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Protein

Complement C1q tumor necrosis factor-related protein 2

Gene

C1qtnf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

GO - Molecular functioni

  • identical protein binding Source: MGI
  • signaling receptor binding Source: MGI

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • positive regulation of fatty acid oxidation Source: MGI
  • positive regulation of glucose import Source: MGI
  • positive regulation of glycogen biosynthetic process Source: MGI
  • protein heterotrimerization Source: MGI
  • protein homooligomerization Source: MGI
  • protein trimerization Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 2
Short name:
mCTRP2
Gene namesi
Name:C1qtnf2
Synonyms:Crtp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916433 C1qtnf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000032008325 – 294Complement C1q tumor necrosis factor-related protein 2Add BLAST270

Proteomic databases

MaxQBiQ9D8U4
PaxDbiQ9D8U4
PRIDEiQ9D8U4

PTM databases

iPTMnetiQ9D8U4
PhosphoSitePlusiQ9D8U4

Expressioni

Gene expression databases

BgeeiENSMUSG00000046491
CleanExiMM_C1QTNF2
ExpressionAtlasiQ9D8U4 baseline and differential
GenevisibleiQ9D8U4 MM

Interactioni

Subunit structurei

May interact with ERFE.

GO - Molecular functioni

  • identical protein binding Source: MGI
  • signaling receptor binding Source: MGI

Structurei

3D structure databases

ProteinModelPortaliQ9D8U4
SMRiQ9D8U4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 150Collagen-likeAdd BLAST103
Domaini154 – 290C1qPROSITE-ProRule annotationAdd BLAST137

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IEVW Eukaryota
ENOG410XQXK LUCA
GeneTreeiENSGT00760000118830
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiQ9D8U4
PhylomeDBiQ9D8U4
TreeFamiTF329591

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 2 hits
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIFKKVTTM ISWVLLACAL PCAADPMLGA FARRDFQKGG PQLVCSLPGP
60 70 80 90 100
QGPPGPPGAP GSSGVVGRMG FPGKDGQDGQ DGDRGDSGEE GPPGRTGNRG
110 120 130 140 150
KQGPKGKAGA IGRAGPRGPK GVSGTPGKHG TPGKKGPKGK KGEPGLPGPC
160 170 180 190 200
SCGSSRAKSA FSVAVTKSYP RERLPIKFDK ILMNEGGHYN ASSGKFVCSV
210 220 230 240 250
PGIYYFTYDI TLANKHLAIG LVHNGQYRIR TFDANTGNHD VASGSTILAL
260 270 280 290
KEGDEVWLQI FYSEQNGLFY DPYWTDSLFT GFLIYADQGD PNEV
Length:294
Mass (Da):30,865
Last modified:June 1, 2001 - v1
Checksum:i6D3905AE7C19E6FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002395 mRNA Translation: AAY21927.1
AK007683 mRNA Translation: BAB25187.1
AL670472 Genomic DNA No translation available.
BC030324 mRNA Translation: AAH30324.1
CCDSiCCDS24558.1
RefSeqiNP_081255.1, NM_026979.5
UniGeneiMm.390374

Genome annotation databases

EnsembliENSMUST00000057679; ENSMUSP00000051652; ENSMUSG00000046491
GeneIDi69183
KEGGimmu:69183
UCSCiuc007imr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiC1QT2_MOUSE
AccessioniPrimary (citable) accession number: Q9D8U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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