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Protein

Signal peptidase complex catalytic subunit SEC11C

Gene

Sec11c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

ReactomeiR-MMU-422085. Synthesis, secretion, and deacylation of Ghrelin.

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11C (EC:3.4.21.89)
Alternative name(s):
Microsomal signal peptidase 21 kDa subunit
Short name:
SPase 21 kDa subunit
SEC11 homolog C
SEC11-like protein 3
SPC21
Gene namesi
Name:Sec11c
Synonyms:Sec11l3, Spc21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1913536. Sec11c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini49 – 192LumenalSequence analysisAdd BLAST144

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095491 – 192Signal peptidase complex catalytic subunit SEC11CAdd BLAST192

Proteomic databases

EPDiQ9D8V7.
MaxQBiQ9D8V7.
PaxDbiQ9D8V7.
PeptideAtlasiQ9D8V7.
PRIDEiQ9D8V7.

PTM databases

PhosphoSitePlusiQ9D8V7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024516.
CleanExiMM_SEC11C.
ExpressionAtlasiQ9D8V7. baseline and differential.
GenevisibleiQ9D8V7. MM.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

IntActiQ9D8V7. 1 interactor.
STRINGi10090.ENSMUSP00000025394.

Structurei

3D structure databases

ProteinModelPortaliQ9D8V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiQ9D8V7.
KOiK13280.
OMAiWKGLIVI.
OrthoDBiEOG091G0X3D.
PhylomeDBiQ9D8V7.
TreeFamiTF313648.

Family and domain databases

InterProiView protein in InterPro
IPR036286. LexA/Signal_pep-like_sf.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiView protein in Pfam
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D8V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAGAVGTH LPTSSLDIFG DLRKMNKRQL YYQVLNFAMI VSSALMIWKG
60 70 80 90 100
LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE
110 120 130 140 150
GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV
160 170 180 190
VGRARGFLPY VGMVTIIMND YPKFKYALLA VMGAYVLLKR ES
Length:192
Mass (Da):21,660
Last modified:January 23, 2007 - v3
Checksum:i6D4650314EB52CF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007641 mRNA. Translation: BAB25156.1.
BC037187 mRNA. Translation: AAH37187.1.
CCDSiCCDS29309.1.
RefSeqiNP_079744.1. NM_025468.2.
UniGeneiMm.27800.

Genome annotation databases

EnsembliENSMUST00000025394; ENSMUSP00000025394; ENSMUSG00000024516.
GeneIDi66286.
KEGGimmu:66286.
UCSCiuc008ffh.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSC11C_MOUSE
AccessioniPrimary (citable) accession number: Q9D8V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families