit.
PfamiPF03932. CutC. 1 hit.
[Graphical view]
SUPFAMiSSF110395. SSF110395. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCUTC_MOUSE
AccessioniPrimary (citable) accession number: Q9D8X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.