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Protein

GTPase RhebL1

Gene

Rhebl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38MagnesiumBy similarity1
Binding sitei63GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 21GTPBy similarity6
Nucleotide bindingi32 – 38GTPBy similarity7
Nucleotide bindingi119 – 122GTPBy similarity4
Nucleotide bindingi149 – 150GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase RhebL1
Alternative name(s):
Ras homolog enriched in brain-like protein 1
Short name:
Rheb-like protein 1
Gene namesi
Name:Rhebl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1916409. Rhebl1.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003242941 – 181GTPase RhebL1Add BLAST181
PropeptideiPRO_0000324295182 – 184Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei181Cysteine methyl esterBy similarity1
Lipidationi181S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9D8T3.
PaxDbiQ9D8T3.
PRIDEiQ9D8T3.

PTM databases

iPTMnetiQ9D8T3.
PhosphoSitePlusiQ9D8T3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023755.
CleanExiMM_RHEBL1.
GenevisibleiQ9D8T3. MM.

Interactioni

Subunit structurei

Interacts with MTOR.By similarity

Protein-protein interaction databases

BioGridi213261. 5 interactors.
IntActiQ9D8T3. 6 interactors.
MINTiMINT-1340904.
STRINGi10090.ENSMUSP00000024518.

Structurei

3D structure databases

ProteinModelPortaliQ9D8T3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133696.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9D8T3.
KOiK07849.
OMAiGKTRMPV.
OrthoDBiEOG091G0ONO.
PhylomeDBiQ9D8T3.
TreeFamiTF314986.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51421. RAS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVRYRKVA ILGYRSVGKT SLAHQFVEGE FLEGYDPTVE NTYSKTVTLG
60 70 80 90 100
KDEFHLHLVD TAGQDEYSIL PYSLIIGVHG YVLVYSVNSL RSFQIVKNLY
110 120 130 140 150
QKLHEGHGKT RLSVLLVGNK ADLSPEREVQ AVEGKKLAES WGAMFMESSA
160 170 180
RDNQLTQDVF IKVIQEIARV ENSYGRQDRR CYLM
Length:184
Mass (Da):20,934
Last modified:June 1, 2001 - v1
Checksum:i8F6A6849A533A0DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327413 mRNA. Translation: AAP92805.1.
AK007708 mRNA. Translation: BAB25203.1.
AK135858 mRNA. Translation: BAE22699.1.
BC016521 mRNA. Translation: AAH16521.1.
CCDSiCCDS27809.1.
RefSeqiNP_081243.1. NM_026967.4.
UniGeneiMm.259708.

Genome annotation databases

EnsembliENSMUST00000024518; ENSMUSP00000024518; ENSMUSG00000023755.
GeneIDi69159.
KEGGimmu:69159.
UCSCiuc011zzb.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiREBL1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families