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Protein

SRA stem-loop-interacting RNA-binding protein, mitochondrial

Gene

Slirp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • flagellated sperm motility Source: MGI
  • mitochondrion morphogenesis Source: MGI
  • negative regulation of mitochondrial RNA catabolic process Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • single fertilization Source: MGI
  • spermatid development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SRA stem-loop-interacting RNA-binding protein, mitochondrial
Gene namesi
Name:Slirp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1916394 Slirp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000247052? – 112SRA stem-loop-interacting RNA-binding protein, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei104PhosphothreonineCombined sources1
Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D8T7
PaxDbiQ9D8T7
PeptideAtlasiQ9D8T7
PRIDEiQ9D8T7

PTM databases

iPTMnetiQ9D8T7
PhosphoSitePlusiQ9D8T7
SwissPalmiQ9D8T7

Expressioni

Gene expression databases

BgeeiENSMUSG00000021040
CleanExiMM_1810035L17RIK
ExpressionAtlasiQ9D8T7 baseline and differential
GenevisibleiQ9D8T7 MM

Interactioni

Protein-protein interaction databases

IntActiQ9D8T7, 3 interactors
MINTiQ9D8T7
STRINGi10090.ENSMUSP00000125341

Structurei

3D structure databases

ProteinModelPortaliQ9D8T7
SMRiQ9D8T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 98RRMPROSITE-ProRule annotationAdd BLAST80

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00390000008624
HOGENOMiHOG000276232
HOVERGENiHBG079935
InParanoidiQ9D8T7
OMAiWTISSKE
OrthoDBiEOG091G0VXP
PhylomeDBiQ9D8T7
TreeFamiTF319527

Family and domain databases

CDDicd12242 RRM_SLIRP, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034152 SLIRP_RRM
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D8T7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASAIKGLS ALRSSTGRPI AFVRKIPWTA AASELREHFA QFGHVRRCTV
60 70 80 90 100
PFDKETGFHR GMGWVQFSSQ EELQNALQQE HHIIDGVKIH VQAQRAKALH
110
GAQTSDEERF LR
Length:112
Mass (Da):12,605
Last modified:July 25, 2006 - v2
Checksum:i3A03B372E1DA05DB
GO
Isoform 2 (identifier: Q9D8T7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-112: IHVQAQRAKALHGAQTSDEERFLR → VSISDVCSTSL

Note: No experimental confirmation available.
Show »
Length:99
Mass (Da):10,953
Checksum:i0A520C6F6F04BA1B
GO

Sequence cautioni

The sequence CAC34586 differs from that shown. Reason: Frameshift at position 4.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51P → H in BAB25197 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01990789 – 112IHVQA…ERFLR → VSISDVCSTSL in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293625 mRNA Translation: CAC34586.1 Frameshift.
AK007699 mRNA Translation: BAB25197.1
BC100567 mRNA Translation: AAI00568.1
CCDSiCCDS36503.1 [Q9D8T7-1]
RefSeqiNP_081234.2, NM_026958.3 [Q9D8T7-1]
UniGeneiMm.355701

Genome annotation databases

EnsembliENSMUST00000160488; ENSMUSP00000124174; ENSMUSG00000021040 [Q9D8T7-2]
ENSMUST00000161023; ENSMUSP00000125341; ENSMUSG00000021040 [Q9D8T7-1]
GeneIDi380773
KEGGimmu:380773
UCSCiuc007ojd.2 mouse [Q9D8T7-1]
uc007oje.2 mouse [Q9D8T7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSLIRP_MOUSE
AccessioniPrimary (citable) accession number: Q9D8T7
Secondary accession number(s): Q497G4, Q99JH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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