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Protein

GTPase RhebL1

Gene

Rhebl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381MagnesiumBy similarity
Binding sitei63 – 631GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 216GTPBy similarity
Nucleotide bindingi32 – 387GTPBy similarity
Nucleotide bindingi119 – 1224GTPBy similarity
Nucleotide bindingi149 – 1502GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase RhebL1
Alternative name(s):
Ras homolog enriched in brain-like protein 1
Short name:
Rheb-like protein 1
Gene namesi
Name:Rhebl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1916409. Rhebl1.

Subcellular locationi

  • Endomembrane system By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181GTPase RhebL1PRO_0000324294Add
BLAST
Propeptidei182 – 1843Removed in mature formBy similarityPRO_0000324295

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei181 – 1811Cysteine methyl esterBy similarity
Lipidationi181 – 1811S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9D8T3.
PaxDbiQ9D8T3.
PRIDEiQ9D8T3.

PTM databases

iPTMnetiQ9D8T3.
PhosphoSiteiQ9D8T3.

Expressioni

Gene expression databases

BgeeiQ9D8T3.
CleanExiMM_RHEBL1.
GenevisibleiQ9D8T3. MM.

Interactioni

Subunit structurei

Interacts with MTOR.By similarity

Protein-protein interaction databases

BioGridi213261. 5 interactions.
MINTiMINT-1340904.
STRINGi10090.ENSMUSP00000024518.

Structurei

3D structure databases

ProteinModelPortaliQ9D8T3.
SMRiQ9D8T3. Positions 5-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9D8T3.
KOiK07849.
OMAiRYRKVAI.
OrthoDBiEOG7Q2N6K.
PhylomeDBiQ9D8T3.
TreeFamiTF314986.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVRYRKVA ILGYRSVGKT SLAHQFVEGE FLEGYDPTVE NTYSKTVTLG
60 70 80 90 100
KDEFHLHLVD TAGQDEYSIL PYSLIIGVHG YVLVYSVNSL RSFQIVKNLY
110 120 130 140 150
QKLHEGHGKT RLSVLLVGNK ADLSPEREVQ AVEGKKLAES WGAMFMESSA
160 170 180
RDNQLTQDVF IKVIQEIARV ENSYGRQDRR CYLM
Length:184
Mass (Da):20,934
Last modified:June 1, 2001 - v1
Checksum:i8F6A6849A533A0DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327413 mRNA. Translation: AAP92805.1.
AK007708 mRNA. Translation: BAB25203.1.
AK135858 mRNA. Translation: BAE22699.1.
BC016521 mRNA. Translation: AAH16521.1.
CCDSiCCDS27809.1.
RefSeqiNP_081243.1. NM_026967.4.
UniGeneiMm.259708.

Genome annotation databases

EnsembliENSMUST00000024518; ENSMUSP00000024518; ENSMUSG00000023755.
GeneIDi69159.
KEGGimmu:69159.
UCSCiuc011zzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327413 mRNA. Translation: AAP92805.1.
AK007708 mRNA. Translation: BAB25203.1.
AK135858 mRNA. Translation: BAE22699.1.
BC016521 mRNA. Translation: AAH16521.1.
CCDSiCCDS27809.1.
RefSeqiNP_081243.1. NM_026967.4.
UniGeneiMm.259708.

3D structure databases

ProteinModelPortaliQ9D8T3.
SMRiQ9D8T3. Positions 5-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213261. 5 interactions.
MINTiMINT-1340904.
STRINGi10090.ENSMUSP00000024518.

PTM databases

iPTMnetiQ9D8T3.
PhosphoSiteiQ9D8T3.

Proteomic databases

MaxQBiQ9D8T3.
PaxDbiQ9D8T3.
PRIDEiQ9D8T3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024518; ENSMUSP00000024518; ENSMUSG00000023755.
GeneIDi69159.
KEGGimmu:69159.
UCSCiuc011zzb.1. mouse.

Organism-specific databases

CTDi121268.
MGIiMGI:1916409. Rhebl1.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9D8T3.
KOiK07849.
OMAiRYRKVAI.
OrthoDBiEOG7Q2N6K.
PhylomeDBiQ9D8T3.
TreeFamiTF314986.

Miscellaneous databases

PROiQ9D8T3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D8T3.
CleanExiMM_RHEBL1.
GenevisibleiQ9D8T3. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B."
    Yuan J., Shan Y., Chen X., Tang W., Luo K., Ni J., Wan B., Yu L.
    Mol. Biol. Rep. 32:205-214(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiREBL1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.