Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal peptidase complex catalytic subunit SEC11C

Gene

Sec11c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-MMU-422085. Synthesis, secretion, and deacylation of Ghrelin.

Protein family/group databases

MEROPSiS26.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11C (EC:3.4.21.89)
Alternative name(s):
Microsomal signal peptidase 21 kDa subunit
Short name:
SPase 21 kDa subunit
SEC11 homolog C
SEC11-like protein 3
SPC21
Gene namesi
Name:Sec11c
Synonyms:Sec11l3, Spc21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1913536. Sec11c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2827CytoplasmicSequence analysisAdd
BLAST
Transmembranei29 – 4820Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini49 – 192144LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 192191Signal peptidase complex catalytic subunit SEC11CPRO_0000109549Add
BLAST

Proteomic databases

EPDiQ9D8V7.
MaxQBiQ9D8V7.
PaxDbiQ9D8V7.
PeptideAtlasiQ9D8V7.
PRIDEiQ9D8V7.

PTM databases

PhosphoSiteiQ9D8V7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024516.
CleanExiMM_SEC11C.
ExpressionAtlasiQ9D8V7. baseline and differential.
GenevisibleiQ9D8V7. MM.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

IntActiQ9D8V7. 1 interaction.
STRINGi10090.ENSMUSP00000025394.

Structurei

3D structure databases

ProteinModelPortaliQ9D8V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiQ9D8V7.
KOiK13280.
OMAiHREEDIV.
OrthoDBiEOG091G0X3D.
PhylomeDBiQ9D8V7.
TreeFamiTF313648.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAGAVGTH LPTSSLDIFG DLRKMNKRQL YYQVLNFAMI VSSALMIWKG
60 70 80 90 100
LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE
110 120 130 140 150
GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV
160 170 180 190
VGRARGFLPY VGMVTIIMND YPKFKYALLA VMGAYVLLKR ES
Length:192
Mass (Da):21,660
Last modified:January 23, 2007 - v3
Checksum:i6D4650314EB52CF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007641 mRNA. Translation: BAB25156.1.
BC037187 mRNA. Translation: AAH37187.1.
CCDSiCCDS29309.1.
RefSeqiNP_079744.1. NM_025468.2.
UniGeneiMm.27800.

Genome annotation databases

EnsembliENSMUST00000025394; ENSMUSP00000025394; ENSMUSG00000024516.
GeneIDi66286.
KEGGimmu:66286.
UCSCiuc008ffh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007641 mRNA. Translation: BAB25156.1.
BC037187 mRNA. Translation: AAH37187.1.
CCDSiCCDS29309.1.
RefSeqiNP_079744.1. NM_025468.2.
UniGeneiMm.27800.

3D structure databases

ProteinModelPortaliQ9D8V7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D8V7. 1 interaction.
STRINGi10090.ENSMUSP00000025394.

Protein family/group databases

MEROPSiS26.022.

PTM databases

PhosphoSiteiQ9D8V7.

Proteomic databases

EPDiQ9D8V7.
MaxQBiQ9D8V7.
PaxDbiQ9D8V7.
PeptideAtlasiQ9D8V7.
PRIDEiQ9D8V7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025394; ENSMUSP00000025394; ENSMUSG00000024516.
GeneIDi66286.
KEGGimmu:66286.
UCSCiuc008ffh.1. mouse.

Organism-specific databases

CTDi90701.
MGIiMGI:1913536. Sec11c.

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiQ9D8V7.
KOiK13280.
OMAiHREEDIV.
OrthoDBiEOG091G0X3D.
PhylomeDBiQ9D8V7.
TreeFamiTF313648.

Enzyme and pathway databases

ReactomeiR-MMU-422085. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

ChiTaRSiSec11c. mouse.
PROiQ9D8V7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024516.
CleanExiMM_SEC11C.
ExpressionAtlasiQ9D8V7. baseline and differential.
GenevisibleiQ9D8V7. MM.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC11C_MOUSE
AccessioniPrimary (citable) accession number: Q9D8V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.