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Q9D8U3

- ERP27_MOUSE

UniProt

Q9D8U3 - ERP27_MOUSE

Protein

Endoplasmic reticulum resident protein 27

Gene

Erp27

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoplasmic reticulum resident protein 27
    Short name:
    ER protein 27
    Short name:
    ERp27
    Gene namesi
    Name:Erp27
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1916437. Erp27.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 272247Endoplasmic reticulum resident protein 27PRO_0000281119Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9D8U3.
    PaxDbiQ9D8U3.
    PRIDEiQ9D8U3.

    Expressioni

    Gene expression databases

    BgeeiQ9D8U3.
    CleanExiMM_ERP27.
    GenevestigatoriQ9D8U3.

    Interactioni

    Subunit structurei

    Interacts with PDIA3.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D8U3.
    SMRiQ9D8U3. Positions 38-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 152114ThioredoxinAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni230 – 2334PDIA3-binding siteBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi269 – 2724Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 1 thioredoxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG255456.
    GeneTreeiENSGT00740000115202.
    HOGENOMiHOG000112391.
    HOVERGENiHBG081481.
    InParanoidiQ9D8U3.
    OMAiEHVQNFC.
    OrthoDBiEOG7P2XT5.
    PhylomeDBiQ9D8U3.
    TreeFamiTF106381.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR012336. Thioredoxin-like_fold.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 2 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D8U3-1 [UniParc]FASTAAdd to Basket

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    MKITRSRCLI LSFVLVCGLV PEVTADVEEA TDGLSTTQEP IWLTDVPATV    50
    ELIAAAEVAV IGFFQDLEIP IVSVFRSMAR QFQDVSFGIS NHSEVLTHYN 100
    VTSNSICLFR LVDDQQLHLN AEDIENLDAA KLSRFIHVNN LHWVTEYSPM 150
    IAAGLFNTMV QTHLLLMMKK TSPEYEESMR RYREAAKLFQ GQILFVLVDS 200
    GKRENGKVMS YFKLKESQLP ALAIYESVDD KWDTLPIAEV TVEKVRGFCE 250
    GFLKGLLQRD HEAEGDSGKE EL 272
    Length:272
    Mass (Da):30,693
    Last modified:June 1, 2001 - v1
    Checksum:iB4BC442A4C54E60C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041N → S in AAI04407. (PubMed:15489334)Curated
    Sequence conflicti104 – 1041N → S in AAI04408. (PubMed:15489334)Curated
    Sequence conflicti138 – 1381V → M in AAI04407. (PubMed:15489334)Curated
    Sequence conflicti138 – 1381V → M in AAI04408. (PubMed:15489334)Curated
    Sequence conflicti261 – 2611H → L in AAI04407. (PubMed:15489334)Curated
    Sequence conflicti261 – 2611H → L in AAI04408. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007684 mRNA. Translation: BAB25188.1.
    AK131830 mRNA. Translation: BAE20822.1.
    BC104406 mRNA. Translation: AAI04407.1.
    BC104407 mRNA. Translation: AAI04408.1.
    CCDSiCCDS20660.1.
    RefSeqiNP_081259.1. NM_026983.2.
    UniGeneiMm.33692.

    Genome annotation databases

    EnsembliENSMUST00000032343; ENSMUSP00000032343; ENSMUSG00000030219.
    GeneIDi69187.
    KEGGimmu:69187.
    UCSCiuc009emm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007684 mRNA. Translation: BAB25188.1 .
    AK131830 mRNA. Translation: BAE20822.1 .
    BC104406 mRNA. Translation: AAI04407.1 .
    BC104407 mRNA. Translation: AAI04408.1 .
    CCDSi CCDS20660.1.
    RefSeqi NP_081259.1. NM_026983.2.
    UniGenei Mm.33692.

    3D structure databases

    ProteinModelPortali Q9D8U3.
    SMRi Q9D8U3. Positions 38-255.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi Q9D8U3.
    PaxDbi Q9D8U3.
    PRIDEi Q9D8U3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032343 ; ENSMUSP00000032343 ; ENSMUSG00000030219 .
    GeneIDi 69187.
    KEGGi mmu:69187.
    UCSCi uc009emm.1. mouse.

    Organism-specific databases

    CTDi 121506.
    MGIi MGI:1916437. Erp27.

    Phylogenomic databases

    eggNOGi NOG255456.
    GeneTreei ENSGT00740000115202.
    HOGENOMi HOG000112391.
    HOVERGENi HBG081481.
    InParanoidi Q9D8U3.
    OMAi EHVQNFC.
    OrthoDBi EOG7P2XT5.
    PhylomeDBi Q9D8U3.
    TreeFami TF106381.

    Miscellaneous databases

    ChiTaRSi ERP27. mouse.
    NextBioi 328798.
    PROi Q9D8U3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D8U3.
    CleanExi MM_ERP27.
    Genevestigatori Q9D8U3.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 2 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiERP27_MOUSE
    AccessioniPrimary (citable) accession number: Q9D8U3
    Secondary accession number(s): Q3SX97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3