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Protein

Elongation factor 1-gamma

Gene

Eef1g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably plays a role in anchoring the complex to other cellular components.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-gamma
Short name:
EF-1-gamma
Alternative name(s):
eEF-1B gamma
Gene namesi
Name:Eef1g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914410 Eef1g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002088142 – 437Elongation factor 1-gammaAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei147N6-acetyllysineCombined sources1
Modified residuei212N6-acetyllysineCombined sources1
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei401N6-acetyllysineCombined sources1
Modified residuei434N6-acetyllysine; alternateCombined sources1
Modified residuei434N6-malonyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9D8N0
MaxQBiQ9D8N0
PaxDbiQ9D8N0
PRIDEiQ9D8N0

2D gel databases

REPRODUCTION-2DPAGEQ9D8N0

PTM databases

iPTMnetiQ9D8N0
PhosphoSitePlusiQ9D8N0
SwissPalmiQ9D8N0

Expressioni

Gene expression databases

BgeeiENSMUSG00000071644
CleanExiMM_EEF1G
ExpressionAtlasiQ9D8N0 baseline and differential
GenevisibleiQ9D8N0 MM

Interactioni

Subunit structurei

EF-1 is composed of four subunits: alpha, beta, delta, and gamma.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211986, 6 interactors
CORUMiQ9D8N0
DIPiDIP-32124N
IntActiQ9D8N0, 12 interactors
MINTiQ9D8N0
STRINGi10090.ENSMUSP00000093955

Structurei

3D structure databases

ProteinModelPortaliQ9D8N0
SMRiQ9D8N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 87GST N-terminalAdd BLAST86
Domaini88 – 216GST C-terminalAdd BLAST129
Domaini276 – 437EF-1-gamma C-terminalPROSITE-ProRule annotationAdd BLAST162

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
KOG1627 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00390000007552
HOGENOMiHOG000201196
HOVERGENiHBG051444
InParanoidiQ9D8N0
KOiK03233
OMAiDYEVYDW
OrthoDBiEOG091G06QR
PhylomeDBiQ9D8N0
TreeFamiTF314343

Family and domain databases

Gene3Di3.30.70.1010, 1 hit
InterProiView protein in InterPro
IPR001662 EF1B_G_C
IPR036433 EF1B_G_C_sf
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00647 EF1G, 1 hit
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SMARTiView protein in SMART
SM01183 EF1G, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
SSF89942 SSF89942, 1 hit
PROSITEiView protein in PROSITE
PS50040 EF1G_C, 1 hit
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGTLYTYP ENWRAFKALI AAQYSGAQVR VLSAPPHFHF GQTNRTPEFL
60 70 80 90 100
RKFPAGKVPA FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS
110 120 130 140 150
FADSDIVPPA STWVFPTLGI MHHNKQATEN AKEEVKRILG LLDTHLKTRT
160 170 180 190 200
FLVGERVTLA DITVVCTLLW LYKQVLEPSF RQAFPNTNRW FLTCINQPQF
210 220 230 240 250
RAILGEVKLC EKMAQFDAKK FAESQPKKDT PRKEKGSREE KQKPQAERKE
260 270 280 290 300
EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE
310 320 330 340 350
DTLSVALPYF WEHFDKDGWS LWYAEYRFPE ELTQTFMSCN LITGMFQRLD
360 370 380 390 400
KLRKNAFASV ILFGTNNSSS ISGVWVFRGQ ELAFPLSPDW QVDYESYTWR
410 420 430
KLDPGSEETQ TLVREYFSWE GTFQHVGKAV NQGKIFK
Length:437
Mass (Da):50,061
Last modified:January 23, 2007 - v3
Checksum:i403A9C0E95E27454
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4G → E in BAB29238 (PubMed:16141072).Curated1
Sequence conflicti173K → R in AAL23895 (Ref. 1) Curated1
Sequence conflicti227K → N in BAB27948 (PubMed:16141072).Curated1
Sequence conflicti340N → T in AAL23895 (Ref. 1) Curated1
Sequence conflicti413V → G in AAL23895 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321126 mRNA Translation: AAL23895.1
AK007869 mRNA Translation: BAB25320.1
AK011951 mRNA No translation available.
AK011973 mRNA Translation: BAB27948.1
AK014277 mRNA Translation: BAB29238.3
AK050636 mRNA Translation: BAC34356.1
AK081859 mRNA Translation: BAC38351.1
BC083071 mRNA Translation: AAH83071.1
CCDSiCCDS29563.1
RefSeqiNP_080283.3, NM_026007.4
UniGeneiMm.247762
Mm.379129

Genome annotation databases

EnsembliENSMUST00000052248; ENSMUSP00000093955; ENSMUSG00000071644
GeneIDi67160
KEGGimmu:67160
UCSCiuc008goi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiEF1G_MOUSE
AccessioniPrimary (citable) accession number: Q9D8N0
Secondary accession number(s): Q920C5
, Q9CRT5, Q9CSU3, Q9D004
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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