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Protein

Protein lin-37 homolog

Gene

Lin37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1538133. G0 and Early G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-37 homolog
Alternative name(s):
Antolefinin
Antolefinine
Gene namesi
Name:Lin37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1922910. Lin37.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384801 – 246Protein lin-37 homologAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei135PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei167PhosphothreonineBy similarity1
Modified residuei182PhosphoserineBy similarity1
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D8N6.
PaxDbiQ9D8N6.
PRIDEiQ9D8N6.

PTM databases

iPTMnetiQ9D8N6.
PhosphoSitePlusiQ9D8N6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036845.
CleanExiMM_LIN37.
ExpressionAtlasiQ9D8N6. baseline and differential.
GenevisibleiQ9D8N6. MM.

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048557.

Structurei

3D structure databases

ProteinModelPortaliQ9D8N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 203Pro-richAdd BLAST68

Phylogenomic databases

eggNOGiENOG410II8K. Eukaryota.
ENOG4111QJM. LUCA.
GeneTreeiENSGT00390000002748.
HOGENOMiHOG000006536.
HOVERGENiHBG054424.
InParanoidiQ9D8N6.
OMAiKKIRQKW.
OrthoDBiEOG091G0HEY.
PhylomeDBiQ9D8N6.
TreeFamiTF329230.

Family and domain databases

InterProiIPR028226. LIN37.
[Graphical view]
PfamiPF15306. LIN37. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D8N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPVKVKVEK SEMEMAKARN QLDAVLQCLL EKSHMDRERL DEEAGKTPLD
60 70 80 90 100
THNKDCSIAA TGKRPSARFP HQRRKKRREM DDGLAEGGPQ RSNTYVIKLF
110 120 130 140 150
DRSVDLAQFS ENTPLYPICR AWMRNSPTVR ERERSPGSPL PPLPEDGEGS
160 170 180 190 200
EVINSKNRDV YKLPPPTAPG PLGDACRSRI PSPLQPETEG TPDDEPSEPE
210 220 230 240
PSPSTLIYRN MQRWKRIRQR WKEASHRNQL RYSESMKILR EMYDRQ
Length:246
Mass (Da):28,378
Last modified:June 1, 2001 - v1
Checksum:i6FD6104D9945A81D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY428767 mRNA. Translation: AAR06606.1.
AK007858 mRNA. Translation: BAB25310.1.
CCDSiCCDS21098.1.
RefSeqiNP_001277498.1. NM_001290569.1.
NP_083653.1. NM_029377.2.
UniGeneiMm.379242.

Genome annotation databases

EnsembliENSMUST00000043975; ENSMUSP00000048557; ENSMUSG00000036845.
GeneIDi75660.
KEGGimmu:75660.
UCSCiuc009gex.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY428767 mRNA. Translation: AAR06606.1.
AK007858 mRNA. Translation: BAB25310.1.
CCDSiCCDS21098.1.
RefSeqiNP_001277498.1. NM_001290569.1.
NP_083653.1. NM_029377.2.
UniGeneiMm.379242.

3D structure databases

ProteinModelPortaliQ9D8N6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048557.

PTM databases

iPTMnetiQ9D8N6.
PhosphoSitePlusiQ9D8N6.

Proteomic databases

EPDiQ9D8N6.
PaxDbiQ9D8N6.
PRIDEiQ9D8N6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043975; ENSMUSP00000048557; ENSMUSG00000036845.
GeneIDi75660.
KEGGimmu:75660.
UCSCiuc009gex.1. mouse.

Organism-specific databases

CTDi55957.
MGIiMGI:1922910. Lin37.

Phylogenomic databases

eggNOGiENOG410II8K. Eukaryota.
ENOG4111QJM. LUCA.
GeneTreeiENSGT00390000002748.
HOGENOMiHOG000006536.
HOVERGENiHBG054424.
InParanoidiQ9D8N6.
OMAiKKIRQKW.
OrthoDBiEOG091G0HEY.
PhylomeDBiQ9D8N6.
TreeFamiTF329230.

Enzyme and pathway databases

ReactomeiR-MMU-1538133. G0 and Early G1.

Miscellaneous databases

PROiQ9D8N6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036845.
CleanExiMM_LIN37.
ExpressionAtlasiQ9D8N6. baseline and differential.
GenevisibleiQ9D8N6. MM.

Family and domain databases

InterProiIPR028226. LIN37.
[Graphical view]
PfamiPF15306. LIN37. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIN37_MOUSE
AccessioniPrimary (citable) accession number: Q9D8N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.