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Protein

ADP-ribosylation factor GTPase-activating protein 3

Gene

Arfgap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).By similarity

Enzyme regulationi

GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor GTPase-activating protein 3
Short name:
ARF GAP 3
Gene namesi
Name:Arfgap3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913501. Arfgap3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000741941 – 523ADP-ribosylation factor GTPase-activating protein 3Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineBy similarity1
Modified residuei241PhosphoserineCombined sources1
Modified residuei270PhosphoserineBy similarity1
Modified residuei274PhosphoserineBy similarity1
Modified residuei331PhosphoserineCombined sources1
Modified residuei377PhosphoserineBy similarity1
Modified residuei435PhosphoserineBy similarity1
Modified residuei458PhosphoserineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Modified residuei464PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D8S3.
MaxQBiQ9D8S3.
PaxDbiQ9D8S3.
PeptideAtlasiQ9D8S3.
PRIDEiQ9D8S3.

PTM databases

iPTMnetiQ9D8S3.
PhosphoSitePlusiQ9D8S3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064893.

Structurei

3D structure databases

ProteinModelPortaliQ9D8S3.
SMRiQ9D8S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 126Arf-GAPPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi348 – 408Ser-richAdd BLAST61

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0706. Eukaryota.
COG5347. LUCA.
HOGENOMiHOG000162970.
HOVERGENiHBG050563.
InParanoidiQ9D8S3.
KOiK12493.
PhylomeDBiQ9D8S3.
TreeFamiTF313985.

Family and domain databases

InterProiView protein in InterPro
IPR001164. ArfGAP.
PfamiView protein in Pfam
PF01412. ArfGap. 1 hit.
PRINTSiPR00405. REVINTRACTNG.
SMARTiView protein in SMART
SM00105. ArfGap. 1 hit.
PROSITEiView protein in PROSITE
PS50115. ARFGAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D8S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDPSKQDIL AIFKRLRSVP TNKVCFDCGA KNPSWASISY GVFLCIDCSG
60 70 80 90 100
SHRSLGVHLS FIRSTELDSN WSWFQLRCMQ VGGNSNASSF FHQHGCATKD
110 120 130 140 150
TNAKYNSRAA QLYREKIKTL ATQATRRHGT DLWLDSCAAP PVSPPPKEED
160 170 180 190 200
FFASHASLEV SGAMQASAQP ESASSTPWGL ETTPEKHEGG PGQGPSVEGL
210 220 230 240 250
NTPGKAAPEV SSIIKKKPNQ AKKGLGAKKG SLGAQKLTNT SFTEIEKQAQ
260 270 280 290 300
AVDKRKEQED LARGAPKEES IVSSLRLAYK DLEISRKKDE RLNLSGQKKV
310 320 330 340 350
EAERLGMGFG SCRSGISHSV TSDMQTIEQE SPTLAKPRRK YQEDPEDSYF
360 370 380 390 400
SSSSKWSEQS SRYFDDPMEL RSSSFSSWDD GADSYWKKDS SRDPEPAMRS
410 420 430 440 450
TGSSDRPSAR RKPEYEPIGS TDEAQKKFGN VKAISSDMYF GIQAQTDFET
460 470 480 490 500
RARLERLSTS SSISSADLFD EQRKQTAGNY NLSNVLPNAP DMAQFKQGVR
510 520
SVAGKLSVFA NGVMTSIQDR YGS
Length:523
Mass (Da):57,456
Last modified:January 15, 2008 - v2
Checksum:iFC093B11DB765BC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208P → PA in BAB25220 (PubMed:16141072).Curated1
Sequence conflicti361S → SS in BAB25220 (PubMed:16141072).Curated1
Sequence conflicti361S → SS in BAC26229 (PubMed:16141072).Curated1
Sequence conflicti361S → SS in AAH04081 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007732 mRNA. Translation: BAB25220.1.
AK028990 mRNA. Translation: BAC26229.1.
AK075788 mRNA. Translation: BAC35959.1.
AK169107 mRNA. Translation: BAE40889.1.
BC004081 mRNA. Translation: AAH04081.1.
BC060369 mRNA. Translation: AAH60369.1.
RefSeqiNP_079721.2. NM_025445.4.
XP_006521316.2. XM_006521253.3.
XP_006521318.2. XM_006521255.3.
UniGeneiMm.258910.

Genome annotation databases

GeneIDi66251.
KEGGimmu:66251.
UCSCiuc007xag.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiARFG3_MOUSE
AccessioniPrimary (citable) accession number: Q9D8S3
Secondary accession number(s): Q544V6, Q8BW06, Q99KN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 15, 2008
Last modified: August 30, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot