ID   RM17_MOUSE              Reviewed;         176 AA.
AC   Q9D8P4; Q91VR0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 143.
DE   RecName: Full=Large ribosomal subunit protein bL17m {ECO:0000305};
DE   AltName: Full=39S ribosomal protein L17, mitochondrial;
DE            Short=L17mt;
DE            Short=MRP-L17;
DE   Flags: Precursor;
GN   Name=Mrpl17;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Pancreas;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-13, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=OF1; TISSUE=Hippocampus;
RA   Lubec G., Sunyer B., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC       which comprises a 16S rRNA and about 50 distinct proteins.
CC       {ECO:0000250|UniProtKB:Q9NRX2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NRX2}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9D8P4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9D8P4-2; Sequence=VSP_018590, VSP_018591;
CC   -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL17 family.
CC       {ECO:0000305}.
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DR   EMBL; AK007828; BAB25288.1; -; mRNA.
DR   EMBL; AK144092; BAE25695.1; -; mRNA.
DR   EMBL; AK147957; BAE28251.1; -; mRNA.
DR   EMBL; BC010718; AAH10718.1; -; mRNA.
DR   CCDS; CCDS21662.1; -. [Q9D8P4-1]
DR   RefSeq; NP_079577.1; NM_025301.2. [Q9D8P4-1]
DR   AlphaFoldDB; Q9D8P4; -.
DR   SMR; Q9D8P4; -.
DR   BioGRID; 205204; 3.
DR   ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR   STRING; 10090.ENSMUSP00000117971; -.
DR   GlyGen; Q9D8P4; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9D8P4; -.
DR   PhosphoSitePlus; Q9D8P4; -.
DR   EPD; Q9D8P4; -.
DR   MaxQB; Q9D8P4; -.
DR   PaxDb; 10090-ENSMUSP00000117971; -.
DR   PeptideAtlas; Q9D8P4; -.
DR   ProteomicsDB; 299906; -. [Q9D8P4-1]
DR   ProteomicsDB; 299907; -. [Q9D8P4-2]
DR   Pumba; Q9D8P4; -.
DR   Antibodypedia; 64019; 71 antibodies from 19 providers.
DR   DNASU; 27397; -.
DR   Ensembl; ENSMUST00000033170.7; ENSMUSP00000147523.2; ENSMUSG00000030879.11. [Q9D8P4-2]
DR   Ensembl; ENSMUST00000124482.3; ENSMUSP00000117971.2; ENSMUSG00000030879.11. [Q9D8P4-1]
DR   GeneID; 27397; -.
DR   KEGG; mmu:27397; -.
DR   UCSC; uc009izl.1; mouse. [Q9D8P4-1]
DR   UCSC; uc009izm.1; mouse. [Q9D8P4-2]
DR   AGR; MGI:1351608; -.
DR   CTD; 63875; -.
DR   MGI; MGI:1351608; Mrpl17.
DR   VEuPathDB; HostDB:ENSMUSG00000030879; -.
DR   eggNOG; KOG3280; Eukaryota.
DR   GeneTree; ENSGT00390000010698; -.
DR   HOGENOM; CLU_074407_3_2_1; -.
DR   InParanoid; Q9D8P4; -.
DR   OMA; YKGNPYP; -.
DR   OrthoDB; 2907681at2759; -.
DR   PhylomeDB; Q9D8P4; -.
DR   TreeFam; TF105844; -.
DR   Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR   Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR   BioGRID-ORCS; 27397; 28 hits in 83 CRISPR screens.
DR   ChiTaRS; Mrpl17; mouse.
DR   PRO; PR:Q9D8P4; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q9D8P4; Protein.
DR   Bgee; ENSMUSG00000030879; Expressed in embryonic cell in blastocyst and 269 other cell types or tissues.
DR   ExpressionAtlas; Q9D8P4; baseline and differential.
DR   GO; GO:0005743; C:mitochondrial inner membrane; HDA:MGI.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISA:MGI.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; TAS:MGI.
DR   GO; GO:0032543; P:mitochondrial translation; NAS:ComplexPortal.
DR   GO; GO:0006412; P:translation; ISA:MGI.
DR   Gene3D; 3.90.1030.10; Ribosomal protein L17; 1.
DR   InterPro; IPR000456; Ribosomal_bL17.
DR   InterPro; IPR036373; Ribosomal_bL17_sf.
DR   NCBIfam; TIGR00059; L17; 1.
DR   PANTHER; PTHR14413:SF16; 39S RIBOSOMAL PROTEIN L17, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR14413; RIBOSOMAL PROTEIN L17; 1.
DR   Pfam; PF01196; Ribosomal_L17; 1.
DR   SUPFAM; SSF64263; Prokaryotic ribosomal protein L17; 1.
DR   Genevisible; Q9D8P4; MM.
PE   1: Evidence at protein level;
KW   Alternative splicing; Direct protein sequencing; Mitochondrion;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT   TRANSIT         1..8
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250|UniProtKB:Q3T0L3"
FT   CHAIN           9..176
FT                   /note="Large ribosomal subunit protein bL17m"
FT                   /id="PRO_0000237332"
FT   VAR_SEQ         82..116
FT                   /note="EKDLIPKLFKVLAPRFQGQNGNYTRMLQIPNRKEQ -> VSAPYLLVRKESL
FT                   ENRVPGRLKAGHSFMYQTCELP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_018590"
FT   VAR_SEQ         117..176
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_018591"
SQ   SEQUENCE   176 AA;  20249 MW;  3A0CBC71740A4E42 CRC64;
     MRLSLAAAIS HGRVYRRLGL GPESRIHLLR NLLTGLVRHE RIEATWARAD EMRGYAEKLI
     DYGKLGDTNE RAMRMADFWL TEKDLIPKLF KVLAPRFQGQ NGNYTRMLQI PNRKEQDRAK
     MAVIEYKGNY LPPLPLPHRD SNLTLLNQLL LGLQQDLHHN QDASLHSSCT VQTPKT
//