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Protein

Complement C1q tumor necrosis factor-related protein 2

Gene

C1qtnf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • positive regulation of fatty acid oxidation Source: MGI
  • positive regulation of glucose import Source: MGI
  • positive regulation of glycogen biosynthetic process Source: MGI
  • protein heterotrimerization Source: MGI
  • protein homooligomerization Source: MGI
  • protein trimerization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 2
Short name:
mCTRP2
Gene namesi
Name:C1qtnf2
Synonyms:Crtp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916433. C1qtnf2.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 294270Complement C1q tumor necrosis factor-related protein 2PRO_0000320083Add
BLAST

Proteomic databases

MaxQBiQ9D8U4.
PaxDbiQ9D8U4.
PRIDEiQ9D8U4.

PTM databases

iPTMnetiQ9D8U4.
PhosphoSiteiQ9D8U4.

Expressioni

Gene expression databases

BgeeiQ9D8U4.
CleanExiMM_C1QTNF2.
ExpressionAtlasiQ9D8U4. baseline and differential.
GenevisibleiQ9D8U4. MM.

Interactioni

Subunit structurei

May interact with FAM132B.

GO - Molecular functioni

  • identical protein binding Source: MGI
  • receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051652.

Structurei

3D structure databases

ProteinModelPortaliQ9D8U4.
SMRiQ9D8U4. Positions 159-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 150103Collagen-likeAdd
BLAST
Domaini154 – 290137C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IEVW. Eukaryota.
ENOG410XQXK. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ9D8U4.
PhylomeDBiQ9D8U4.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIFKKVTTM ISWVLLACAL PCAADPMLGA FARRDFQKGG PQLVCSLPGP
60 70 80 90 100
QGPPGPPGAP GSSGVVGRMG FPGKDGQDGQ DGDRGDSGEE GPPGRTGNRG
110 120 130 140 150
KQGPKGKAGA IGRAGPRGPK GVSGTPGKHG TPGKKGPKGK KGEPGLPGPC
160 170 180 190 200
SCGSSRAKSA FSVAVTKSYP RERLPIKFDK ILMNEGGHYN ASSGKFVCSV
210 220 230 240 250
PGIYYFTYDI TLANKHLAIG LVHNGQYRIR TFDANTGNHD VASGSTILAL
260 270 280 290
KEGDEVWLQI FYSEQNGLFY DPYWTDSLFT GFLIYADQGD PNEV
Length:294
Mass (Da):30,865
Last modified:June 1, 2001 - v1
Checksum:i6D3905AE7C19E6FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002395 mRNA. Translation: AAY21927.1.
AK007683 mRNA. Translation: BAB25187.1.
AL670472 Genomic DNA. Translation: CAI24828.1.
BC030324 mRNA. Translation: AAH30324.1.
CCDSiCCDS24558.1.
RefSeqiNP_081255.1. NM_026979.5.
XP_006534172.1. XM_006534109.2.
UniGeneiMm.390374.

Genome annotation databases

EnsembliENSMUST00000057679; ENSMUSP00000051652; ENSMUSG00000046491.
GeneIDi69183.
KEGGimmu:69183.
UCSCiuc007imr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002395 mRNA. Translation: AAY21927.1.
AK007683 mRNA. Translation: BAB25187.1.
AL670472 Genomic DNA. Translation: CAI24828.1.
BC030324 mRNA. Translation: AAH30324.1.
CCDSiCCDS24558.1.
RefSeqiNP_081255.1. NM_026979.5.
XP_006534172.1. XM_006534109.2.
UniGeneiMm.390374.

3D structure databases

ProteinModelPortaliQ9D8U4.
SMRiQ9D8U4. Positions 159-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051652.

PTM databases

iPTMnetiQ9D8U4.
PhosphoSiteiQ9D8U4.

Proteomic databases

MaxQBiQ9D8U4.
PaxDbiQ9D8U4.
PRIDEiQ9D8U4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057679; ENSMUSP00000051652; ENSMUSG00000046491.
GeneIDi69183.
KEGGimmu:69183.
UCSCiuc007imr.2. mouse.

Organism-specific databases

CTDi114898.
MGIiMGI:1916433. C1qtnf2.

Phylogenomic databases

eggNOGiENOG410IEVW. Eukaryota.
ENOG410XQXK. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ9D8U4.
PhylomeDBiQ9D8U4.
TreeFamiTF329591.

Miscellaneous databases

NextBioi328786.
PROiQ9D8U4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D8U4.
CleanExiMM_C1QTNF2.
ExpressionAtlasiQ9D8U4. baseline and differential.
GenevisibleiQ9D8U4. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of Acrp30/adiponectin structural and functional paralogs."
    Wong G.W., Wang J., Hug C., Tsao T.S., Lodish H.F.
    Proc. Natl. Acad. Sci. U.S.A. 101:10302-10307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  5. "Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis."
    Seldin M.M., Peterson J.M., Byerly M.S., Wei Z., Wong G.W.
    J. Biol. Chem. 287:11968-11980(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FAM132B.

Entry informationi

Entry nameiC1QT2_MOUSE
AccessioniPrimary (citable) accession number: Q9D8U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: January 20, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.