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Q9D8M7

- PHF10_MOUSE

UniProt

Q9D8M7 - PHF10_MOUSE

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Protein
PHD finger protein 10
Gene
Phf10, Baf45a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri378 – 43558PHD-type 1; degenerate
Add
BLAST
Zinc fingeri437 – 48044PHD-type 2; degenerate
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. nervous system development Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 10
Alternative name(s):
BRG1-associated factor 45a
Short name:
BAF45a
Gene namesi
Name:Phf10
Synonyms:Baf45a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1919307. Phf10.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. npBAF complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497PHD finger protein 10
PRO_0000059298Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111Phosphoserine By similarity
Modified residuei35 – 351Phosphoserine By similarity
Modified residuei49 – 491Phosphoserine By similarity
Modified residuei269 – 2691Phosphoserine By similarity
Modified residuei296 – 2961Phosphoserine By similarity
Modified residuei300 – 3001Phosphoserine By similarity
Modified residuei326 – 3261Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D8M7.
PRIDEiQ9D8M7.

PTM databases

PhosphoSiteiQ9D8M7.

Expressioni

Tissue specificityi

Widely expressed. Expressed selectively in neural stem and progenitor cells (at protein level).1 Publication

Developmental stagei

Expressed in neural cells at 10.5-11.5 dpc. At 10.5 to 16.5 dpc, in the developing spinal cord, specifically expressed in proliferating neural progenitors of the ventricular zone. In the developing forebrain and cerebellar primordium, expression is restricted to proliferating neuroepithelial progenitors and cerebellar granule precursors.1 Publication

Gene expression databases

BgeeiQ9D8M7.
CleanExiMM_PHF10.
GenevestigatoriQ9D8M7.

Interactioni

Subunit structurei

Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Interacts with ACTL6A/BAF53A, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A and PBRM1/BAF180.1 Publication

Protein-protein interaction databases

BioGridi215123. 2 interactions.
IntActiQ9D8M7. 1 interaction.
MINTiMINT-4127642.

Structurei

3D structure databases

ProteinModelPortaliQ9D8M7.
SMRiQ9D8M7. Positions 375-478.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 294207SAY
Add
BLAST
Regioni88 – 18497Essential to induce neural progenitor proliferation
Add
BLAST
Regioni291 – 33343Essential to induce neural progenitor proliferation
Add
BLAST

Sequence similaritiesi

Belongs to the SAYP family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG279558.
HOGENOMiHOG000286026.
HOVERGENiHBG053581.
InParanoidiQ9D8M7.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9D8M7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTAAGPGAAP SPGRCDSDPA SPGAQSPKDD NEDNSNDGTH PCKRRRMGSG    50
DSSRSCETSS QDLSFSYYPA ENLIEYKWPP DETGEYYMLQ EQVSEYLGVT 100
SFKRKYPDLE RRDLSHKEKL YLRELNVITE TQCTLGLTAL RSDEVIDLMI 150
KEYPAKHAEY SVILQEKERQ RITDHYKEYS QMQQQSTQKV EASKVPEYIK 200
KAAKKAAEFN SNLNRERMEE RRAYFDLQTH VIQVPQGKYK VLPTDRTKVS 250
SYPVALIPGQ FQEYYKRYSP DELRYLPLNT ALYEPPLDPE LPALDSDGDS 300
DDGEDGGGDE KRKNKGTSDS SSGNVSEGDS PPDSQEDTFH GRQKSKDKMA 350
TPRKDGSKRS VLSKSAPGYK PKVIPNALCG ICLKGKESNK KGKAESLIHC 400
SQCDNSGHPS CLDMTMELVS MIKTYPWQCM ECKTCIICGQ PHHEEEMMFC 450
DVCDRGYHTF CVGLGAIPSG RWICDCCQRA PPTPRKVGRR GKNSKEG 497
Length:497
Mass (Da):55,840
Last modified:July 27, 2011 - v4
Checksum:iA1F27CB9F616A271
GO
Isoform 2 (identifier: Q9D8M7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-109: Missing.

Show »
Length:495
Mass (Da):55,611
Checksum:iC4D10352EBBE5FD6
GO

Sequence cautioni

The sequence AAH02206.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB25323.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei108 – 1092Missing in isoform 2.
VSP_013441

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21T → A in BAB25323. 1 Publication
Sequence conflicti10 – 101P → L in BAB25323. 1 Publication
Sequence conflicti115 – 1151S → Y in BAB25323. 1 Publication
Sequence conflicti349 – 3491M → V in BAB25323. 1 Publication
Sequence conflicti416 – 4161M → V in BAB25323. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007873 mRNA. Translation: BAB25323.1. Different initiation.
AC154411 Genomic DNA. No translation available.
AC182749 Genomic DNA. No translation available.
BC002206 mRNA. Translation: AAH02206.1. Different initiation.
CCDSiCCDS28407.2. [Q9D8M7-1]
RefSeqiNP_077212.3. NM_024250.4.
UniGeneiMm.440085.

Genome annotation databases

GeneIDi72057.
KEGGimmu:72057.
UCSCiuc008anj.2. mouse. [Q9D8M7-2]
uc029tag.1. mouse. [Q9D8M7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007873 mRNA. Translation: BAB25323.1 . Different initiation.
AC154411 Genomic DNA. No translation available.
AC182749 Genomic DNA. No translation available.
BC002206 mRNA. Translation: AAH02206.1 . Different initiation.
CCDSi CCDS28407.2. [Q9D8M7-1 ]
RefSeqi NP_077212.3. NM_024250.4.
UniGenei Mm.440085.

3D structure databases

ProteinModelPortali Q9D8M7.
SMRi Q9D8M7. Positions 375-478.
ModBasei Search...

Protein-protein interaction databases

BioGridi 215123. 2 interactions.
IntActi Q9D8M7. 1 interaction.
MINTi MINT-4127642.

PTM databases

PhosphoSitei Q9D8M7.

Proteomic databases

MaxQBi Q9D8M7.
PRIDEi Q9D8M7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 72057.
KEGGi mmu:72057.
UCSCi uc008anj.2. mouse. [Q9D8M7-2 ]
uc029tag.1. mouse. [Q9D8M7-1 ]

Organism-specific databases

CTDi 55274.
MGIi MGI:1919307. Phf10.

Phylogenomic databases

eggNOGi NOG279558.
HOGENOMi HOG000286026.
HOVERGENi HBG053581.
InParanoidi Q9D8M7.

Miscellaneous databases

NextBioi 335336.
PROi Q9D8M7.
SOURCEi Search...

Gene expression databases

Bgeei Q9D8M7.
CleanExi MM_PHF10.
Genevestigatori Q9D8M7.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
InterProi IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 2 hits.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-497 (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "An essential switch in subunit composition of a chromatin remodeling complex during neural development."
    Lessard J., Wu J.I., Ranish J.A., Wan M., Winslow M.M., Staahl B.T., Wu H., Aebersold R., Graef I.A., Crabtree G.R.
    Neuron 55:201-215(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, FUNCTION OF THE NBAF AND NPBAF COMPLEXES, IDENTIFICATION IN THE NPBAF COMPLEX, INTERACTION WITH ACTL6A; SMARCA2; SMARCA4 AND PBRM1, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPHF10_MOUSE
AccessioniPrimary (citable) accession number: Q9D8M7
Secondary accession number(s): E9QLI2, Q99LV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-88 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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