Q9D8P4 (RM17_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L17, mitochondrial
Short name=L17mt
Short name=MRP-L17

Gene names

Name:

Mrpl17

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion Potential.
Sequence similarities	Belongs to the ribosomal protein L17P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial genome maintenance Traceable author statement PubMed 10593885. Source: MGI translation Inferred from sequence alignment PubMed 10593885. Source: MGI
Cellular_component	mitochondrial inner membrane Inferred from direct assay PubMed 12865426. Source: MGI mitochondrial large ribosomal subunit Inferred from sequence alignment PubMed 10593885. Source: MGI
Molecular_function	structural constituent of ribosome Inferred from sequence alignment PubMed 10593885. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9D8P4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9D8P4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     82-116: EKDLIPKLFKVLAPRFQGQNGNYTRMLQIPNRKEQ → VSAPYLLVRKESLENRVPGRLKAGHSFMYQTCELP
     117-176: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 8	8	Mitochondrion By similarity
	Chain	9 – 176	168	39S ribosomal protein L17, mitochondrial		PRO_0000237332
Natural variations
	Alternative sequence	82 – 116	35	EKDLI…NRKEQ → VSAPYLLVRKESLENRVPGR LKAGHSFMYQTCELP in isoform 2.		VSP_018590
	Alternative sequence	117 – 176	60	Missing in isoform 2.		VSP_018591

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 3A0CBC71740A4E42	FASTA	176	20,249
	10 20 30 40 50 60 MRLSLAAAIS HGRVYRRLGL GPESRIHLLR NLLTGLVRHE RIEATWARAD EMRGYAEKLI 70 80 90 100 110 120 DYGKLGDTNE RAMRMADFWL TEKDLIPKLF KVLAPRFQGQ NGNYTRMLQI PNRKEQDRAK 130 140 150 160 170 MAVIEYKGNY LPPLPLPHRD SNLTLLNQLL LGLQQDLHHN QDASLHSSCT VQTPKT
	Isoform 2 [UniParc]. Checksum: 9627DA824FA17466	FASTA	116	13,340
	10 20 30 40 50 60 MRLSLAAAIS HGRVYRRLGL GPESRIHLLR NLLTGLVRHE RIEATWARAD EMRGYAEKLI 70 80 90 100 110 DYGKLGDTNE RAMRMADFWL TVSAPYLLVR KESLENRVPG RLKAGHSFMY QTCELP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Pancreas.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: FVB/N. Tissue: Mammary gland.
[3]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-13, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK007828 mRNA. Translation: BAB25288.1. AK144092 mRNA. Translation: BAE25695.1. AK147957 mRNA. Translation: BAE28251.1. BC010718 mRNA. Translation: AAH10718.1.
IPI	IPI00111784. IPI00473469.
RefSeq	NP_079577.1. NM_025301.2.
UniGene	Mm.44225.
3D structure databases
ProteinModelPortal	Q9D8P4.
SMR	Q9D8P4. Positions 28-129.
ModBase	Search...
PTM databases
PhosphoSite	Q9D8P4.
Proteomic databases
PaxDb	Q9D8P4.
PRIDE	Q9D8P4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000124482; ENSMUSP00000117971; ENSMUSG00000030879.
GeneID	27397.
KEGG	mmu:27397.
UCSC	uc009izl.1. mouse. uc009izm.1. mouse.
Organism-specific databases
CTD	63875.
MGI	MGI:1351608. Mrpl17.
Phylogenomic databases
eggNOG	COG0203.
GeneTree	ENSGT00390000010698.
HOGENOM	HOG000019780.
HOVERGEN	HBG056029.
InParanoid	Q9D8P4.
KO	K02879.
OMA	DEVRFYA.
OrthoDB	EOG41C6XH.
Gene expression databases
ArrayExpress	Q9D8P4.
Bgee	Q9D8P4.
CleanEx	MM_MRPL17.
Genevestigator	Q9D8P4.
GermOnline	ENSMUSG00000030879. Mus musculus.
Family and domain databases
Gene3D	3.90.1030.10. 1 hit.
InterPro	IPR000456. Ribosomal_L17. [Graphical view]
PANTHER	PTHR14413. PTHR14413. 1 hit.
Pfam	PF01196. Ribosomal_L17. 1 hit. [Graphical view]
SUPFAM	SSF64263. Ribosomal_L17. 1 hit.
TIGRFAMs	TIGR00059. L17. 1 hit.
PROSITE	PS01167. RIBOSOMAL_L17. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	305376.
SOURCE	Search...

Entry information

Entry name

RM17_MOUSE

Accession

Primary (citable) accession number: Q9D8P4
Secondary accession number(s): Q91VR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program